4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases

1. A compound of formula (I)

wherein

R 1 is phenyl substituted by one or two substituents independently selected from C 1-6 alkyl, —OR 5 , halo, —CN, —COR 6 , CO 2 R 7 , —CONR 8 R 9 , —NR 10 R 11 , —NHCOR 12 , —SO 2 R 13 , —(CH 2 ) m SO 2 NR 14 R 15 , —NHSO 2 R 16 , and 5-membered heteroaryl wherein the 5-membered heteroaryl contains one or two heteroatoms independently selected from oxygen and nitrogen; or pyridinyl optionally substituted by one or two substituents independently selected from C 1-6 alkyl, —OR 17 , halo, —SO 2 R 18 , —SO 2 NR 19 R 20 , —NHSO 2 R 21 and —NHCOR 24 ;

R 2 is —(CH 2 ) n -phenyl optionally substituted by —CN or —NR 22 R 23 ; 5- or 6-membered heteroaryl wherein the 5- or 6-membered heteroaryl contains one or two heteroatoms independently selected from oxygen, nitrogen and sulphur and is optionally substituted by C 1-6 alkyl, halo or —(CH 2 ) q NR 25 R 26 ; or C 3-6 cycloalkyl optionally substituted by phenyl;

R 3 is hydrogen or fluoro;

R 4 is hydrogen or methyl;

R 7 , R 17 , R 19 , R 20 , R 22 , R 23 , R 27 , R 28 and R 29 are each independently hydrogen or C 1-6 alkyl;

R 5 is hydrogen, C 1-6 alkyl or —CF 3 ; R 6 , R 12 , R 13 , R 18 , R 33 and R 34 are each independently C 1-6 alkyl;

R 8 and R 9 are each independently hydrogen or C 1-6 alkyl, or R 8 and R 9 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom;

R 10 and R 11 are each independently hydrogen or C 1-6 alkyl, or R 10 and R 11 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom;

R 14 and R 15 are each independently hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl or —(CH 2 ) p phenyl, or R 14 and R 15 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl optionally containing an oxygen atom;

R 16 is C 1-6 alkyl; or phenyl optionally substituted by C 1-6 alkyl;

R 21 is C 3-6 cycloalkyl; C 1-6 alkyl optionally substituted by —CF 3 ; phenyl optionally substituted by one or two substituents independently selected from C 1-6 alkyl, —OR 27 , —CO 2 R 28 and halo; —(CH 2 ) u NR 35 R 36 ; or 5-membered heteroaryl wherein the 5-membered heteroaryl contains one or two heteroatoms independently selected from oxygen, nitrogen and sulphur and is optionally substituted by one or two substituents independently selected from C 1-6 alkyl;

R 24 is C 1-6 alkyl optionally substituted by —OR 29 ;

R 25 and R 26 , together with the nitrogen atom to which they are attached, are linked to form a 5-, 6- or 7-membered heterocyclyl or a 10-membered bicyclic heterocyclyl wherein the 5-, 6- or 7-membered heterocyclyl or the 10-membered bicyclic heterocyclyl optionally contains an oxygen atom, a sulphur atom or a further nitrogen atom and is optionally substituted by one or two substituents independently selected from C 1-6 alkyl, C 3-6 cycloalkyl, halo, oxo, phenyl optionally substituted by halo, pyridinyl, —(CH 2 ) r OR 30 , —(CH 2 ) s NR 31 R 32 , —COR 33 and —SO 2 R 34 ;

R 30 is hydrogen, C 1-6 alkyl or —(CH 2 ) t phenyl;

R 31 and R 32 , together with the nitrogen atom to which they are attached, are linked to form a 6-membered heterocyclyl optionally containing an oxygen atom;

R 35 and R 36 , together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 5- or 6-membered heterocyclyl optionally contains an oxygen atom or a further nitrogen atom and is optionally substituted by one or two substituents independently selected from C 1-6 alkyl;

m, n, p, q, r, s and t are each independently 0, 1 or 2; and

u is 1 or 2;

or a salt thereof.

2. A compound of formula (I) according to claim 1 or a salt thereof wherein R 1 is pyridinyl optionally substituted by one or two substituents independently selected from C 1-6 alkyl, —OR 17 , halo and —NHSO 2 R 21 .

3. A compound of formula (I) according to claim 1 or a salt thereof wherein R 1 is pyridinyl substituted by —OR 17 and —NHSO 2 R 21 .

4. A compound of formula (I) according to claim 1 or a salt thereof wherein R 2 is 5- or 6-membered heteroaryl wherein the 5- or 6-membered heteroaryl contains one or two heteroatoms independently selected from oxygen, nitrogen and sulphur and is optionally substituted by C 1-6 alkyl or —(CH 2 ) q NR 25 R 26 .

5. A compound of formula (I) according to claim 1 or a salt thereof wherein R 2 is 5- or 6-membered heteroaryl wherein the 5- or 6-membered heteroaryl contains one or two heteroatoms independently selected from oxygen, nitrogen and sulphur and is substituted by —(CH 2 ) q NR 25 R 26 .

6. A compound of formula (I) according to claim 1 or a salt thereof wherein R 3 is hydrogen.

7. A compound of formula (I) according to claim 1 or a salt thereof wherein R 4 is hydrogen.

8. A compound of formula (I) according to claim 1 which is:

6-bromo-N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]-2-pyridinecarboxamide;

N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]cyclohexanecarboxamide;

N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]-2-pyridinecarboxamide;

N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]-3-phenylpropanamide;

4-cyano-N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]benzamide;

3-(dimethylamino)-N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]benzamide;

(1R,2R)—N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]-2-phenylcyclopropanecarboxamide;

N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]-2-furancarboxamide;

N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]cyclopropanecarboxamide;

N-{6-[5-(aminosulfonyl)-3-pyridinyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{3-[(aminosulfonyl)methyl]phenyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-{6-[5-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

3-(4-{[(2-methyl-1,3-thiazol-4-yl)carbonyl]amino}-1H-indazol-6-yl)benzoic acid;

N-(6-{6-chloro-5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-{6-[4-(acetylamino)phenyl]-1H-indazol-4-yl}-2-pyridinecarboxamide;

N-(6-{3-[(methylsulfonyl)amino]phenyl}-1H-indazol-4-yl)-2-pyridinecarboxamide;

N-[6-(3-{[(4-methylphenyl)sulfonyl]amino}phenyl)-1H-indazol-4-yl]-2-pyridinecarboxamide;

N-{6-[3,4-bis(methyloxy)phenyl]-1H-indazol-4-yl}-2-pyridinecarboxamide;

N-{6-[3-(4-morpholinyl)phenyl]-1H-indazol-4-yl}-2-pyridinecarboxamide;

N-(6-{3-[(methylamino)carbonyl]phenyl}-1H-indazol-4-yl)-2-pyridinecarboxamide;

N-{6-[3-(2-furanyl)phenyl]-1H-indazol-4-yl}-2-pyridinecarboxamide;

N-{6-[4-(2-furanyl)phenyl]-1H-indazol-4-yl}-2-pyridinecarboxamide;

N-[6-(3-{[(phenylmethyl)amino]sulfonyl}phenyl)-1H-indazol-4-yl]-2-pyridinecarboxamide;

N-[6-(3-cyanophenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-{6-[3-(methylsulfonyl)phenyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

N-[6-(3-chloro-2-fluorophenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{3-[(1-methylethyl)oxy]phenyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-{6-[3-(ethyloxy)-2-fluorophenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(3-fluorophenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{3-[(diethylamino)carbonyl]phenyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{3-[(dimethylamino)carbonyl]phenyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{3-[(methylamino)sulfonyl]phenyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-[6-(3-acetylphenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(2,3-difluorophenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-{6-[3-(4-morpholinylsulfonyl)phenyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{3-[(trifluoromethyl)oxy]phenyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

2-methyl-N-{6-[3-(1-pyrrolidinylcarbonyl)phenyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-methyl-N-{6-[3-(1-pyrrolidinylsulfonyl)phenyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

N-{6-[3-(acetylamino)phenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-{6-[3-(aminocarbonyl)phenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{3-[(cyclopropylamino)sulfonyl]phenyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-{6-[3-(dimethylamino)phenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(3-methylphenyl)-1H-indazol-4-yl]cyclopropanecarboxamide;

N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]cyclopropanecarboxamide;

N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]cyclohexanecarboxamide;

N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]-2-pyridinecarboxamide;

3-(dimethylamino)-N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]benzamide;

N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]-3-phenylpropanamide;

(1R,2R)—N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]-2-phenylcyclopropanecarboxamide;

N-[6-(4-hydroxyphenyl)-1H-indazol-4-yl]-2-furancarboxamide;

2-methyl-N-{6-[5-(methylsulfonyl)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-methyl-N-[6-(4-methyl-3-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide;

2-methyl-N-[6-(3-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide;

2-methyl-N-[6-(2-oxo-1,2-dihydro-4-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide;

2-methyl-N-[6-(4-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{6-methyl-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-(4-morpholinylmethyl)-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-(1-piperidinylmethyl)-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-{[3-methyl-4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-thiazole-4-carboxamide;

2-{[4-(1-methylethyl)-1-piperazinyl]methyl}-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide; N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-(4-morpholinylmethyl)-1,3-thiazole-4-carboxamide;

N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-(1-piperidinylmethyl)-1,3-thiazole-4-carboxamide;

2-{[3-methyl-4-(1-methylethyl)-1-piperazinyl]methyl}-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[5-[(ethylsulfonyl)amino]-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[6-(methyloxy)-5-({[3-(methyloxy)phenyl]sulfonyl}amino)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

N-{6-[5-[(cyclohexylsulfonyl)amino]-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[5-{[(1-methylethyl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[6-(methyloxy)-5-({[2-(methyloxy)phenyl]sulfonyl}amino)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[6-(methyloxy)-5-({[4-(methyloxy)phenyl]sulfonyl}amino)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-(6-{6-(methyloxy)-5-[(propylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

4-({[5-(4-{[(2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazol-4-yl)carbonyl]amino}-1H-indazol-6-yl)-2-(methyloxy)-3-pyridinyl]amino}sulfonyl)benzoic acid;

3-({[5-(4-{[(2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazol-4-yl)carbonyl]amino}-1H-indazol-6-yl)-2-(methyloxy)-3-pyridinyl]amino}sulfonyl)benzoic acid;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-[6-(6-(methyloxy)-5-{[(3,3,3-trifluoropropyl)sulfonyl]amino}-3-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-[6-(6-(methyloxy)-5-{[(2,2,2-trifluoroethyl)sulfonyl]amino}-3-pyridinyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-2-pyridinecarboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-(4-morpholinylmethyl)-2-pyridinecarboxamide; N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-(1-piperidinylmethyl)-2-pyridinecarboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-{[4-(1-methylethyl)-1-piperazinyl]methyl}-2-pyridinecarboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-{[3-methyl-4-(1-methylethyl)-1-piperazinyl]methyl}-2-pyridinecarboxamide;

6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-pyridinecarboxamide;

N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-(1-piperidinylmethyl)-2-pyridinecarboxamide;

N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-(4-morpholinylmethyl)-2-pyridinecarboxamide;

6-{[4-(1-methylethyl)-1-piperazinyl]methyl}-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-pyridinecarboxamide;

6-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-pyridinecarboxamide;

6-{[3-methyl-4-(1-methylethyl)-1-piperazinyl]methyl}-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-pyridinecarboxamide;

N-{6-[5-[(cyclopropylsulfonyl)amino]-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-{6-[5-{[(2,4-difluorophenyl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-{6-[5-[(2-hydroxypropanoyl)amino]-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-{[4-(1-methylethyl)-1-piperazinyl]methyl}-2-pyridinecarboxamide;

N-{6-[5-{[(2,4-difluorophenyl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide;

2-[(2-methyl-4-morpholinyl)methyl]-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-(tetrahydro-1,4-oxazepin-4(5H)-ylmethyl)-1,3-thiazole-4-carboxamide;

2-[(2-ethyl-4-morpholinyl)methyl]-N-(6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-(1-methyl-6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-{6-[5-{[(2,4-difluorophenyl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1-methyl-1H-indazol-4-yl}-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-(6-{6-(methyloxy)-5-[(1H-pyrazol-4-ylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-{6-[5-{[(1,2-dimethyl-1H-imidazol-5-yl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[5-{[(2-methyl-1H-imidazol-4-yl)sulfonyl]amino}-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-(6-{6-(methyloxy)-5-[(2-thienylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[5-[(1H-imidazol-4-ylsulfonyl)amino]-6-(methyloxy)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-N-{6-[6-(methyloxy)-5-({[2-(4-methyl-1-piperazinyl)ethyl]sulfonyl}amino)-3-pyridinyl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide;

N-[6-(6-chloro-5-{[(2-methylphenyl)sulfonyl]amino}-3-pyridinyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(6-chloro-5-{[(5-fluoro-2-methylphenyl)sulfonyl]amino}-3-pyridinyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(6-chloro-5-{[(2,5-dimethylphenyl)sulfonyl]amino}-3-pyridinyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-(ethyloxy)-5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-methyl-1H-indazol-4-yl)-6-methyl-2-pyridinecarboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-methyl-2-pyridinecarboxamide;

N-{6-[6-chloro-5-({[5-methyl-2-(methyloxy)phenyl]sulfonyl}amino)-3-pyridinyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(cyclopropylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(2,3-diaminophenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-{6-[4-(aminosulfonyl)phenyl]-1H-indazol-4-yl}-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-methyl-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{5-[(cyclopropylsulfonyl)amino]-6-hydroxy-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-[6-(5-hydroxy-3-pyridinyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide trifluoroacetate;

N-[6-(3-hydroxyphenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(4-chloro-3-hydroxyphenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(4-hydroxy-3-methylphenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-[6-(3-hydroxy-4-methylphenyl)-1H-indazol-4-yl]-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{4-chloro-3-[(methylsulfonyl)amino]phenyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

2-methyl-N-(6-{5-[(methylamino)sulfonyl]-3-pyridinyl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide;

N-(6-{5-[(diethylamino)sulfonyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide;

N-(6-{6-hydroxy-5-[(phenylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide; or

N-(6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-methyl-1H-indazol-4-yl)-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide; or

a salt thereof.

9. A compound of formula (I) according to claim 1 in the form of a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition comprising a compound of formula (I) as defined in claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

11. A method of treating a patient suffering from asthma or COPD comprising administering to said patient an effective amount of a compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, neat or admixed with a pharmaceutically acceptable excipient.