Compositions and methods of delivery of pharmacological agents
View Patent ↗The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. He human serum albumin is present in an amount effective to reduce one or more side effects associated with administration of the pharmaceutical composition. The inventor also provides methods for reducing on or more side effects of administration of the pharmaceutical composition, and methods for enhancing transport and binding of a pharmaceutical agent to a cell.
1. A method of treating lung cancer in a human individual, comprising injecting into the individual an effective amount of a pharmaceutical composition comprising paclitaxel and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier comprises albumin, wherein the albumin and the paclitaxel in the composition are formulated as particles, wherein the particles in the composition have a particle size of less than about 200 nm, and wherein the weight ratio of albumin to paclitaxel in the composition is about 1:1 to about 9:1.
2. The method of claim 1 , wherein the albumin is human serum albumin.
3. The method of claim 1 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is 1:1 to 9:1.
4. The method of claim 1 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is about 9:1.
5. The method of claim 2 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is 1:1 to 9:1.
6. The method of claim 2 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is about 9:1.
7. The method of claim 1 , wherein the pharmaceutical composition is injected intravenously.
8. The method of claim 2 , wherein the pharmaceutical composition is injected intravenously.
9. The method of claim 3 , wherein the pharmaceutical composition is injected intravenously.
10. The method of claim 4 , wherein the pharmaceutical composition is injected intravenously.
11. The method of claim 5 , wherein the pharmaceutical composition is injected intravenously.
12. The method of claim 6 , wherein the pharmaceutical composition is injected intravenously.
13. A method of treating pancreatic cancer in a human individual, comprising injecting into the individual an effective amount of a pharmaceutical composition comprising paclitaxel and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier comprises albumin, wherein the albumin and the paclitaxel in the composition are formulated as particles, wherein the particles in the composition have a particle size of less than about 200 nm, and wherein the weight ratio of albumin to paclitaxel in the composition is about 1:1 to about 9:1.
14. The method of claim 13 , wherein the albumin is human serum albumin.
15. The method of claim 13 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is 1:1 to 9:1.
16. The method of claim 13 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is about 9:1.
17. The method of claim 14 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is 1:1 to 9:1.
18. The method of claim 14 , wherein the ratio (w/w) of the albumin to the paclitaxel in the pharmaceutical composition is about 9:1.
19. The method of claim 13 , wherein the pharmaceutical composition is injected intravenously.
20. The method of claim 14 , wherein the pharmaceutical composition is injected intravenously.
21. The method of claim 15 , wherein the pharmaceutical composition is injected intravenously.
22. The method of claim 16 , wherein the pharmaceutical composition is injected intravenously.
23. The method of claim 17 , wherein the pharmaceutical composition is injected intravenously.
24. The method of claim 18 , wherein the pharmaceutical composition is injected intravenously.