EXTRACELLULAR MATRIX COMPOSITIONS FOR TISSUE REGENERATION
The invention is compositions of extracellular matrix that comprise mammalian extracellular matrix from two or more tissue sources in a mammal. The invention also includes methods of using these compositions to regenerate tissue or generate new tissue at sites of defects or wounds in mammals.
1 . A composition comprising mammalian extracellular matrix from small intestine submucosa (SIS) and a mammalian extracellular matrix selected from one or more tissue sources selected from the group consisting of stomach submucosa (SS) and urinary bladder submucosa (UBS).
2 . The composition of claim 1 , wherein the composition comprises mammalian extracellular matrix from SIS and SS.
3 . The composition of claim 1 , wherein the composition comprises mammalian extracellular matrix from SIS and UBS.
4 . The composition of claim 1 , further comprising a cell.
5 . The composition of claim 1 , further comprising a protein.
6 . The composition of claim 1 , further comprising a drug.
7 . A method comprising
(a) identifying a site of defect or wound in mammalian tissue,
(b) providing a composition comprising mammalian extracellular matrix from small intestine submucosa (SIS) and a mammalian extracellular matrix selected from one or more tissue sources selected from the group consisting of stomach submucosa (SS) and urinary bladder submucosa (UBS),
(c) contacting said site with a therapeutically effective amount of said composition, and
(d) regenerating tissue or generating new tissue at said site thereby.