Hydrogen peroxide-based skin disinfectant
View Patent ↗A skin disinfectant in ready-to-use concentrated liquid or dry powdered form. Ready-to-use liquid forms have a pH of from about 2 to about 6 and include: (a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w of the solution; (b) at least one surfactant chosen from imidazoline derivatives, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, alkylsulfo betaines, amine oxides and derivatives thereof in a concentration of from about 0.01 to about 15% w/w of the solution; (c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w of the solution; (d) at least one member chosen from cyclic carboxylic acids and salts thereof in a concentration of from about 0.01 to about 4% w/w of the solution; and (e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w of the solution.
1. A method of disinfecting skin comprising applying an aqueous skin disinfecting solution to skin, the solution being suitable for use on skin, having a pH of from about 2 to about 6, and consisting of:
(a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w of the solution;
(b) at least one amine oxide surfactant in a concentration of from about 0.01 to about 15% w/w of the solution;
(c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w of the solution;
(d) salicylic acid in a concentration of from about 0.01 to about 4% w/w of the solution;
(e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w of the solution;
(f) optionally, at least one buffer in a concentration of from about 0.01 to about 5% w/w of the solution;
(g) optionally, at least one thickening agent compatible with hydrogen peroxide in a concentration of from about 0.01 to about 5% w/w of the solution;
(h) optionally, at least one additional surfactant selected from the group consisting of alkyl amphocarboxylates, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, and alkylsulfo betaines, in a concentration of from about 0.01 to about 15% w/w of the solution;
(i) optionally, at least one C1 to C8 alcohol in a concentration of from about 0.01 to about 10% w/w of solution;
(j) optionally, at least one member selected from the group consisting of monocarboxylic acids, polycarboxylic acids, and mixtures thereof in a concentration of from about 0.01 to about 3% w/w of the solution;
(k) optionally, at least one member selected from the group consisting of dyes and fragrances in a concentration of from about 0.001 to about 0.5% w/w of the solution; and
(l) water q.s. to 100% w/w.
2. The method of claim 1 , wherein the pH of the solution is from about 2 to about 4.
3. The method of claim 2 , wherein the solution has a pH from about 2.5 to about 3.5.
4. The method of claim 1 , wherein the skin conditioning agent is selected from the group consisting of glycerin, glycerides, sorbitol, castor oil, allantoin, cationic polymers, lanolin, and cetyl alcohol.
5. The method of claim 4 , wherein the skin conditioning agent is selected from the group consisting of glycerin, castor oil, and cationic polymers.
6. The method of claim 1 , wherein the buffer is present.
7. The method of claim 6 , wherein the buffer is selected from the group consisting of citric acid, lactic acid, glycolic acid, phosphoric acid, malic acid, succinic acid and tartaric acid.
8. The method of claim 1 , wherein the hydrogen peroxide stabilizer is selected from the group consisting of phosphoric acid, phosphonic acids having 1 to 5 phosphonic acid groups, ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), N-(hydroxyethyl)-ethylenediaminetriacetic acid (HEDTA), nitrilotriacetic acid (NTA), 2-hydroxyethyliminodiacetic acid (HEIDA), benzoic acid, aminobenzoic acid, citric acid, iminodisuccinic acid, polyaspartic acid, and salts thereof.
9. The method of claim 8 , wherein the hydrogen peroxide stabilizer is selected from the group consisting of sodium tripolyphosphate, 1-hydroxyethylidene-1,1,-diphosphonic acid, amino tri(methylene phosphonic acid), diethylenetriaminepenta(methylene phosphonic acid), 2-hydroxy ethylimino bis(methylene phosphonic acid), and ethylene diamine tetra(methylene phosphonic acid).
10. The method of claim 1 , wherein the at least one thickening agent compatible with hydrogen peroxide is present.
11. The method of claim 10 , wherein the thickening agent is selected from the group consisting of polyacrylic acid polymers, polysaccharides, and cellulose based polymers.
12. The method of claim 1 , wherein the solution has a hydrogen peroxide concentration of from about 0.25 to about 3% w/w of the solution.
13. The method of claim 1 , wherein the at least one additional surfactant selected from the group consisting of alkyl amphocarboxylates, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, and alkylsulfo betaines, is present.
14. The method of claim 1 , wherein the at least one hydrogen peroxide stabilizer is selected from the group consisting of benzoic acid and phosphoric acid.
15. The method of claim 1 , wherein the at least one additional surfactant is present in a concentration of from about 0.01 to about 10% w/w of the solution.
16. The method of claim 1 , wherein the at least one C1 to C8 alcohol is selected from the group consisting of benzyl alcohol, ethanol, n-butanol, isopropanol, and glycols.
17. The method of claim 1 , wherein the at least one member selected from the group consisting of monocarboxylic acids, polycarboxylic acids, and mixtures thereof is present.
18. The method of claim 1 , wherein the at least one amine oxide is present in a concentration of from about 1 to about 5% w/w of the solution.
19. The method of claim 1 , wherein the at least one hydrogen peroxide stabilizer is present in a concentration of from about 0.01 to about 2% w/w of the solution.
20. The method of claim 1 , wherein the salicylic acid is present in a concentration of from about 0.05 to about 1% w/w of the solution.
21. The method of claim 1 , wherein the at least one skin conditioning agent is present in a concentration of from about 0.5 to about 10% w/w of the solution.
22. The method of claim 1 , wherein the at least one C 1 to C8 alcohol is present.
23. The method of claim 1 , wherein the at least one member selected from the group consisting of dyes and fragrances is present.
24. The method of claim 1 , where the amine oxide has the formula, R1R2R3NO, wherein each of R1, R2, R3 is independently a saturated, substituted or unsubstituted, linear or branched alkyl group having from 1 to 28 carbon atoms.
25. The method of claim 24 , wherein the amine oxide is selected from the group consisting of lauramine oxide and cocamidopropylamine oxide.