CYANOACRYLATE TISSUE ADHESIVES WITH DESIRABLE PERMEABILITY AND TENSILE STRENGTH
A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m 2 /day.
1 . A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m 2 /day.
2 . The sterilized cyanoacrylate adhesive composition of claim 1 , wherein said cure speed enhancer is a crown ether.
3 . The sterilized cyanoacrylate adhesive composition of claim 2 , wherein said crown ether is 18-crown-6.
4 . The sterilized cyanoacrylate adhesive composition of claim 3 , wherein said 18-crown-6 is present in the amount of 2 to 3200 ppm.
5 . The sterilized cyanoacrylate adhesive composition of claim 3 , wherein said 18-crown-6 is present in the amount of 40 to 1600 ppm.
6 . The sterilized cyanoacrylate adhesive composition of claim 1 , wherein said cyanoacrylate composition includes 99% 2-octyl cyanoacrylate.
7 . The sterilized cyanoacrylate adhesive composition of claim 1 having a viscosity of 2.5 to 70 cp.
8 . The sterilized cyanoacrylate adhesive composition of claim 1 having a viscosity of 5 to 30 cp.
9 . The sterilized cyanoacrylate adhesive composition of claim 1 , further including a free radical stabilizer and an anionic vapor phase stabilizer.
10 . The sterilized cyanoacrylate adhesive composition of claim 9 , wherein said free radical stabilizer is butylated hydroxyl anisole and said anionic vapor phase stabilizer is sulfur dioxide.
11 . The sterilized cyanoacrylate adhesive composition of claim 9 , further including a particulate agent chosen from the group consisting of vinyl pyrrolidone polymers and co-polymers.
12 . The adhesive composition of claim 1 wherein the water vapor transmission rate is from about 1000 to about 2500 g/m 2 /day.
13 . The adhesive composition of claim 12 wherein the Water Vapor Transmission Rate is from about 1500 to about 2200 g/m 2 /day.
14 . The adhesive composition of claim 1 wherein the film has a T-peel loading value of from about 34 to about 48 lbs.
15 . The adhesive composition of claim 1 wherein the film has a lap-shear tensile strength of from about 12 to about 18 lbs/in 2 .
16 . The adhesive composition of claim 1 wherein the film has a tension loading strength of from about 12 to about 16 lbs/in 2 .
17 . The adhesive composition of claim 1 wherein the film has a wound closure strength of from about 2 to about 4 lbs.
18 . A method of sealing tissue, including the steps of:
applying the sterilized cyanoacrylate adhesive composition as a liquid to a patient's tissue to be sealed; and
curing the sterilized cyanoacrylate adhesive composition to seal the patient's tissue, wherein the composition when cured to form a film on the patient's tissue has water vapor transmission rate of from about 950 to about 3000 g/m 2 /day.
19 . The method of claim 18 wherein the water vapor transmission rate is from about 1000 to about 2500 g/m 2 /day.
20 . The method of claim 19 wherein the water vapor transmission rate is from about 1500 to about 2200 g/m 2 /day.
21 . The method of claim 18 wherein the composition further comprises a polymerization accelerator.
22 . The method of claim 21 wherein the accelerator is 18-crown-6 ether.
23 . The method of claim 22 wherein the composition further comprises a free radical polymerization inhibitor and an anionic polymerization inhibitor.
24 . The method of claim 23 wherein the free radical polymerization inhibitor is BHA and the anionic polymerization inhibitor is SO 2 .