DHA Ester Emulsions

1 . An emulsion comprising an emulsifier, an isotonic agent and an oil comprising docosahexaenoic acid ethyl ester (DHA-EE), wherein the emulsion is substantially free of eicosapentaenoic acid (EPA) and is suitable for parenteral administration.

2 . The emulsion as recited in claim 1 , wherein the concentration of the DHA-EE is greater than or equal to about 150 mg/ml of the emulsion.

3 . The emulsion as recited in claim 2 wherein the concentration of the DHA-EE is about 250 to about 290 mg/ml of the emulsion.

4 . The emulsion as recited in claim 3 , wherein the concentration of the DHA-EE is about 270 mg/ml of the emulsion.

5 . The emulsion as recited in claim 1 , wherein the mean particle size of the emulsion is less than about 500 nanometers.

6 . The emulsion as recited in claim 1 , wherein the emulsion comprises about 0.6% to about 10%, by weight, of the emulsifier.

7 . The emulsion as recited in claim 6 , wherein the emulsion comprises about 1% to about 4%, by weight of the emulsifier.

8 . The emulsion as recited in claim 1 , wherein the emulsion comprises about 1% to about 2.5% by weight of the isotonic agent.

9 . The emulsion as recited in claim 8 , wherein the emulsion comprises about 2.25% to about 2.5% by weight of the isotonic agent.

10 . The emulsion as recited in claim 1 , wherein the emulsion is substantially free of arachidonic acid (ARA).

11 . The emulsion as recited in claim 1 , wherein the emulsion comprises about 30% by weight of the oil.

12 . The emulsion as recited in claim 10 , wherein the oil comprises about 84% to about 95% DHA-EE of the total weight of the oil.

13 . The emulsion as recited in claim 12 , wherein the oil comprises about 90% DHA-EE of the total weight of the oil.

14 . The emulsion as recited in claim 1 , wherein the isotonic agent comprises glycerin.

15 . The emulsion as recited in claim 1 , wherein the emulsifier is selected from the group consisting of lecithins.

16 . The emulsion as recited in claim 1 , comprising a secondary emulsifier in an amount from about 0.03% to about 0.4%, by weight, of the emulsion.

17 . The emulsion as recited in claim 16 , wherein the secondary comprises about 0.03% to about 0.3%, by weight, of the emulsion.

18 . The emulsion as recited in claim 17 , wherein the secondary emulsion comprises about 0.3%, by weight, of the emulsion.

19 . The emulsion as recited in claim 16 , where the secondary emulsifier is selected from the group consisting of linoleic acid, linolenic acid, oleic acid, and palmitic acid or their pharmaceutically acceptable salts.

20 . The emulsion as recited in claim 17 , wherein the secondary emulsifier is selected from the group consisting of linoleic acid, linolenic acid, oleic acid, and palmitic acid or their pharmaceutically acceptable salts.

21 . The emulsion as recited in claim 18 , wherein the secondary emulsifier is selected from the group consisting of linoleic acid, linolenic acid, oleic acid, and palmitic acid or their pharmaceutically acceptable salts.

22 . The emulsion as recited in claim 19 , wherein the secondary emulsifier is sodium oleate.

23 . The emulsion as recited in claim 20 , wherein the secondary emulsifier is sodium oleate.

24 . The emulsion as recited in claim 21 , wherein the secondary emulsifier is sodium oleate.

25 . The emulsion as recited in claim 1 , further comprising an oil comprising a triglyceride.

26 . The emulsion as recited in claim 25 , wherein the oil comprising a triglyceride is about 0.5% to about 3.3%, by weight of the emulsion.

27 . The emulsion as recited in claim 26 , wherein the oil comprising a triglyceride is about 3.3%, by weight of the emulsion.

28 . An emulsion comprising about 250 to about 290 milligrams of DHA-EE per milliliter of the emulsion; about 18 milligrams of a lecithin per milliliter of the emulsion; and about 25 milligrams of glycerin per milliliter of the emulsion wherein the emulsion has a mean particle size of about 100 to about 300 nanometers and wherein the emulsion is substantially free of EPA and is suitable for parenteral administration.

29 . The emulsion as recited in claim 28 , further comprising about 0.3 milligrams per milliliter of sodium oleate.

30 . The emulsion as recited in claim 29 , further comprising about 3.3% by weight, an oil comprising a triglyceride.