Hydrolytically degradable polymers and hydrogels made therefrom
View Patent ↗Methods for delivering a biologically active agent into the body of a mammal are provided, the method comprising administering a carbamate-containing conjugate to the mammal.
1. A method for delivering a biologically active agent into the body of a mammal, comprising administering via injection into a body a carbamate-containing conjugate having the following structure:
X—O—[(CH 2 CH 2 —O) n —CO 2 ] m —(CH 2 CH 2 —O) n —CONH-Protein
wherein:
X is selected from the group consisting of alkyl, alkenyl and aryl,
(n) can range from 2 to 2000;
(m) can range from 2 to 200; and
Protein is both a biologically active agent and a protein having an amino group for formation of the carbamate linkage.
2. The method of claim 1 , wherein X is alkyl.
3. The method of claim 2 , wherein alkyl is methyl.
4. The method of claim 1 , wherein (n) is 5 to 500.
5. The method of claim 1 , wherein (n) is 10 to 50.
6. The method of claim 1 , wherein (m) is 2.