Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen
View Patent ↗This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of cancer by administering the herbal composition PHY906 in combination with one or more chemotherapeutic compounds to a mammal undergoing such chemotherapy.
1. A method of treating gastrointestinal stromal tumors or renal cell carcinoma in a mammal comprising administering a therapeutically effective amount of
i) an herbal preparation consisting essentially of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba , and Paeonia lactiflora ; and
ii) a chemotherapeutic formulation comprising sunitinib or the malate salt of sunitinib.
2. The method of claim 1 , wherein the herbal preparation and the chemotherapeutic formulation are administered at separate times.
3. The method of claim 1 , wherein the herbal preparation and chemotherapeutic formulation are administered via oral route.
4. The method of claim 1 , wherein the herbal preparation consists of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba, Paeonia lactiflora , and one or more pharmaceutically acceptable carriers.
5. The method of claim 1 , wherein the chemotherapeutic formulation comprises sunitinib or the malate salt of sunitinib.
6. The method of claim 1 , wherein the herbal preparation is administered before the administration of the chemotherapeutic formulation.
7. The method of claim 1 , wherein the herbal preparation is administered after the administration of the chemotherapeutic formulation.
8. The method of claim 1 , wherein the herbal preparation is administered concurrently with the administration of the chemotherapeutic formulation.
9. A method of relieving side effects of sunitinib or the malate salt of sunitinib in a mammal comprising administering a therapeutically effective amount of
i) an herbal preparation consisting essentially of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba , and Paeonia lactiflora ; and
ii) a chemotherapeutic formulation comprising sunitinib or the malate salt of sunitinib.
10. The method of claim 9 , wherein the herbal preparation and the chemotherapeutic formulation are administered at separate times.
11. The method of claim 9 , wherein the herbal preparation and chemotherapeutic formulation are administered via oral route.
12. The method of claim 9 , wherein the herbal preparation consists of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba, Paeonia lactiflora , and one or more pharmaceutically acceptable carriers.
13. The method of claim 9 , wherein the chemotherapeutic formulation comprises sunitinib or the malate salt of sunitinib.
14. The method of claim 9 , wherein the herbal preparation is administered before the administration of the chemotherapeutic formulation.
15. The method of claim 9 , wherein the herbal preparation is administered after the administration of the chemotherapeutic formulation.
16. The method of claim 9 , wherein the herbal preparation is administered concurrently with the administration of the chemotherapeutic formulation.
17. A method of enhancing anticancer activity of sunitinib or the malate salt of sunitinib in a mammal comprising administering a therapeutically effective amount of
i) an herbal preparation consisting essentially of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba , and Paeonia lactiflora ; and
ii) a chemotherapeutic formulation comprising sunitinib or the malate salt of sunitinib.
18. The method of claim 17 , wherein the herbal preparation and the chemotherapeutic formulation are administered at separate times.
19. The method of claim 17 , wherein the herbal preparation and chemotherapeutic formulation are administered via oral route.
20. The method of claim 17 , wherein the herbal preparation consists of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba, Paeonia lactiflora , and one or more pharmaceutically acceptable carriers.
21. The method of claim 17 , wherein the chemotherapeutic formulation comprises sunitinib or the malate salt of sunitinib.
22. The method of claim 17 , wherein the herbal preparation is administered before the administration of the chemotherapeutic formulation.
23. The method of claim 17 , wherein the herbal preparation is administered after the administration of the chemotherapeutic formulation.
24. The method of claim 17 , wherein the herbal preparation is administered concurrently with the administration of the chemotherapeutic formulation.