Long-wearing removable pressure sensitive adhesive
View Patent ↗A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.
1. A reservoir or matrix transdermal delivery device for the controlled transdermal delivery of a therapeutic agent, said delivery device comprising
a therapeutic agent-containing reservoir or matrix; said reservoir or matrix comprising a first and second face; an impermeable backing layer in contact with said first face;
a pressure sensitive adhesive formulation in contact with said second face, said adhesive formulation comprising a mixture of at least one cross-linkable acrylic adhesive component and at least one non-cross-linkable acrylic adhesive component; said at least one cross-linkable acrylic adhesive and said at least one non-cross-linkable adhesive provided in such relative amounts that said adhesive formulation can adhere to human skin for a period of about 7-10 days but can be removed without causing trauma to the skin; and
a release liner releasably attached to said adhesive formulation.
2. The transdermal delivery device of claim 1 , wherein each of said cross-linkable adhesive and said non-cross-linkable adhesive is an acrylic adhesive.
3. The transdermal delivery device of claim 1 , wherein said therapeutic agent comprises a cardiovascular agent, androgenic steroid, estrogen, progestational agent, drug which acts on the central nervous system, nutritional agent, anti-inflammatory agent, antihistamine, miotic, dermatological agent, anti-spasmodic, anti-depressant, anti-cancer drug, anti-diabetic drug, anti-estrogen, hormonal agent, anti-infective agent, anti-allergenic agent, anti-pyretic agent, anti-migraine agent, tranquilizer, anti-psychotic agent, anti-emetic or anti-smoking agent.
4. The transdermal delivery device of claim 1 , wherein the cross-linkable acrylic adhesive is a self-cross-linkable acrylic adhesive component and the non-cross-linkable acrylic adhesive is a non-self-cross-linkable acrylic adhesive component.
5. A method of securing a transdermal drug delivery device to skin for a period of one to about 7 days which comprises contacting said skin with one face of said delivery device wherein at least part of said face is coated with a pressure sensitive adhesive formulation which comprises a mixture of at least one cross-linkable acrylic adhesive component and at least one non-cross-linkable acrylic adhesive component; said at least one cross-linkable acrylic adhesive and said at least one non-cross-linkable acrylic adhesive provided in such relative amounts that said adhesive formulation can adhere to skin for a period of about 7-10 days but can be removed without causing trauma to the skin.
6. The method of claim 5 , wherein the cross-linkable acrylic adhesive is a self-cross-linkable acrylic adhesive component and the non-cross-linkable acrylic adhesive is a non-self-cross-linkable acrylic adhesive component.
7. A method of securing a wound dressing, prosthesis, colostomy bag, electrode or diagnostic device to skin for a period of one to about 7-10 days which comprises contacting said skin with a portion of said dressing, prosthesis, colostomy bag, electrode or diagnostic device which has been coated with a pressure sensitive adhesive formulation which comprises a mixture of at least one cross-linkable acrylic adhesive component and at least one non-cross-linkable acrylic adhesive component; said at least one cross-linkable acrylic adhesive and said at least one non-cross-linkable acrylic adhesive provided in such relative amounts that said adhesive formulation can adhere to skin for a period of about 7-10 days but can be removed without causing trauma to the skin.
8. The method of claim 7 , wherein the cross-linkable acrylic adhesive is a self-cross-linkable acrylic adhesive component and the non-cross-linkable acrylic adhesive is a non-self-cross-linkable acrylic adhesive component.