Intracameral sustained release therapeutic agent implants
Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.
1. A method for treating elevated intraocular pressure in an eye comprising the steps of:
providing at least two biodegradable sustained release intracameral implants, each implant containing at least one prostamide;
implanting the at least two biodegradable sustained release implants into the anterior chamber of the eye; and
treating the elevated intraocular pressure, wherein each of the at least two biodegradable sustained release implants releases about 100 ng per day to about 900 ng per day of the at least one prostamide over the lifetime of the implant, and wherein the at least two biodegradable sustained release implants each comprise about 5% to about 40% of the least one prostamide, about 10% to about 60% R203S, which is a poly(D,L-lactide) having an inherent viscosity of about 0.25 to about 0.35 dl/g, about 5% to about 20% R202H, which is a poly(D,L-lactide) having an inherent viscosity of about 0.16 to about 0.24 dl/g, about 5% to about 40% RG752S, which is a poly(D,L-lactide-co-glycolide) having a D,L-lactide:glycolide molar ratio of about 73:27 to about 77:23 and an inherent viscosity of about 0.16 to about 0.24 dl/g, and about 5% to about 15% polyethylene glycol (PEG) 3350.
2. The method according to claim 1 , wherein the at least one prostamide is bimatoprost.
3. The method according to claim 1 wherein the at least two biodegradable sustained release implants each comprise about 30% of the at least one prostamide.
4. The method according to claim 1 wherein the implanting step is accomplished using an applicator.
5. The method according to claim 1 , wherein the at least two biodegradable sustained release intracameral implants each comprise about 20% bimatoprost, about 45% R203S, which is a poly(D,L-lactide) having an inherent viscosity of about 0.25 to about 0.35 dl/g, about 10% R202H, which is a poly(D,L-lactide) having an inherent viscosity of about 0.16 to about 0.24 dl/g, about 20% RG752S, which is a poly(D,L-lactide-co-glycolide) having a D,L-lactide:glycolide molar ratio of about 73:27 to about 77:23 and an inherent viscosity of about 0.16 to about 0.24 dl/g, and about 5% polyethylene glycol (PEG) 3350.