Patterned neo-epithelialization dressings, systems, and methods

1. A patterned neo-epithelium dressing for treating an epithelial tissue site having granulation tissue, the patterned neo-epithelium dressing comprising:

an interface member having a first side and a second, patient-facing side for placing proximate to the granulation tissue; and

a plurality of three-dimensional features patterned after at least one of an epithelial and endothelial lining having an intact analogous skin pattern and formed on the second, patient-facing side of the interface member;

wherein the interface member is not adherent to the epithelial tissue site so as to be removable from the epithelial tissue site after the treating.

2. The patterned neo-epithelium dressing of independent claim 1 , wherein the interface member is formed with a fluid passageway that fluidly couples the first side and the second, patient-facing side.

3. The patterned neo-epithelium dressing of independent claim 1 , wherein the interface member has a plurality of pores having an average pore size greater than 5 μm and smaller than 1000 μm.

4. The patterned neo-epithelium dressing of independent claim 1 , wherein the plurality of three-dimensional features comprise a location-specific skin pattern.

5. The patterned neo-epithelium dressing of independent claim 1 , wherein the interface member comprises a medical-grade polymer.

6. The patterned neo-epithelium dressing of independent claim 1 , wherein the interface member comprises a thin member bonded to a foam.

7. The patterned neo-epithelium dressing of independent claim 1 , wherein the interface member comprises:

a thin member having a first side and a second, patient-facing side;

a hydrophilic material having a first side and a second, patient-facing side; and

wherein the second, patient-facing side of the hydrophilic material is coupled to the first side of the thin member.

8. The patterned neo-epithelium dressing of independent claim 1 , further comprising a protein coated on the plurality of three-dimensional features.

9. A method of treating a tissue site of a patient, the method comprising:

locating granulation tissue at the tissue site;

deploying a patterned neo-epithelium dressing comprising:

an interface member having a first side and a second, patient-facing side for placing proximate the granulation tissue; and

a plurality of three-dimensional features formed on the second, patient-facing side of the interface member, wherein the plurality of three-dimensional features comprise ridges and are patterned after at least one of an epithelial and endothelial lining;

applying a contact pressure on the patterned neo-epithelium dressing;

allowing formation of neo-epithelium tissue under the influence of the patterned neo-epithelium dressing; and

removing the neo-epithelium dressing from the tissue.

10. The method of independent claim 9 , further comprising promoting formation of granulation tissue using reduced pressure.

11. The method of claim 10 , wherein the promoting the formation of granulation tissue comprises applying a reduced-pressure manifold proximate to the tissue site, covering the reduced-pressure manifold with a sealing member, and providing reduced pressure to the reduced-pressure manifold.

12. The method of independent claim 9 , wherein applying the contact pressure comprises:

deploying a sealing member over the patterned neo-epithelium dressing and a portion of the patient's skin, the sealing member having a first side and a second, patient-facing side; and

providing reduced pressure to the second, patient-facing side of the sealing member.

13. The method of independent claim 9 , wherein applying the contact pressure comprises deploying a pressure wrap over the first side of the patterned neo-epithelium dressing.

14. The method of independent claim 9 , wherein the interface member has a plurality of pores having an average pore size greater than 5 μm and smaller than 1000 μm.

15. A system for treating a skin tissue site having granulation tissue on a patient, the system comprising:

a patterned neo-epithelium dressing for disposing proximate to granulation tissue on the tissue site, wherein the patterned neo-epithelium dressing comprises:

an interface member comprising a medical-grade polyurethane film bonded to a foam having a first side and a second, patient-facing side for placing proximate the granulation tissue;

a fluid passageway that fluidly couples the first and second sides of the interface member for delivery of pressure to the second side; and

a plurality of three-dimensional features patterned after at least one of an epithelial and endothelial lining having an intact analogous skin pattern and formed on the second, patient-facing side of the interface member;

a sealing member for placing over the patterned neo-epithelium dressing and the patient's epidermis;

a reduced-pressure interface fluidly coupled to the sealing member; and

a reduced-pressure source fluidly coupled to the reduced-pressure interface;

wherein the interface member is not adherent to the skin tissue site so as to be removable from the skin tissue site after the treating.

16. The system of independent claim 15 , wherein the fluid passageway is formed through the interface member.

17. The system of independent claim 15 , wherein the interface member comprises a plurality of pores having an average pore size larger than 5 μm and smaller than 1000 μm.

18. The system of independent claim 15 , wherein the plurality of three-dimensional features comprise a location-specific skin pattern.

19. The system of independent claim 15 , wherein the foam comprises rigid portions and less rigid portions, wherein, under reduced pressure, the less rigid portions compress more than the more rigid portions.

20. The system of independent claim 15 , further comprising a protein coated on the plurality of three-dimensional features.