IP Library Granted Patent US 8,133,395
Granted Patent B2
US 8,133,395 · App. 12/994,166 · Granted Mar 13, 2012

Automated column packing method

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Quick Facts
Patent No.
US 8,133,395
App. No.
12/994,166
Granted
Mar 13, 2012
Kind
B2
Abstract

A method for automatically without any required manual interaction packing a media bed in a column ( 3 ) from a slurry being a dispersion of said media particles and a liquid, said method comprising the steps a)-f) which all are performed automatically: a) filling the column ( 3 ) with a certain volume of slurry; b) packing a media bed from the slurry to a predefined target bed height or a predefined target bed compression; c) testing the separation efficiency of the packed bed; d) automatically unpacking the bed if test results not are acceptable or alternatively flow conditioning the packed bed if test results not are acceptable and return to c); e) calculating new volume of slurry to be filled into the column based on the test results; f) repeat from a).

Claims (12)

1. A method for automatically without any required manual interaction packing a media bed in a column ( 3 ) from a slurry being a dispersion of said media particles and a liquid, said method comprising the steps a)-f) which all are performed automatically:

a) filling the column ( 3 ) with a certain volume of slurry;

b) packing a media bed from the slurry to a predefined target bed height or a predefined target bed compression;

c) testing the separation efficiency of the packed bed;

d) automatically unpacking the bed if test results not are acceptable or alternatively flow conditioning the packed bed if test results not are acceptable and return to c);

e) calculating new volume of slurry to be filled into the column based on the test results; and

f) repeat from a).

2. The method of claim 1 , further comprising the step of automatically priming and/or sanitizing the column before filling the column with slurry.

3. The method of claim 1 , further comprising the step of automatically calculating the volume of slurry to be filled into the column given data entered by the user and/or data measured inline.

4. The method of claim 1 , further comprising the step of automatically rinsing the hoses after filling the column with slurry and before packing is started.

5. The method of claim 1 , wherein the testing can be a pulse test, a transitional test, a pressure/flow test, a stability test and/or a void measurement.

6. The method of claim 1 , further comprising the step of automatic sanitization of the packed column and/or providing the packed column in a storage solution if test results in step d) are acceptable.

Assignments (2)
CHANGE OF NAME Recorded Oct 5, 2020
From: GE HEALTHCARE BIO-SCIENCES AB
To: CYTIVA SWEDEN AB
Reel/Frame 054262/0184 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 23, 2010
From: KARLSSON, JOHAN F.; LUNDKVIST, JOAKIM
To: GE HEALTHCARE BIO-SCIENCES AB
Reel/Frame 025394/0981 →