System, Method and Apparatus for Purifying Biological Fluids Such as Blood and Constituents Thereof
Provided herein is an innovative hemoperfusion system and method including a thermal-fused broad-spectrum biocidal iodinated interactive polymer for the treatment of biological contaminants in body fluids. In one exemplary embodiment, the system and method utilizes a Triosyn® thermal fused broad-spectrum iodinated interactive polymer, included in a hemoperfusion column, for devitalizing high levels of cell-free microorganisms in whole blood and biological fluids in relation with the characterization of blood cells viability and function post-treatment
1 . A method for decontaminating blood, comprising:
a) providing a hemoperfusion unit containing a low-density chamber including an effective amount of demand disinfectant, said demand disinfectant being an iodinated resin;
b) separating a unit of blood infected with a quantity of bacteria or viral particles to provide a red blood cell concentrate and a plasma concentrate;
c) discarding the plasma concentrate;
d) diluting the red blood cell concentrate with an aqueous solution;
e) filtering said diluted red blood cell concentrate through said hemoperfusion unit at a selected flow rate,
wherein the amount of bacteria or viral particles is reduced by greater than 90%.)
2 . The method of claim 1 , wherein the amount of bacteria or viral particles is reduced by greater than 95%.)
3 . The method of claim 1 , wherein the amount of bacteria or viral particles is reduced by greater than 99%.)
4 . The method of claim 1 , wherein the bacteria or viral particles are selected from the group consisting of Staphylococcus aureus, E. coli and MS2.)
5 . The method of claim 1 further comprising gravity filtering red blood cell concentrate through a leukocyte filter to remove leukocytes prior to diluting the red blood cell concentrate.)
6 . The method of claim 1 further comprising gravity filtering red blood cell concentrate through a leukocyte filter to remove leukocytes after diluting the red blood cell concentrate.)
7 . The method of claim 1 , wherein the aqueous solution is a saline solution.)
8 . The method of claim 1 , wherein the said flow rate is 50 ml/mm.)
9 . The method of claim 1 , wherein the said flow rate is 20 ml/mm.)
10 . The method of claim 1 , wherein the a low-density chamber further contains hydrodynamic diffusers.