Isocyanate manufacture
View Patent ↗The present invention encompasses the finding that improvements can be achieved in manufacture of isocyanates through the use of a substitute for or a precursor of phosgene. Methods and compositions utilized in accordance with the present invention can be useful in situations in which it is difficult to use phosgene, and in particular gaseous phosgene. In some embodiments, a substitute for or a precursor of phosgene used in accordance with the present invention for preparing isocyanates is or comprises diphosgene (ClCO 2 CCl 3 ).
1. A method of synthesizing an isocyanate comprising a step of reacting a phosgene substitute or precursor with a trihydrochloride salt of an amine.
2. The method of claim 1 , wherein the step of reacting is processed in a two-reactor system.
3. The method of claim 2 , wherein the step of reacting comprises adding the phosgene substitute or precursor in a controlled manner into a suspension of a catalyst to produce phosgene gas in a first reactor.
4. The method of claim 3 , wherein the phosgene substitute or precursor is or comprises diphosgene.
5. The method of claim 3 , wherein the phosgene substitute or precursor is added by a syringe pump or a dropping funnel.
6. The method of claim 3 , wherein the catalyst comprises activated carbon.
7. The method of claim 3 , wherein the suspension in the first reactor is heated and stirred.
8. The method of claim 3 , wherein the suspension in the first reactor is heated to approximately 135° C.
9. The method of claim 3 , wherein the suspension in the first reactor is heated to approximately 125-310° C.
10. The method of claim 3 , wherein the suspension in the first reactor comprises a solvent.
11. The method of claim 10 , wherein the solvent is or comprises o-dichlorobenzene.
12. The method of claim 2 , wherein the step of reacting comprises transferring the phosgene gas produced in the first reactor to a second reactor into a suspension of the trihydrochloride salt of the amine.
13. The method of claim 12 , wherein the suspension in the second reactor is heated and stirred.
14. The method of claim 12 , wherein the suspension in the second reactor is heated to approximately 135° C.
15. The method of claim 12 , wherein the suspension in the second reactor is heated to approximately 125-310° C.
16. The method of claim 12 , wherein the suspension in the second reactor comprises a solvent.
17. The method of claim 16 , wherein the solvent is or comprises o-dichlorobenzene.
18. The method of claim 1 , wherein the step of reacting comprises adding the phosgene substitute or precursor in a controlled manner into a suspension of the trihydrochloride salt of the amine.
19. The method of claim 1 , further the comprising the step of fractionally removing impurity from the synthesized isocyanate by distillation.
20. The method of claim 1 , wherein the trihydrochloride salt of the amine comprises lysine-β-aminoethyl ester trihydrochloride.