Personal care compositions comprising a methyl naphthalenyl ketone or a derivative thereof
View Patent ↗A personal care composition comprising a methyl naphthalenyl ketone or a derivative thereof, such as 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2naphthalenyl)-ethan-1-one, for down regulating at least one TRP receptor associated with a pain response, including but not limited to TRPV1 and TRPA1 receptors to reduce skin irritation associated with hair removal.
1. A method of reducing skin irritation during a hair removal process, the method comprising:
a) applying a personal care composition comprising from about 0.001% to about 1% of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-ethan-1-one molecule or isomers thereof to a portion of skin subject to hair removal to down regulate at least one transient receptor potential (TRP) channel selected from the group consisting of a TRPV1 receptor, a TRPA1 receptor, and a combination thereof; and
b) at least partially removing the hair from the portion of skin.
2. The method of claim 1 , wherein said step of applying said personal care composition forms a minimum dosage level of at least 0.0015 mg/cm 2 of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-ethan-1-one molecule or isomers thereof.
3. The method of claim 1 , further comprising a step of leaving said personal care composition on said portion of treated skin for about 5 seconds to 120 seconds.
4. The method of claim 1 , further comprising the step of removing said personal care composition from said portion of treated skin, followed by applying a second personal care composition comprising a level of a methyl naphthalenyl ketone which is greater than the level of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)-ethan-1-one molecule or isomers thereof in said personal care composition applied in step 1a.
5. The method of claim 1 , wherein said portion of skin is selected from the group consisting of lips, face, neck, underarm, upper and/or forearm, chest, back, loin, leg, thigh, abdomen and mixtures thereof.
6. The method of claim 1 , wherein both the TRPV1 receptor and the TRPA1 receptors are down regulated.
7. The method of claim 1 , wherein said at least one TRP receptor is blocked by about 50% as determined by the Pre-Incubation Test Method as defined herein.
8. The method of claim 1 , wherein the personal care composition is selected from the group consisting of cosmetics, moisturizers, lotions, oils, personal cleansers, facial cleansers, shave gels, shave foams, shave oils, pre-shave lotions or oils, and combinations thereof.
9. The method of claim 1 , wherein the personal care composition further comprises an additional sensate selected from the group consisting of: p-methane-3,8-diol; Isopulegol; Menthoxypropane-1,2-diol; Curcumin; Menthyl Lactate; Gingerol; Icilin; Menthol; Tea Tree Oil; Methyl Salicylate; Camphor; Peppermint Oil; N-Ethyl-p-menthane-3-carboxamide; Ethyl 3-(p-menthane-3-carboxamido)acetate; 2-Isopropyl-N,2,3-trimethylbutyramide; Menthone glycerol ketal, and mixtures thereof.