IP Library › Granted Patent US 8,575,161

Granted Patent B2

US 8,575,161 · App. 12/988,147 · Granted Nov 5, 2013

Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators

Inventors: Didier Roche (Ecully, FR); Gisèle Mautino (Chenneviére sur Marne, FR); Ingo Kober (Gross-Gerau, DE); Francis Contard (Lyons, FR); Serge Christmann-Franck (Antony, FR); Saumitra Sengupta (Kolkata, IN); Ramesh Sistla (Bangalore, IN); Gummadi Venkateshwar Rao (Bangalore, IN)

Assignee: Merck Patent GmbH

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 8,575,161
App. No.: 12/988,147
Granted: Nov 5, 2013
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention relates to compounds of formula (I) wherein the substituents are as defined in the claims, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention and/or amelioration of one or more symptoms of disease or disorders related to the activity of FXR. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).

Claims (577)

1. A compound, which is

4-(4-Bromo-2-ethoxycarbonyl-benzofuran-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-(4-Bromo-2-carboxy-benzofuran-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

5-[4-(3-Methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-[4-(4-Methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-[4-(3-Trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-[4-(3-Chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-[4-(3-Fluoro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-[4-(3-Chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-(4-Benzenesulfonyl-piperazin-1-yl)-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-fluoro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-fluoro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(pyrrolidine-1-carbonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

2-[4-(4-Bromo-2-carboxy-benzofuran-5-yl)-piperazine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

4-(4-Chloro-2-ethoxycarbonyl-benzofuran-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-(2-Carboxy-4-chloro-benzofuran-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-Bromo-5-[4-(3-trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3-Methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(pyrrolidine-2-carbonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(Adamantane-1-carbonyl)-piperazin-1-yl]-4-bromo-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-chloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-(4-Benzoyl-piperazin-1-yl)-4-bromo-benzofuran-2-carboxylic acid

5-[4-(3,5-Difluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(4-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(4-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(4-chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

5-[4-(3-Trifluoromethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(3-trifluoromethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(3-cyano-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-(4-tert-butylcarbamoyl-piperazin-1-yl)-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-fluoro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(3,5-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(3,5-difluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzofuran-2-carboxylic acid

4-Bromo-5-(4-pyridin-4-ylmethyl-piperazin-1-yl)-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-trifluoromethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-phenoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3,5-dimethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3-Allyl-2-hydroxy-benzyl)-piperazin-1-yl]-4-bromo-benzofuran-2-carboxylic acid

5-(4-Benzenesulfonyl-piperazin-1-yl)-4-bromo-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(4-chloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(4-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-trifluoromethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3-Carboxy-benzyl)-piperazin-1-yl]-4-chloro-benzofuran-2-carboxylic acid

4-Chloro-5-(4-pyridin-3-ylmethyl-piperazin-1-yl)-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(4-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-methoxy-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-fluoro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3,5-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-fluoro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-cyano-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid amide

4-Bromo-5-[4-(3-fluoro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid ethoxy-amide

4-Bromo-5-[4-(3-trifluoromethyl-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-trifluoromethoxy-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-methoxy-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3,5-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-methyl-1H-benzoimidazole-4-carbonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-chloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-methoxy-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-trifluoromethyl-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-trifluoromethoxy-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-methyl-1H-benzoimidazole-4-carbonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(1H-Benzoimidazole-5-carbonyl)-piperazin-1-yl]-4-chloro-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2,5-dichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3,5-dimethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-chloro-phenylmethanesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2-Chloro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(3-Fluoro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-(2-Carboxy-4-methyl-benzofuran-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

{4-Bromo-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1yl]-benzofuran-2-yl}morpholin-4-yl-methanone

4-Bromo-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid (2-methoxy-ethyl)-amide

4-Bromo-5-[4-(2,5-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,5-dichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(1H-Benzoimidazole-5-carbonyl)-piperazin-1-yl]-4-bromo-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,6-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2,6-Dichloro-benzoyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2,5-Dichloro-benzoyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(3,5-Dichloro-benzoyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Methyl-5-[4-(3-trifluoromethoxy-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2-Chloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(3-Chloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2,5-Dichloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(3-Fluoro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Methyl-5-[4-(3-trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Methyl-5-[4-(3-trifluoromethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3-Chloro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2,5-Dichloro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(3-Chloro-phenylmethanesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-chloro-6-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-chloro-6-fluoro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-chloro-phenylmethanesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-fluoro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2-Fluoro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,6-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2,6-Dichloro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2,6-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,3-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2,3-Dichloro-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2,3-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2,5-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,3-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Methyl-5-[4-(3-trifluoromethyl-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Methyl-5-[4-(2-methyl-1H-benzoimidazole-4-carbonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2-Fluoro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2-Chloro-6-fluoro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2,6-Dichloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3,5-dichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3,5-Dichloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3,5-dichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3-Allyl-2-hydroxy-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2,3-Dimethoxy-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(5-chloro-thiophen-2-ylmethyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-(2-Carboxy-4-cyano-benzofuran-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-Bromo-5-[4-(3-ethoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid benzylamide

5-[4-(3,5-Dichloro-2-hydroxy-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

5-(4-Benzo[1,3]dioxol-4-ylmethyl-piperazin-1-yl)-4-bromo-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,6-dichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2,4-dichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2-Allyloxy-benzyl)-piperazin-1-yl]-4-bromo-benzofuran-2-carboxylic acid

5-{4-[3-(2,6-Dichloro-phenyl)-5-isopropyl-isoxazole-4-carbonyl]-piperazin-1-yl}-4-methyl-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(3-Allyloxy-benzyl)-piperazin-1-yl]-4-bromo-benzofuran-2-carboxylic acid

5-[4-(3-Allyl-2-methoxy-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-tert-butyl-2-hydroxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Methyl-5-(4-naphthalen-1-ylmethyl-piperazin-1-yl)-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-hydroxy-naphthalen-1-ylmethyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(2-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Bromo-5-[4-(3-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

{5-[4-(3,5-Dichloro-2-hydroxy-benzenesulfonyl)-piperazin-1-yl]-4-methyl-benzofuran-2-yl}-morpholin-4-yl-methanone

{4-Bromo-5-[4-(2-fluoro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-yl}-morpholin-4-yl-methanone

{4-Bromo-5-[4-(2-chloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-yl}-piperidin-1-yl-methanone

{4-Bromo-5-[4-(2,6-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-yl}-piperidin-1-yl-methanone

{4-Bromo-5-[4-(2,6-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-yl}-morpholin-4-yl-methanone

5-[4-(3,5-Dichloro-2-hydroxy-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Methyl-5-[4-(2,3,6-trichloro-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-[4-(2,3-Dichloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2,6-dichloro-benzoyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

{4-Chloro-5-[4-(2,3-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-yl}-morpholin-4-yl-methanone

{4-Bromo-5-[4-(2,6-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-yl}-(4-methyl-piperazin-1-yl)-methanone

4-Bromo-5-[4-(2,6-dichloro-benzenesulfonyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid (2-dimethylamino-ethyl)-amide

4-Chloro-5-[4-(2-hydroxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

{5-[4-(2,6-Dichloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-yl}-morpholin-4-yl-methanone

4-Chloro-5-[4-(2-chloro-6-hydroxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-chloro-6-methoxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(3-ethoxy-2-hydroxy-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

4-Chloro-5-[4-(2-chloro-3-trifluoromethyl-benzyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

5-{4-[3-(2,6-Dichloro-phenyl)-5-isopropyl-isoxazol-4-ylmethyl]-piperazin-1-yl}-4-methyl-benzofuran-2-carboxylic acid

5-[4-(2,6-Dichloro-benzyl)-piperazin-1-yl]-4-methyl-benzofuran-2-carboxylic acid amide

4-[2-(1H-tetrazol-5-yl)-benzofuran-5-yl]-piperazine-1-carboxylic acid terbutyl ester

5-(4-Benzhydryl-piperazin-1-yl)-4-methyl-benzofuran-2-carboxylic acid or

4-Chloro-5-[4-(2-methyl-5-thiophen-2-yl-2H-pyrazol-3-ylmethyl)-piperazin-1-yl]-benzofuran-2-carboxylic acid

or a stereoisomeric form thereof, or a mixture of stereoisomeric forms thereof or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition, comprising a compound according to claim 1 and one or more pharmaceutically acceptable excipients.

3. A pharmaceutically acceptable salt of a compound of claim 1 .

4. A compound of claim 1 , which is