PROCESS FOR PRODUCTION OF RADIOPHARMACEUTICALS

1 . A process of preparing a fluorine-18 labeled compound comprising the steps:

a. Trapping of [F-18]fluoride on material A,

b. Eluting the [F-18]fluoride from material A using a solution B,

c. Addition of precursor D,

d. Nucleophilic substitution,

whereas,

solution B consist of an organic solvent L or a mixture of organic solvents L and a base E,

and

solvent L is not an ionic liquid,

and

the process comprises no azeotropic drying or evaporation after elution of [F-18]fluoride from material M prior addition of precursor D.

2 . A process according to claim 1 , wherein a gas G and/or a solvent S is passed through material A after trapping of [F-18]fluoride and prior elution using B.

3 . A process according to claim 2 , wherein water is removed from material A by passing G and/or S through A.

4 . A process according to claims 2 - 3 , wherein G is selected from the group comprising air, nitrogen, helium, argon, carbon dioxide, and mixtures thereof

5 . A process according to claims 2 - 4 , wherein S is selected from the group comprising air, acetonitrile, DMF, DMSO, THF, alcohols, toluene, benzene, sulfolan, and mixtures thereof

6 . A process according to claim 1 - 5 , wherein material A is a anion exchange material or cartridge or column made of anion exchange material.

7 . A process according to claims 1 - 6 , wherein material A is a QMA or PS-30 cartridge.

8 . A process according to claims 1 - 7 , wherein L consists of mixture of acetonitrile, DMF, DMSO, sulfolane, THF, tert-butanol, amyl alcohol, DMAA or mixtures thereof.

9 . A process according to claims 1 - 8 , wherein B contains water.

10 . A process according to claims 1 - 8 , wherein solution B not contains water.

11 . A process according to claims 1 - 10 , wherein B contains a complexing agent or a phase transfer catalyst.

12 . A process according to claims 11 , wherein B contains kryptofix or a crown ether.

13 . A process according to claims 1 - 12 , wherein base E is selected from the group comprising a:

a. potassium salt,

b. caesium salt,

c. rubidium salt,

d. tetraalkylammonium salt,

e. tetraalkylphosphonium salt.

14 . A process according to claims 1 - 13 , wherein base E is selected from the group comprising:

a. potassium carbonate,

b. potassium bicarbonate,

c. potassium oxalate,

d. potassium sulfonates,

e. potassium tert-alkoxylates,

f. caesium carbonate,

g. caesium bicarbonate

h. tetrabutylammonium hydroxide,

i. tetrabutylammonium bicarbonate,

j. tetrabutylammonium mesylate.

15 . A process according to claims 1 - 14 , wherein solution B is passed through material C prior elution of [F-18]fluoride from material A, wherein material C is a material appropriate for removing water from organic solvents.

16 . A process according to claims 1 - 15 , wherein solution B is passed through material C after elution of [F-18]fluoride from material A, wherein material C is a material appropriate for removing water from organic solvents.

17 . A process according to claims 15 - 16 , wherein a drying cartridge or column consisting of material C is used.

18 . A process according to claims 15 - 17 , wherein material C is selected from the group comprising

a. inorganic salts,

b. inorganic oxides,

c. resins,

d. molecular sieves,

or mixtures thereof.

19 . A process according to claim 18 , wherein material C is selected from the group comprising

a. sodium sulfate,

b. magnesium sulfate,

c. potassium carbonate,

d. calcium chloride,

e. calcium sulfate,

f. barium oxide,

g. magnesium oxide,

h. calcium oxide,

i. phosphorous oxide,

j. potassium hydroxide,

k. caesium carbonate,

l. caesium hydroxide,

m. molecular sieves,

or mixtures thereof.

20 . A process of preparing a fluorine-18 labeled compound comprising the steps:

a. Mixing of aqueous [F-18]fluoride with solution B,

b. Passing the mixture of aqueous [F-18]fluoride and B through material C.

c. Addition of precursor D,

d. Nucleophilic substitution,

whereas,

solution B consist of an organic solvent L or a mixture of organic solvents L and a base E,

optionally B also contains a complexing agent or a phase transfer catalyst,

optionally B also contains water,

and

solvent L is not an ionic liquid,

and

C is a material appropriate for removing water from organic solvents,

and

the process comprises no azeotropic drying or evaporation prior addition of precursor D.

21 . A process according to claim 20 , wherein L consists of mixture of acetonitrile, DMF, DMSO, sulfolane, THF, tert-butanol, amyl alcohol, DMAA or mixtures thereof.

22 . A process according to claims 20 - 21 , wherein B contains water.

23 . A process according to claims 20 - 21 , wherein solution B not contains water.

24 . A process according to claims 20 - 23 , wherein B contains a complexing agent or a phase transfer catalyst.

25 . A process according to claims 24 , wherein B contains kryptofix or a crown ether.

26 . A process according to claims 20 - 25 , wherein base E is selected from the group comprising a:

a. potassium salt,

b. caesium salt,

c. rubidium salt,

d. tetraalkylammonium salt,

e. tetraalkylphosphonium salt.

27 . A process according to claims 20 - 26 , wherein base E is selected from the group comprising:

a. potassium carbonate,

b. potassium bicarbonate,

c. potassium oxalate,

d. potassium sulfonates,

e. potassium tert-alkoxylates,

f. caesium carbonate,

g. caesium bicarbonate

h. tetrabutylammonium hydroxide,

i. tetrabutylammonium bicarbonate,

j. tetrabutylammonium mesylate.

28 . A process according to claims 20 - 27 , wherein solution B is passed through material C prior elution of [F-18]fluoride from material A, wherein material C is a material appropriate for removing water from organic solvents.

29 . A process according to claims 20 - 28 , wherein solution B is passed through material C after elution of [F-18]fluoride from material A, wherein material C is a material appropriate for removing water from organic solvents.

30 . A process according to claims 28 - 29 , wherein a drying cartridge or column consisting of material C is used.

31 . A process according to claims 28 - 30 , wherein material C is selected from the group comprising

a. inorganic salts,

b. inorganic oxides,

c. resins,

d. molecular sieves,

or mixtures thereof.

32 . A process according to claim 31 , wherein material C is selected from the group comprising

a. sodium sulfate,

b. magnesium sulfate,

c. potassium carbonate,

d. calcium chloride,

e. calcium sulfate,

f. barium oxide,

g. magnesium oxide,

h. calcium oxide,

i. phosphorous oxide,

j. potassium hydroxide,

k. caesium carbonate,

l. caesium hydroxide,

m. molecular sieves,

or mixtures thereof.