IL-13 receptor antibodies
View Patent ↗This invention relates to monoclonal and polyclonal antibodies capable of specifically recognizing IL-13 receptor α and uses thereof.
1. An isolated antibody that specifically binds to a protein selected from the group consisting of:
(a) a protein consisting of SEQ ID NO:4;
(b) a protein consisting of the extracellular domain of SEQ ID NO:4;
(c) a protein comprising the soluble amino acid residues 1-343 of SEQ ID NO:4; and
(d) a protein comprising SEQ ID NO:4.
2. The antibody of claim 1 which is polyclonal.
3. The antibody of claim 1 which is monoclonal.
4. An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
(a) a protein consisting of SEQ ID NO:4;
(b) a protein consisting of the extracellular domain of SEQ ID NO:4;
(c) a protein comprising the soluble amino acid residues 1-342 of SEQ ID NO:4; and
(d) a protein comprising SEQ ID NO:4 said antibody or fragment thereof selected from the group consisting of:
(a) a chimeric antibody;
(b) a Fab fragment;
(c) a humanized antibody; and
(d) a F(ab′)2 fragment.
5. A process for diagnosis of pathologies correlated with an abnormal expression of IL-13 receptor in a biological sample, comprising the steps of:
(a) contacting said biological sample with at least one antibody according to claims 1 or 3 under conditions allowing the formation of specific immunological complexes between the IL-13 receptor and said antibody and
(b) detecting said immunological complexes which are formed and comparing to a normal control sample.
6. A kit for in vitro diagnosis that measures the level of expression of the IL-13 receptor in a biological sample comprising:
(a) least one antibody specific for IL-13 receptor according to claim 1 or 3 , optionally attached onto a support, and
(b) means for revealing the formation of specific IL-13 receptor/antibody complexes and quantifying said complexes.
7. The antibody of claim 1 , wherein the protein (c) comprises an amino acid selected from the group consisting of:
(a) residues 1-336 of SEQ ID NO: 4;
(b) residues 1-337 of SEQ ID NO: 4;
(c) residues 1-338 of SEQ ID NO: 4;
(d) residues 1-339 of SEQ ID NO: 4;
(e) residues 1-340 of SEQ ID NO: 4;
(f) residues 1-341 of SEQ ID NO: 4;
(g) residues 1-342 of SEQ ID NO: 4; and
(h) residues 1-343 of SEQ ID NO: 4.
8. The antibody of claim 4 , wherein the protein (c) comprises an amino acid selected from the group consisting of:
(a) residues 1-336 of SEQ ID NO: 4;
(b) residues 1-337 of SEQ ID NO: 4;
(c) residues 1-338 of SEQ ID NO: 4;
(d) residues 1-339 of SEQ ID NO: 4;
(e) residues 1-340 of SEQ ID NO: 4;
(f) residues 1-341 of SEQ ID NO: 4;
(g) residues 1-342 of SEQ ID NO: 4; and
(h) residues 1-343 of SEQ ID NO: 4.