Emollient foams for treatment of seborrheic dermatitis
View Patent ↗Described herein are emulsions and compositions for the treatment of various dermatoses. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. Also described are methods of treating dermatoses, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition. The dermatosis may be seborrheic dermatitis.
1. A method of treating a dermatosis, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of a composition, wherein the composition comprises:
an emulsion, wherein the emulsion comprises:
cetearyl alcohol, from about 0.5% to about 5% by weight of the emulsion;
dicetyl phosphate, from about 0.5% to about 3% by weight of the emulsion;
ceteareth-10 phosphate, from about 0.3% to about 1.5% by weight of the emulsion;
steareth-10, from about 0.4% to about 2.0% by weight of the emulsion;
2-ethylhexyl palmitate, from about 0.7% to about 9.0% by weight of the emulsion;
shea butter, from about 0.5% to about 3.0% by weight of the emulsion;
dimethicone, from about 0.5% to about 1.5% by weight of the emulsion;
glycyrrhetinic acid, from about 0.3% to about 1.5% by weight of the emulsion;
tocopheryl acetate, from about 0.2% to about 0.8% by weight of the emulsion;
butylated hydroxytoluene, from about 0.05% to about 0.2% by weight of the emulsion;
bisabolol, from about 0.05% to about 2% by weight of the emulsion;
water, from about 60% to about 90% by weight of the emulsion;
pentylene glycol, from about 1.2% to about 3.8% by weight of the emulsion;
glycerol, from about 2% to about 8% by weight of the emulsion;
sodium hyaluronate, from about 0.05% to about 0.2% by weight of the emulsion;
allantoin, from about 0.3% to about 1.2% by weight of the emulsion;
disodium EDTA, from about 0.05% to about 0.2% by weight of the emulsion;
piroctone olamine, from about 0.5% to about 1.5% by weight of the emulsion;
Vitis vinifera extract, from about 0.05% to about 0.2% by weight of the emulsion;
sodium phosphate dibasic, from about 0.14% to about 0.32% by weight of the emulsion; and
citric acid, from about 0.1% to about 0.3% by weight of the emulsion;
a propellant; and
a purge gas.
2. The method of claim 1 , wherein the dermatosis is seborrheic dermatitis.
3. The method of claim 1 , wherein the subject presents with desquamation, erythema, pruritus, inflammation, lichenification, excoriation, stinging, or scaling.
4. The method of claim 1 , wherein the affected area is the scalp, including the hairline, ear canals, or behind the ears; the face, including the eyebrows, nose, or nasolabial folds; and the trunk, including the chest or back.
5. The method of claim 1 , wherein the composition is applied once daily or twice daily.
6. The method of claim 1 , wherein the composition comprises
an emulsion, wherein the emulsion comprises:
cetearyl alcohol, in about 3.0% by weight of the emulsion;
dicetyl phosphate, in about 2.1% by weight of the emulsion;
ceteareth-10 phosphate, in about 0.9% by weight of the emulsion;
steareth-10, in about 1.4% by weight of the emulsion;
2-ethylhexyl palmitate, in about 6.0% by weight of the emulsion;
shea butter, in about 2.0% by weight of the emulsion;
dimethicone, in about 1.0% by weight of the emulsion;
glycyrrhetinic acid, in about 0.1% by weight of the emulsion;
tocopheryl acetate, in about 0.5% by weight of the emulsion;
butylated hydroxytoluene, in about 0.1% by weight of the emulsion;
bisabolol, in about 0.2% by weight of the emulsion;
water, in about 72.7% by weight of the emulsion;
pentylene glycol, in about 2.5% by weight of the emulsion;
glycerol, in about 5.0% by weight of the emulsion;
sodium hyaluronate, in about 0.1% by weight of the emulsion;
allantoin, in about 0.8% by weight of the emulsion;
disodium EDTA, in about 0.1% by weight of the emulsion;
piroctone olamine, in about 1.0% by weight of the emulsion;
Vitis vinifera extract, in about 0.1% by weight of the emulsion;
sodium phosphate dibasic, in about 0.3% by weight of the emulsion; and
citric acid, in about 0.2% by weight of the emulsion;
a propellant; and
a purge gas.
7. The method of claim 1 , wherein the propellant is selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, and combinations/mixtures thereof.
8. The method of claim 1 , wherein the purge gas is selected from the group consisting of nitrogen and argon.