Method and nerve stimulator using simultaneous electrical and optical signals
View Patent ↗An apparatus and method for stimulating animal tissue (for example to trigger a nerve action potential (NAP) signal in a human patient) by application of both electrical and optical signals for treatment and diagnosis purposes. The application of an electrical signal before or simultaneously to the application of a NAP-triggering optical signal allows the use of a lower amount of optical power or energy than would otherwise be needed if an optical signal alone was used for the same purpose and effectiveness. The application of the electrical signal may precondition the nerve tissue such that a lower-power optical signal can be used to trigger the desired NAP, which otherwise would take a higher-power optical signal were the electric signal not applied. Some embodiments include an implanted nerve interface having a plurality of closely spaced electrodes placed transversely and/or longitudinally to the nerve and a plurality of optical emitters.
1. A method for triggering a response in a nerve and for in vivo optical-electrical stimulation of a nerve action potential (NAP) in neuronal tissue of a patient, the method comprising:
applying a sub-threshold-for-stimulation amount electrical current through an area of the neuronal tissue; and
applying a pulse of optical energy to a subportion of the area of the neuronal tissue to which the electrical current is applied in order to stimulate a nerve action potential in one or more neurons of the neuronal tissue.
2. The method of claim 1 , wherein the pulse of optical energy has a duration of about 1 msec and is applied prior to the applying of the sub-threshold-for-stimulation amount of electrical current, wherein there is a delay of about 1 msec after the pulse of optical energy ends and before the applying of the sub-threshold-for-stimulation amount of electrical current begins, and wherein the applying of the sub-threshold-for-stimulation amount of electrical current has a duration of about 10 msec.
3. The method of claim 1 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 90% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
4. The method of claim 1 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 80% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
5. The method of claim 1 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 60% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
6. The method of claim 1 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 40% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
7. The method of claim 1 , wherein the pulse of optical energy is applied such that a leading edge half-maximum of the optical pulse occurs at a time delay of about 1 msec after a leading edge half-maximum of the sub-threshold-for-stimulation amount electrical current is applied.
8. The method of claim 1 , wherein the pulse of optical energy is applied such that a leading edge half-maximum of the optical pulse occurs between about 1 msec and about 30 msec, inclusive, after a leading edge half-maximum of the sub-threshold-for-stimulation amount electrical current.
9. The method of claim 1 , wherein the sub-threshold-for-stimulation amount electrical current is applied such that a leading edge half-maximum of the electrical current occurs between about 1 msec and about 30 msec, inclusive, after a leading edge half-maximum the pulse of optical energy.
10. An apparatus for triggering a response in a nerve and for in vivo optical-electrical stimulation of a nerve action potential (NAP) in neuronal tissue of a patient, the apparatus comprising:
means for applying a sub-threshold-for-stimulation amount electrical current through an area of the neuronal tissue; and
means for applying a pulse of optical energy to a subportion of the area of the neuronal tissue to which the electrical current is applied in order to stimulate a nerve action potential in one or more neurons of the neuronal tissue.
11. The apparatus of claim 10 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 90% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
12. The apparatus of claim 10 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 80% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
13. The apparatus of claim 10 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 60% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
14. The apparatus of claim 10 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 40% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
15. The apparatus of claim 10 , wherein the pulse of optical energy stimulation is applied starting at a time delay of about 1 msec after the sub-threshold-for-stimulation amount electrical current pulse is initially applied.
16. An apparatus for triggering a response in a nerve and for in vivo optical stimulation of a nerve action potential (NAP) in neuronal tissue of a patient, the apparatus comprising:
an electrical-stimulation circuit that applies a sub-threshold-for-stimulation amount electrical current through an area of the neuronal tissue; and
an optical-stimulation device that applies a pulse of optical energy to a subportion of the area of the neuronal tissue to which the electrical current is applied in order to stimulate a nerve action potential in one or more neurons of the neuronal tissue.
17. The apparatus of claim 16 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 90% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
18. The apparatus of claim 16 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 80% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
19. The apparatus of claim 16 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 60% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
20. The apparatus of claim 16 , wherein there exists a threshold amount of optical energy needed to stimulate a nerve-action-potential response in the neuronal tissue when no electrical current is applied, and wherein with the application of the amount of electrical current, the optical energy of the optical pulse is less than 40% of the threshold amount of optical energy needed to stimulate a nerve action potential in the neuronal tissue when no electrical current is applied.
21. The apparatus of claim 16 , wherein the pulse of optical energy stimulation is applied starting at a time delay of about 1 msec after the sub-threshold-for-stimulation amount electrical current pulse is initially applied.
22. The apparatus of claim 16 , further comprising a digital-delay generator configured to trigger the optical-stimulation device to apply the pulse of optical energy after a predetermined time delay determined by the digital-delay generator.
23. The apparatus of claim 16 , further comprising a oscilloscope configured to measure an actual delay between the application of the sub-threshold-for-stimulation amount electrical current and the application of the pulse of optical energy.