Bone graft materials derived from mineralized gelatin
The present invention provides novel methods of forming mineralized gelatin carriers from bone. The present invention further provides mineralized gelatin carriers themselves; bone products that include such mineralized gelatin carriers including DBM bone products; and kits that include mineralized gelatin carriers formed from bone. The present invention further provides methods for making DBM bone products, wherein both the DBM and a mineralized gelatin carrier for the DBM are derived independently from a bone lot.
1. A bone product comprising a mineralized carrier comprising bone gelatin solubilized and extracted from bone while retaining solubilized minerals from the bone, and the retained solubilized minerals from the bone;
wherein the bone product further comprises bone graft materials.
2. A bone product comprising a mineralized carrier produced by a method comprising
solubilizing and extracting gelatin solution from bone, while retaining solubilized minerals from said bone in said gelatin solution;
neutralizing the pH of the solubilized and extracted gelatin solution to form a neutralized mineralized carrier solution; and
processing the neutralized mineralized carrier solution into a mineralized carrier comprising bone gelatin and the solubilized minerals from bone,
wherein the bone product further comprises bone graft materials.
3. The bone product of claim 2 , wherein said mineralized carrier is a freeze dried mineralized carrier.
4. The bone product of claim 2 , wherein said mineralized carrier is a liquid mineralized carrier formed by reconstituting a freeze-dried mineralized carrier.
5. The bone product of claim 2 , wherein said mineralized carrier is a solid or semi-solid mineralized carrier formed by cooling a liquid mineralized carrier that was reconstituted from a freeze-dried mineralized carrier.