Visceral fat measurement
View Patent ↗Dual-energy absorptiometry is used to estimate visceral fat metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing visceral fat as well as subcutaneous fat, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the visceral fat in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large “abdominal” region and a smaller “abdominal cavity” region. Two boundaries of the “abdominal cavity” region are placed at positions associated with the left and right innermost extent of the abdominal muscle wall by identifying inflection of % Fat values. The regions are combined in an equation that is highly correlated with VAT measured by quantitative computed tomography in order to estimate VAT.
1. A method comprising:
acquiring x-ray measurements using a dual-energy x-ray absorptiometry (DXA) system for respective pixel positions related to a two-dimensional projection image of a portion of a subject's abdomen, wherein at least some of the measurements are dual-energy x-ray measurements;
placing a plurality of regions of the image in which the image is obtained using the DXA system, wherein said placing includes placing a first region of the image which extends from a first side of the abdomen to a second side of the abdomen, and placing a second region which extends across an inner abdominal cavity from the first side to the second side between innermost extents of an abdominal muscle wall, and wherein said placing of said second region of the image includes identifying a left and a right innermost extent of abdominal muscle wall by identifying inflection of adipose tissue values;
computer processing to combine the plurality of regions to provide an estimate of visceral fat (VAT) in which said estimate of visceral fat is distinguishable from subcutaneous fat (SAT), wherein said computer processing includes computer processing at least some of the x-ray measurements for placing the second region of the image; and
providing and displaying selected results related to said estimate of visceral fat in which said selected results of visceral fat is distinguishable from subcutaneous fat.
2. The method of claim 1 including combining the plurality of regions in a linear equation using constants that provide correlation between DXA VAT and VAT measured by computed tomography.
3. The method of claim 1 including combining the plurality of regions using polynomial expansion.
4. The method of claim 1 wherein said second region is exclusive of a third region which is placed where bone is present and percent fat cannot be directly measured.
5. The method of claim 1 including using an anatomical landmark and a preselected region of interest line for placing the first region of the image.
6. The method of claim 1 including combining the first region and the second region in a linear equation that is correlated with VAT measured by quantitative computed tomography for processing the first and second regions to provide an estimate of visceral fat.
7. The method of claim 6 including calculating visceral fat as:
J *second region Mass− K *(first region Mass−second region Mass)+ b.
8. The method of claim 7 including selecting constants J and K that provide correlation between DXA VAT and VAT measured by computed tomography, and wherein b is an intercept term.
9. The method of claim 7 including selecting a value for at least one of J, K and b for the subject.
10. The method of claim 9 including selecting a value for at least one of J, K and b based on at least one of age, gender, ethnicity, weight, height, body mass index, waist circumference, and other anthropomorphic variables of the subject.
11. Apparatus comprising:
a data acquisition unit including a dual-energy x-ray absorptiometry (DXA) scanner that acquires x-ray measurements for respective pixel positions related to a two-dimensional projection image of a portion of a subject's abdomen, wherein at least some of the measurements are dual-energy x-ray measurements;
a memory in which is placed a plurality of regions of the image in which the image is obtained using the DXA scanner, wherein the plurality of regions of the image includes a first region and a second region, the first region extending from a first side of the abdomen to a second side of the abdomen, and the second region extending across an inner abdominal cavity wall from the first side to the second side between innermost extents of an abdominal muscle wall;
a processing unit that computer-processes the regions to provide an estimate of visceral fat (VAT) in which said estimate of visceral fat is distinguishable from subcutaneous fat (SAT), wherein the processing unit places the second region of the image by computer-processing at least some of the x-ray measurements and wherein the processing unit uses an algorithm to identify a left and a right innermost extent of abdominal muscle wall by identifying inflection of adipose tissue values for placing the second region of the image; and
a display unit that provides and displays selected results related to visceral fat of the subject in which said selected results of visceral fat is distinguishable from subcutaneous fat.
12. The apparatus of claim 11 wherein the processing unit combines the plurality of regions in a linear equation using constants that provide correlation between DXA VAT and VAT measured by computed tomography.
13. The apparatus of claim 11 wherein the processing unit combines the plurality of regions using polynomial expansion.
14. The apparatus of claim 11 wherein the plurality of regions of the image further includes a third region which is placed where bone is present and percent fat cannot be directly measured.
15. The apparatus of claim 11 wherein the processing unit places the first region of the image by computer-processing at least some of the x-ray measurements.
16. The apparatus of claim 15 wherein the processing unit uses an anatomical landmark and a preselected region of interest line to place the first region of the image.
17. The apparatus of claim 11 wherein the processing unit combines the first region and the second region using a linear equation which is correlated with VAT measured by quantitative computed tomography.
18. The apparatus of claim 17 wherein the processing unit calculates visceral fat as:
J *second region Mass− K *(first region Mass−second region Mass)+ b.
19. The apparatus of claim 18 wherein constants J and K are selected based on correlation between DXA VAT and VAT measured by computed tomography, and wherein b is an intercept term.
20. The apparatus of claim 18 wherein at least one of J, K and b are selected for the subject.
21. The apparatus of claim 20 wherein at least one of J, K and b are selected based on at least one of age, gender, ethnicity, weight, height, body mass index, waist circumference, and other anthropomorphic variables of the subject.