Tricyclic heterocyclic compounds, compositions and methods of use thereof

1. A compound of formula I:

stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, wherein

X is N or CR 4 ;

Y is N or CR 5 ;

R 1 is 6-membered heterocyclyl, wherein R 1 is independently optionally substituted by halogen, oxo, —CN, —OR a , —SR a , —NR a R b , C 1-3 alkylene or C 1-6 alkyl optionally substituted by oxo, —CN or halogen;

R 2 is absent, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —(C 1-6 alkylene)-, —(C 2-6 alkenylene)-, —(C 2-6 alkynylene)-, —(C 0-6 alkylene)CN, —(C 0-3 alkylene)NR a (C 0-3 alkylene)-, —(C 0-3 alkylene)O(C 0-3 alkylene)-, —(C 0-3 alkylene)C(O)(C 0-3 alkylene)-, —(C 0-3 alkylene)NR a C(O)(C 0-3 alkylene)-, —(C 0-3 alkylene)C(O)NR a (C 0-3 alkylene)-, —(C 0-3 alkylene)C(O)O(C 0-3 alkylene)-, —(C 0-3 alkylene)OC(O)(C 0-3 alkylene)-, —(C 0-3 alkylene)NR a C(O)NR b (C 0-3 alkylene)-, —(C 0-3 alkylene)OC(O)NR a (C 0-3 alkylene)-, —(C 0-3 alkylene)NR a C(O)O(C 0-3 alkylene)-, —(C 0-3 alkylene)S(O) 1-2 (C 0-3 alkylene)-, —(C 0-3 alkylene)NR a S(O) 1-2 (C 0-3 alkylene)-, —(C 0-3 alkylene)S(O) 1-2 NR a (C 0-3 alkylene)- or —(C 0-3 alkylene)NR a S(O) 1-2 NR b (C 0-3 alkylene)-, wherein said alkyl, alkyenyl, alkynyl, alkylene, alkenylene and alkynylene are independently optionally substituted by halogen, oxo, —CN, —OR c , —SR c , —NR c R d or C 1-3 alkyl optionally substituted by halogen;

R 3 is absent, hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 6-14 aryl or 3-20 membered heterocyclyl, wherein R 3 is independently optionally substituted by R 6 ;

R 4 is hydrogen, halogen or C 1-3 alkyl;

R 5 is hydrogen, halogen, C 1-12 alkyl, C 2-12 alkenyl, C 2-12 alkynyl, —(C 0-3 alkylene)CN, —(C 0-3 alkylene)NR a R b , —(C 0-3 alkylene)OR a , —(C 0-3 alkylene)SR a , —(C 0-3 alkylene)C(O)R a , —(C 0-3 alkylene)NR a C(O)R b , —(C 0-3 alkylene)C(O)NR a R b , —(C 0-3 alkylene)C(O)OR a , —(C 0-3 alkylene)OC(O)R a , —(C 0-3 alkylene)NR a C(O)NR a R b , —(C 0-3 alkylene)OC(O)NR a R b , —(C 0-3 alkylene)NR a C(O)OR b , —(C 0-3 alkylene)S(O) 1-2 R a , —(C 0-3 alkylene)NR a S(O) 1-2 R b , —(C 0-3 alkylene)S(O) 1-2 NR a R b , —(C 0-3 alkylene)NR a S(O) 1-2 NR a R b , —(C 0-3 alkyl ene)C 3-12 cycloalkyl, —(C 0-3 alkylene)C 6-14 aryl, —(C 0-3 alkylene)3-12 membered heterocyclyl or —(C 0-3 alkylene)C(O)3-12 membered heterocyclyl, wherein said alkyl, alkenyl, alkynyl, alkylene, cycloalkyl, aryl and heterocyclyl are independently optionally substituted by halogen, oxo, —(C 0-3 alkylene)CN, —(C 0-3 alkylene)OR c , —(C 0-3 alkylene)NR c R d , —(C 0-3 alkylene)C(O)R c , —(C 0-3 alkylene)C(O)OR c , —(C 0-3 alkylene)C(O)NR c R d , —(C 0-3 alkylene)NR c C(O)R d , —(C 0-3 alkylene)OC(O)NR c R d , —(C 0-3 alkylene)NR c C(O)NR c R d , —(C 0-3 alkylene)NR c C(O)OR d , —(C 0-3 alkylene)S(O) 0-2 R c , —(C 0-3 alkylene)NR c S(O) 1-2 R d , —(C 0-3 alkylene)S(O) 1-2 NR c R d , —(C 0-3 alkylene)NR c S(O) 1-2 NR c R d or C 1-6 alkyl optionally substituted by oxo, —CN or halogen, wherein R 5 is other than —OH;

R 6 is independently oxo, halogen, —CN, —C(O)R a , —C(O)OR a , —NR a C(O)R b , —C(O)NR a R b , —NR a C(O)NR a R b , —OC(O)NR a R b , —NR a C(O)OR b , —S(O) 1-2 R a , —NR a S(O) 2 R a , —S(O) 2 NR a R b , —OR a , —SR a , —NR a R b , C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, 3-7 membered heterocycyl or C 6-14 aryl, and wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl and aryl are independently optionally substituted by halogen, oxo, —CN, —OR c , —SR c , —NR c R d or C 1-6 alkyl optionally substituted by oxo or halogen;

each R a and R b are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —(C 0-3 alkylene)C 3-6 cycloalkyl, —(C 0-3 alkylene)3-12 membered heterocyclyl, —(C 0-3 alkylene)C(O)3-12 membered heterocyclyl or —(C 0-3 alkylene)C 6-14 aryl, wherein said alkyl, cycloalkyl, heterocyclyl and aryl are independently optionally substituted by halogen, oxo, —CN, —OR e , —NR e R f , —C(O)R g , —C(O)OR g , —C(O)NR g R h , —NR g C(O)R h , —OC(O)NR g R h , —NR g C(O)NR g R h , —NR g C(O)OR h , —S(O) 1-2 R g , —NR g S(O) 1-2 R h , —S(O) 1-2 NR g R h , —NR g S(O) 1-2 NR g R h , C 3-6 cycloalkyl, 3-6 membered heterocyclyl, phenyl or C 1-3 alkyl optionally substituted by oxo or halogen, or taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by oxo, halogen, —C(O)C 1-6 alkyl or C 1-6 alkyl optionally substituted by oxo, halogen, OR g or NR g NR h ;

each R c and R d are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —(C 0-3 alkylene)C 3-6 cycloalkyl, —(C 0-3 alkylene)3-12 membered heterocyclyl, —(C 0-3 alkylene)C(O)3-12 membered heterocyclyl or —(C 0-3 alkylene)C 6-14 aryl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl and aryl are independently optionally substituted by halogen, oxo, —CN, —OR g , —NR g R h , —C(O)R g , —C(O)OR g , —C(O)NR g R h , —NR g C(O)R h , —OC(O)NR g R h , —NR g C(O)NR g R h , —NR g C(O)OR h , —S(O) 1-2 R g , —NR g S(O) 1-2 R h , —S(O) 1-2 NR g R h , —NR g S(O) 1-2 NR g R h , C 3-6 cycloalkyl, 3-6 membered heterocyclyl, phenyl or C 1-6 alkyl optionally substituted by oxo or halogen, or taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by oxo, halogen, —C(O)C 1-6 alkyl or C 1-6 alkyl optionally substituted by oxo or halogen; and

each R e , R f , R g , R h are independently hydrogen or C 1-6 alkyl optionally substituted by halogen or oxo.

2. The compound of claim 1 , wherein X is CR 4 and Y is CR 5 .

3. The compound of claim 2 , wherein R 1 is selected from:

4. The compound of claim 1 , wherein R 1 is 6 membered heterocyclyl, wherein R 1 is independently optionally substituted by halogen, oxo, —CN, —OR a , —SR a , —NR a R b , C 1-3 alkylene or C 1-6 alkyl optionally substituted by oxo, —CN or halogen; and R 2 is absent, —NHS(O) 2 —, —N(CH 3 )S(O) 2 —, —NHS(O) 2 CH 2 —, —C(O)CH 2 S(O) 2 , —C(O)O—, —NHC(O)O—, —N(CH 3 )C(O)O—, —NHC(O)OCH 2 —, —NHC(O)OCH 2 CH 2 —, —C(O)NH—, —CH 2 C(O)NH—, —CH 2 C(O)N(CH 3 )—, —NHC(O)—, —NHC(O)CH 2 —, —CH 2 O—, —CH 2 C(CH 2 ) 2 O—, —(CH 2 ) 2 O—, —NH—, —NHCH 2 —, —NHCH 2 CH 2 —, —CH 2 CN, —CH 2 CH 2 CN, —CH(CH 3 )CN, —CH(CH 3 )CH 2 CN, methylene, ethylene, —C(CH 3 ) 2 —, —CH 2 CF 3 , —CH 2 CH 2 CF 3 , —CH 2 CH 2 F, —CH 2 C(CH 3 ) 2 OH, —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 ,

wherein the wavy line represents the point of attachment in formula I.

5. The compound of claim 1 , wherein R 2 is absent, —NHS(O) 2 —, —N(CH 3 )S(O) 2 —, —NHS(O) 2 CH 2 —, —C(O)CH 2 S(O) 2 , —C(O)O—, —NHC(O)O—, —N(CH 3 )C(O)O—, —NHC(O)OCH 2 —, —NHC(O)OCH 2 CH 2 —, —C(O)NH—, —CH 2 C(O)NH—, —CH 2 C(O)N(CH 3 )—, —NHC(O)—, —NHC(O)CH 2 —, —CH 2 O—, —CH 2 C(CH 2 ) 2 O—, —(CH 2 ) 2 O—, —NH—, —NHCH 2 —, —NHCH 2 CH 2 —, —CH 2 CN, —CH 2 CH 2 CN, —CH(CH 3 )CN, —CH(CH 3 )CH 2 CN, methylene, ethylene, —C(CH 3 ) 2 —, —CH 2 CF 3 , —CH 2 CH 2 CF 3 , —CH 2 CH 2 F, —CH 2 C(CH 3 ) 2 OH, —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 ,

wherein the wavy line represents the point of attachment in formula I.

6. The compound of claim 1 , wherein R 1 is 6 membered heterocyclyl, wherein R 1 is independently optionally substituted by halogen, oxo, —CN, —OR a , —SR a , —NR a R b , C 1-3 alkylene or C 1-6 alkyl optionally substituted by oxo, —CN or halogen; R 2 is absent, —NHS(O) 2 —, —N(CH 3 )S(O) 2 —, —NHS(O) 2 CH 2 —, —C(O)CH 2 S(O) 2 , —C(O)O—, —NHC(O)O—, —N(CH 3 )C(O)O—, —NHC(O)OCH 2 —, —NHC(O)OCH 2 CH 2 —, —C(O)NH—, —CH 2 C(O)NH—, —CH 2 C(O)N(CH 3 )—, —NHC(O)—, —NHC(O)CH 2 —, —CH 2 O—, —CH 2 C(CH 2 ) 2 O—, —(CH 2 ) 2 O—, —NH—, —NHCH 2 —, —NHCH 2 CH 2 —, —CH 2 CN, —CH 2 CH 2 CN, —CH(CH 3 )CN, —CH(CH 3 )CH 2 CN, methylene, ethylene, —C(CH 3 ) 2 —, —CH 2 CF 3 , —CH 2 CH 2 CF 3 , —CH 2 CH 2 F, —CH 2 C(CH 3 ) 2 OH, —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 ,

and R 3 is absent, hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 6-14 aryl or 3-12 membered heterocyclyl, wherein R 3 is optionally substituted by 1 to 3 R 6 .

7. The compound of claim 1 , wherein R 3 is absent, hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 6-14 aryl or 3-12 membered heterocyclyl, wherein R 3 is optionally substituted by 1to 3 R 6 .

8. The compound of claim 7 , wherein R 3 is absent, hydrogen, methyl, ethyl, n-butyl, sec-butyl, t-butyl, —CF 3 , —CH 2 CF 3 , —CH 2 CH 2 F, —CH 2 CH 2 CF 3 , —CH 2 OCH 3 , —CH 2 CH 2 OCH 3 , —CH(CH 2 CH 3 )CH 2 OCH 3 , —CH(CH 3 )CH 2 CH 2 OH, —CH 2 C(CH 3 ) 2 OH, —CH 2 C(CF 3 ) 2 OH, —CH 2 CH 2 OH, —C(CH 3 ) 2 OH, —CH 2 CN, —(CH 2 ) 2 CN, —(CH 2 ) 3 CN, —CH(CH 3 )CH 2 CN, —C(CH 3 ) 2 CN, —CH(CH 3 )CN, —CH 2 NH 2 , —CH(CH 3 )N(CH 3 ) 2 , —CH 2 CH 2 N(CH 3 ) 2 , cyclopropyl, 1-cyanocycloprop-1-yl, 1-trifluoromethylcycloprop-1-yl, 1-methylcycloprop-1-yl, 2-fluorocyclopyrop-1-yl, 2,2-dimethylcycloprop-1-yl, 2-cyanocyclopropyl, cyclobutyl, 4-carboxyclobutyl, 1-cyanocyclobut-1-yl, 4-aminocyclobutyl, cyclopentyl, 3-aminocyclohexyl, 4-aminocyclohexyl, 2-hydroxycyclohexyl, 3-hydroxycyclohexyl, 4-hydroxycyclohexyl, 2-hydroxycyclohexyl, 4-cyanocyclohexyl, phenyl, 2-chloro-4-cyanophenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, 3-methylsulfonylphenyl, 3-fluorophenyl, 4-methoxyphenyl, pyridinyl, pyridin-3-yl, 6-cyanopyridinyl, 6-trifluoromethylpyridinyl, 2-cyanopyridin-4-yl, 4-cyanopyridin-2-yl, 5-cyanopyridin-2-yl, 3-fluoropyridin-5-yl, thiazol-5-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl, oxazol-2-yl, oxazol-4-yl, 1-methylpyrazol-5-yl, 1-methylpyrazol-4-yl, 1-methylimidazol-2-yl

oxetan-3-yl, piperidin-3-yl, piperidin-4-yl, N-methylpiperidin-2-yl, N-methylmorpholin-2-yl, 1-methylpyrrolidin-2-yl, pyrrolidinyl, pyrrolidinonyl, piperidinonyl, 3,3-difluoropyrrolidin-2-yl, 1-isopropylpyrrolidin-2-yl, 2-methylpyrrolidin-2-yl, 1-methylcyanopyrrolidin-2-yl, 1-cyclobutylpyrrolidin-2-yl, morpholinyl, pyran-4-yl, N-methylpiperazinyl, thiazol-5-yl, isothiazol-5-yl, N-ethylpiperidin-2-yl, N-(2-methoxyethyl)piperidin-2-yl, N-methylazepan-2-yl,

wherein the wavy line represents the point of attachment in formula I.

9. The compound of claim 1 , wherein —R 1 -R 2 -R 3 taken together are:

wherein the wavy line represents the point of attachment in formula I.

10. The compound of claim 1 , wherein R 4 is hydrogen, methyl or F.

11. The compound of claim 1 , wherein R 1 is 6 membered heterocyclyl, wherein R 1 is independently optionally substituted by halogen, oxo, —CN, —OR a , —SR a , —NR a R b , C 1-3 alkylene or C 1-6 alkyl optionally substituted by oxo, —CN or halogen; R 2 is absent, —NHS(O) 2 —, —N(CH 3 )S(O) 2 —, —NHS(O) 2 CH 2 —, —C(O)CH 2 S(O) 2 , —C(O)O—, —NHC(O)O—, —N(CH 3 )C(O)O—, —NHC(O)OCH 2 —, —NHC(O)OCH 2 CH 2 —, —C(O)NH—, —CH 2 C(O)NH—, —CH 2 C(O)N(CH 3 )—, —NHC(O)—, —NHC(O)CH 2 —, —CH 2 O—, —CH 2 C(CH 2 ) 2 O—, —(CH 2 ) 2 O—, —NH—, —NHCH 2 —, —NHCH 2 CH 2 —, —CH 2 CN, —CH 2 CH 2 CN, —CH(CH 3 )CN, —CH(CH 3 )CH 2 CN, methylene, ethylene, —C(CH 3 ) 2 —, —CH 2 CF 3 , —CH 2 CH 2 CF 3 , —CH 2 CH 2 F, —CH 2 C(CH 3 ) 2 OH, —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 ,

R 3 is absent, hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 6-14 aryl or 3-12 membered heterocyclyl, wherein R 3 is optionally substituted by 1 to 3 R 6 ; and R 5 is hydrogen, halogen, C 1-12 alkyl, —(C 0-3 alkylene)CN, —(C 0-3 alkylene)OR a , —(C 0-3 alkylene)NR a R b , —(C 0-3 alkylene)C(O)NR a R b , —(C 0-3 alkylene)C 3-12 cycloalkyl, —(C 0-3 alkylene)C(O)NR a R b , —(C 0-3 alkylene)NR a C(O)R b , —(C 0-3 alkylene)NR a S(O) 1-2 R b , —(C 0-3 alkylene)NR a S(O) 1-2 NR a R b , —(C 0-3 alkylene)S(O) 1-2 NR a R b , —(C 0-3 alkylene)NR a C(O)OR b , —(C 0-3 alkylene)S(O) 1-2 R a , wherein R 5 is independently optionally substituted by halogen, oxo, —(C 0-3 alkylene)CN, —(C 0-3 alkylene)OR c , —(C 0-3 alkylene)NR c R d , —(C 0-3 alkylene)C(O)R c , —(C 0-3 alkylene)C(O)OR c , —(C 0-3 alkylene)C(O)NR c R d , —(C 0-3 alkylene)NR c C(O)R d , —(C 0-3 alkylene)OC(O)NR c R d , —(C 0-3 alkylene)NR c C(O)NR c R d , —(C 0-3 alkylene)NR c C(O)OR d , —(C 0-3 alkylene)S(O) 0-2 R c , —(C 0-3 alkylene)NR c S(O) 1-2 R d , —(C 0-3 alkylene)S(O) 1-2 NR c R d , —(C 0-3 alkylene)NR c S(O) 1-2 NR c R d or C 1-6 alkyl optionally substituted by oxo, —CN or halogen, wherein the wavy line represents the point of attachment in formula I.

12. The compound of claim 11 , wherein R 4 is hydrogen, methyl, chloro or bromo.

13. The compound of claim 1 , wherein R 5 is hydrogen, halogen, C 1-12 alkyl, —(C 0-3 alkylene)CN, —(C 0-3 alkylene)OR a , —(C 0-3 alkylene)NR a R b , —(C 0-3 alkylene)C(O)NR a R b , —(C 0-3 alkylene)C 3-12 cycloalkyl, —(C 0-3 alkylene)C(O)NR a R b , —(C 0-3 alkylene)NR a C(O)R b , —(C 0-3 alkylene)NR a S(O) 1-2 R b , —(C 0-3 alkylene)NR a S(O) 1-2 NR a R b , —(C 0-3 alkylene)S(O) 1-2 NR a R b , —(C 0-3 alkylene)NR a C(O)OR b , —(C 0-3 alkylene)S(O) 1-2 R a , wherein R 5 is independently optionally substituted by halogen, oxo, —(C 0-3 alkylene)CN, —(C 0-3 alkylene)OR c , —(C 0-3 alkylene)NR c R d , —(C 0-3 alkylene)C(O)R c , —(C 0-3 alkylene)C(O)OR c , —(C 0-3 alkylene)C(O)NR c R d , —(C 0-3 alkylene)NR c C(O)R d , —(C 0-3 alkylene)OC(O)NR c R d , —(C 0-3 alkylene)NR c C(O)NR c R d , —(C 0-3 alkylene)NR c C(O)OR d , —(C 0-3 alkylene)S(O) 0-2 R c , —(C 0-3 alkylene)NR c S(O) 1-2 R d , —(C 0-3 alkylene)S(O) 1-2 NR c R d , —(C 0-3 alkylene)NR c S(O) 1-2 NR c R d or C 1-6 alkyl optionally substituted by oxo, —CN or halogen, wherein R 5 is other than —OH.

14. The compound of claim 1 , wherein —R 1 -R 2 -R 3 taken together are:

and R 5 is hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclobutyl, cyano, 2-methylbutyl, N-(2-hydroxyethyl)amino, N-(2-methoxyethyl)amino, methylsulfonylaminomethyl, 2-(methylsulfonylamino)ethyl, cyclopropylmethyl, 2-[N-(2-propylsulfonyl)amino]ethyl, 2-[N-(cyclopropylsulfonyl)-amino]ethyl, 2-(cyclopropylcarbonylamino)ethyl, 2-(acetylamino)ethyl, 2-(methoxymethyl-carbonylamino)ethyl, cyclopentoxymethyl, cyclopropylmethoxymethyl, 2,2,2-trifluoroethoxymethyl, cyclohexyl, methylamino, 2-(N,N-dimethylaminocarbonyl)ethyl, 2-(N-acetyl-N-methylamino)ethyl, 2-(ethoxycarbonylamino)ethyl, 1-hydroxyethyl, N-acylaminomethyl, 2-amino-1,1-difluoroethyl, N,N-dimethylamino, hydroxymethyl, methoxy, N-methylamino, N,N-dimethylamino,N-(2,2,2-trifluoroethyl)aminomethyl, (2-carboxycyclopropyl)(hydroxy)methyl, 2-hydroxyethyl, aminocarbonylmethyl, methylaminocarbonylmethyl, ethylaminocarbonylmethyl, 1-hydroxypropyl, 1,2-dihydroxyethyl, N-(2-methylpropyl)aminocarbonylmethyl, cyclopentylaminocarbonylmethyl, 2-(methoxycarbonylamino)ethyl, 2,2,2-trifluoro-1-hydroxyethyl, tert-butylaminocarbonylmethyl, cyclobutylaminocarbonylmethyl, 2-hydroxyethoxy, isopropylaminocarbonylmethyl, N—(N′N′-diemthylaminocarbonylmethyl)aminocarbonylmethyl, 4,4-difluorocyclohexylamino carbonylmethyl, 2,2-difluoroethylaminocarbonylmethyl, N-(2-hydroxyethyl)-N-methylaminocarbonylmethyl, cyclopentylmethyl, N-cyclopentyl-N-methylaminocarbonylmethyl, 2-amino-1,1-difluoroethyl, 3-pyridyl, morpholinomethyl, morpholinocarbonylmethyl, 2-cyano-2-methylethyl, trifluoromethyl, 1-hydroxy-1-methylethyl, 1-(N-isopropylaminocarbonyl)ethyl, 2-hydroxy-2-methylpropyl, N-(methylsulfonyl)-N-methylaminomethyl, difluoromethyl, 2-(2-butylsulfonylamino)ethyl, 2-(4-fluorophenylcarbonylamino)ethyl, 2-(cyclobutylcarbonylamino)ethyl, 2-(2-methylbutanoylamino)ethyl, 2-(benzoylamino)ethyl, 2,2-difluorocyclopropyl, 3-cyanobenzyl, 2-methylpropoxymethyl, 2-cyclopropylethyl, 3-pyridylmethyl, methylsulfonylmethyl, ethoxycarbonylaminomethyl, 3-pyridylcarbonylaminomethyl, isopropylsulfonylaminomethyl, 2-pyridylcarbonylaminomethyl, cyclopropylsulfonylaminomethyl, cyclopentylsulfonylaminomethyl, 2-methylpropanoylaminomethyl, cyclopropylcarbonylaminomethyl, 2-fluorobenzoylaminomethyl, 3-fluorobenzoylaminomethyl, 1-methylpropylsulfonylaminomethyl, 2-methylpropylsulfonylaminomethyl, methoxyacetylaminomethyl, ethylsylfonylaminomethyl, 2-(3,3,3-trifluoropropylsulfonylamino)ethyl, 2-(2,2-difluorocyclopropylcarbonylamino)ethyl, fluoromethyl, 2-hydroxyethylamino, 2-methoxyethylamino, 1-aminoethyl, 2-(ethylsulfonylamino)ethyl, 2,2-dimethylpropoxymethyl, 1-methoxyethyl, tert-butylsulfonylaminomethyl, 2,2,2-trifluoroethylaminomethyl,

wherein the wavy line represents the point of attachment in formula I.

15. The compound of claim 14 , wherein R 5 is hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclobutyl, cyano, 2-methylbutyl, N-(2-hydroxyethyl)amino, N-(2-methoxyethyl)amino, methylsulfonylaminomethyl, 2-(methylsulfonylamino)ethyl, cyclopropylmethyl, 2-[N-(2-propylsulfonyl)amino]ethyl, 2-[N-(cyclopropylsulfonyl)amino]ethyl, 2-(cyclopropylcarbonylamino)ethyl, 2-(acetylamino)ethyl, 2-(methoxymethylcarbonylamino)ethyl, cyclopentoxymethyl, cyclopropylmethoxymethyl, 2,2,2-trifluoroethoxymethyl, cyclohexyl, methylamino, 2-(N,N-dimethylaminocarbonyl)ethyl, 2-(N-acetyl-N-methylamino)ethyl, 2-(ethoxycarbonylamino)ethyl, 1-hydroxyethyl, N-acylaminomethyl, 2-amino-1,1-difluoroethyl, N,N-dimethylamino, hydroxymethyl, methoxy, N-methylamino, N,N-dimethylamino,N-(2,2,2-trifluoroethyl)aminomethyl, (2-carboxycyclopropyl)(hydroxy)methyl, 2-hydroxyethyl, aminocarbonylmethyl, methylaminocarbonylmethyl, ethylaminocarbonylmethyl, 1-hydroxypropyl, 1,2-dihydroxyethyl, N-(2-methylpropyl)aminocarbonylmethyl, cyclopentylaminocarbonylmethyl, 2-(methoxycarbonylamino)ethyl, 2,2,2-trifluoro-1-hydroxyethyl, tert-butylaminocarbonylmethyl, cyclobutylaminocarbonylmethyl, 2-hydroxyethoxy, isopropylaminocarbonylmethyl, N—(N′N′-diemthylaminocarbonylmethyl)aminocarbonylmethyl, 4,4-difluorocyclohexylaminocarbonylmethyl, 2,2-difluoroethylaminocarbonylmethyl, N-(2-hydroxyethyl)-N-methylaminocarbonylmethyl, cyclopentylmethyl, N-cyclopentyl-N-methylaminocarbonylmethyl, 2-amino-1,1-difluoroethyl, 3-pyridyl, morpholinomethyl, morpholinocarbonylmethyl, 2-cyano-2-methylethyl, trifluoromethyl, 1-hydroxy-1-methylethyl, 1-(N-isopropylaminocarbonyl)ethyl, 2-hydroxy-2-methylpropyl, N-(methylsulfonyl)-N-methylaminomethyl, difluoromethyl, 2-(2-butylsulfonylamino)ethyl, 2-(4-fluorophenylcarbonylamino)ethyl, 2-(cyclobutylcarbonylamino)ethyl, 2-(2-methylbutanoylamino)ethyl, 2-(benzoylamino)ethyl, 2,2-difluorocyclopropyl, 3-cyanobenzyl, 2-methylpropoxymethyl, 2-cyclopropylethyl, 3-pyridylmethyl, methylsulfonylmethyl, ethoxycarbonylaminomethyl, 3-pyridylcarbonylaminomethyl, isopropylsulfonylaminomethyl, 2-pyridylcarbonylaminomethyl, cyclopropylsulfonylaminomethyl, cyclopentylsulfonylaminomethyl, 2-methylpropanoylaminomethyl, cyclopropylcarbonylaminomethyl, 2-fluorobenzoylaminomethyl, 3-fluorobenzoylaminomethyl, 1-methylpropylsulfonylaminomethyl, 2-methylpropylsulfonylaminomethyl, methoxyacetylaminomethyl, ethylsylfonylaminomethyl, 2-(3,3,3-trifluoropropylsulfonylamino)ethyl, 2-(2,2-difluorocyclopropylcarbonylamino)ethyl, fluoromethyl, 2-hydroxyethylamino, 2-methoxyethylamino, 1-aminoethyl, 2-(ethylsulfonylamino)ethyl, 2,2-dimethylpropoxymethyl, 1-methoxyethyl, tert-butylsulfonylaminomethyl, 2,2,2-trifluoroethylaminomethyl,

wherein the wavy line represents the point of attachment in formula I.

16. The compound of claim 1 , wherein each R a and R b are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C 3-6 cycloalkyl, -3-12 membered heterocyclyl, —C(O)3-12 membered heterocyclyl or —C 6-14 aryl, wherein said alkyl, cycloalkyl, heterocyclyl and aryl are independently optionally substituted by halogen, oxo, —CN, —OR e , —NR e R f , —C(O)R g , —C(O)OR g , —C(O)NR g R h , —NR g C(O)R h , —OC(O)NR g R h , —NR g C(O)NR g R h , —NR g C(O)OR h , —S(O) 1-2 R g , —NR g S(O) 1-2 R h , —S(O) 1-2 NR g R h , —NR g S(O) 1-2 NR g R h , C 3-6 cycloalkyl, 3-6 membered heterocyclyl, phenyl or C 1-3 alkyl optionally substituted by oxo or halogen, or taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by oxo, halogen, —C(O)C 1-6 alkyl or C 1-6 alkyl optionally substituted by oxo, halogen, OR g or NR g NR h .

17. The compound of claim 1 , wherein each R c and R d are independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —C 3-6 cycloalkyl, -3-12 membered heterocyclyl, —C(O) 3-12 membered heterocyclyl or —C 6-14 aryl, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl and aryl are independently optionally substituted by halogen, oxo, —CN, —OR g , —NR g R h , —C(O)R g , —C(O)OR g , —C(O)NR g R h , —NR g C(O)R h , —OC(O)NR g R h , —NR g C(O)NR g R h , —NR g C(O)OR h , —S(O) 1-2 R g , —NR g S(O) 1-2 R h , —S(O) 1-2 NR g R h , —NR g S(O) 1-2 NR g R h , C 3-6 cycloalkyl, 3-6 membered heterocyclyl, phenyl or C 1-6 alkyl optionally substituted by oxo or halogen, or taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by oxo, halogen, —C(O)C 1-6 alkyl or C 1-6 alkyl optionally substituted by oxo or halogen.

18. A pharmaceutical composition comprising a compound of claim 1 , a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.