Sustained release systems of ascorbic acid phosphate
View Patent ↗A novel method of preparing a controlled release composition is disclosed. Specifically, the present invention relates to a method of preparing controlled release compositions of ascorbic acid phosphate and absorbable polymers. Also disclosed is a novel controlled release composition of ascorbic acid phosphate made by the method of the present invention.
1. A controlled release composition, comprising:
a controlled release composition of ascorbic acid phosphate manufactured by the method comprising:
drying ascorbic acid phosphate at a temperature of no greater than 160° C. for about 30 min; and,
melt blending the dried ascorbic acid phosphate with an absorbable aliphatic polyester polymer at a temperature of no greater than about 160° C., thereby forming the ascorbic acid phosphate and polymer composition.
2. The composition of claim 1 , wherein the process comprises the additional step of processing the ascorbic acid and polymer composition into a desired form at a temperature of no greater than about 160° C.
3. The composition of claim 1 , wherein the composition comprises ascorbic acid phosphate in the amount of about 0.5 wt % to about 20 wt %.
4. The composition of claim 1 , wherein the composition comprises ascorbic acid phosphate in the amount of about 2 wt % to about 10 wt %.
5. The composition of claim 1 , wherein the absorbable aliphatic polyester polymer is a homopolymer or copolymer prepared from monomers selected from the group consisting of lactide, glycolide, epsilon-caprolactone, dioxanone, and trimethylene carbonate.
6. The composition of claim 1 , wherein the absorbable aliphatic polyester polymer is a copolymer prepared from epsilon-caprolactone and glycolide.
7. The composition of claim 2 , wherein the composition is formed into a medical device selected from the group consisting of fibers, rods, screws, staples, suture anchors, films and combinations thereof.
8. The composition of claim 1 , wherein the absorbable polymer and the ascorbic acid phosphate are melt blended for about 5 minutes to about 30 minutes.
9. The composition of claim 1 , wherein the composition additionally comprises at least one bioactive agent.
10. The composition of claim 1 , wherein the composition additionally comprises viable tissue.
11. A medical device, comprising:
a controlled release composition of ascorbic acid phosphate manufactured by the method comprising:
drying ascorbic acid phosphate at a temperature of no greater than 160° C. for about 30 min; and,
melt blending the dried ascorbic acid phosphate with an absorbable aliphatic polyester polymer at a temperature of no greater than about 160° C., thereby forming the ascorbic acid phosphate and polymer composition.