Waterproof stretchable optoelectronics
Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful for construction of fluid monitors, permitting sensitive detection of fluid refractive index and composition. Co-integration of flexible LED arrays with flexible photodetector arrays is useful for construction of flexible proximity sensors. Application of stretchable LED arrays onto flexible threads as light emitting sutures provides novel means for performing radiation therapy on wounds.
1. A biomedical device for treating a tissue in a biological environment, the biomedical device comprising:
a suture having an external surface;
a flexible or stretchable electronic circuit supported by said external surface of said suture, said flexible or stretchable electronic circuit comprising one or more inorganic semiconductor elements having an average thickness less than or equal to 100 μm, wherein said external surface of the suture is in conformal and physical contact with at least a portion of the flexible or stretchable electronic circuit; and
a barrier layer at least partially encapsulating said flexible or stretchable electronic circuit, wherein said barrier layer prevents water from said biological environment from contacting at least a portion of said inorganic semiconductor elements.
2. The device of claim 1 , wherein said suture comprises a fiber or a thread.
3. The device of claim 1 , wherein said suture comprises a biocompatible material, a bioinert material or a combination of a biocompatible material and a bioinert material; or wherein said barrier layer comprises a biocompatible material, a bioinert material or a combination of a biocompatible material and a bioinert material; or wherein both said suture and said barrier layer independently comprise a biocompatible material, a bioinert material or a combination of a biocompatible material and a bioinert material.
4. The device of claim 1 , wherein said suture comprises a material selected from the group consisting of: a biopolymer, a protein, a peptide, a carbohydrate, a polynucleotide, a synthetic polymer, a polysaccharide, an elastomer, and any combination of these; or wherein said barrier layer comprises a material selected from the group consisting of: a biopolymer, a protein, a peptide, a carbohydrate, a polynucleotide, a synthetic polymer, a polysaccharide, an elastomer, and any combination of these; or wherein both said suture and said barrier layer independently comprise a material selected from the group consisting of: a biopolymer, a protein, a peptide, a carbohydrate, a polynucleotide, a synthetic polymer, a polysaccharide, an elastomer, and any combination of these.
5. The device of claim 4 , wherein said suture comprises a material selected from the group consisting of: silk, poly(glycerol-sebacate) (PGS), polydioxanone, poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), collagen, chitosan, fibroin, silkworm fibroin, modified silkworm fibroin, spider silk, insect silk, recombinant silk, and any combination of these; or wherein said barrier layer comprises a material selected from the group consisting of: silk, poly(glycerol-sebacate) (PGS), polydioxanone, poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), collagen, chitosan, fibroin, silkworm fibroin, modified silkworm fibroin, spider silk, insect silk, recombinant silk, and any combination of these; or wherein both said suture and said barrier layer independently comprise a material selected from the group consisting of: silk, poly(glycerol-sebacate) (PGS), polydioxanone, poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), collagen, chitosan, fibroin, silkworm fibroin, modified silkworm fibroin, spider silk, insect silk, recombinant silk, and any combination of these.
6. The device of claim 1 , wherein said barrier layer provides a net permeability with respect to transport of water in said biological environment to said flexible or stretchable device low enough to prevent an electrical short circuit in said flexible or stretchable electronic circuit or wherein said barrier layer provides a net leakage current from said flexible or stretchable electronic circuit to said tissue of 10 μA or less or 0.1 μA/cm 2 or less.
7. The device of claim 1 , wherein said barrier layer is a microstructured or nanostructured layer having one or more microstructured or nanostructured openings, channels, vias, optically transmissive regions, optically opaque regions or selectively permeable regions that are permeable to one or more target molecules.
8. The device of claim 1 , wherein said one or more inorganic semiconductor elements each independently comprise a component selected from the group consisting of a transistor, a diode, an amplifier, a multiplexer, a light emitting diode, a laser, a photodiode, an integrated circuit, a sensor, a temperature sensor, a thermistor, a heater, a resistive heater and an actuator.
9. The device of claim 1 , wherein said flexible or stretchable electronic circuit comprises a flexible or stretchable array of light emitting diodes (LEDs) comprising a plurality of LEDs in electrical communication with a plurality of stretchable or flexible electrical interconnects.
10. The device of claim 9 , wherein said stretchable or flexible array of LEDs comprises a multilayer structure comprising a plurality of individually encapsulated LED array layers provided in a multilayer stacked geometry.
11. The device of claim 10 , wherein said individually encapsulated LED array layers are laterally offset so as to provide a fill factor greater than 1×10 −6 or selected over the range of 1×10 −6 to 1×10 −3 .
12. The device of claim 9 , wherein said stretchable or flexible array of LEDs comprises 2 to 1,000 individually encapsulated LED array layers provided in a multilayer laminated geometry.
13. The device of claim 9 , wherein said stretchable or flexible array of LEDs has a density of LEDs selected from the range of 1 LED mm −2 to 1000 LEDs mm −2 .
14. The device of claim 9 , wherein an ON/OFF state of each LED within said flexible or stretchable array of LEDs is independent from ON/OFF states of other LEDs within said flexible or stretchable array of LEDs.
15. The device of claim 1 further comprising one or more temperature sensors or one or more heaters supported by said external surface of said suture.
16. The device of claim 1 further comprising one or more pharmaceutical compositions, wherein said one or more pharmaceutical compositions are at least partially encapsulated or otherwise incorporated into said barrier layer.
17. The device of claim 16 , wherein said one or more pharmaceutical compositions are selected from the group consisting of: an antibiotic, an antiseptic, a protein, a nucleic acid, an anti-inflammatory, a carbohydrate, an analgesic, an antipyretic, an anti-fungal, an antihistamine, a hormone, an antiviral, a vitamin, an antibody, a photosensitizer and any combination of these.
18. The device of claim 16 , wherein said barrier layer comprises a bioresorbable material, and wherein at least a portion of said one or more pharmaceutical compositions is released upon at least partial resorption or dissolution of said bioresorbable material.
19. The device of claim 16 , wherein said flexible or stretchable electronic circuit comprises a thermal, electrical or optical actuator, and wherein at least a portion of said one or more pharmaceutical compositions is released to said biological environment upon thermal, optical or electrical actuation of said barrier layer.
20. A method of treating a tissue in a biological environment, the method comprising the steps of:
providing said tissue; and
contacting said tissue with a biomedical device, thereby treating said tissue; said biomedical device comprising:
a suture having an external surface;
a flexible or stretchable electronic circuit supported by said external surface of said suture, said flexible or stretchable electronic circuit comprising one or more inorganic semiconductor elements having an average thickness less than or equal to 100 μm, wherein said external surface of the suture is in conformal and physical contact with at least a portion of the flexible or stretchable electronic circuit; and
a barrier layer at least partially encapsulating said flexible or stretchable electronic circuit, wherein said barrier layer prevents water from said biological environment from contacting at least a portion of said inorganic semiconductor elements.
21. The method of claim 20 , wherein said tissue has an opening, a wound or a surgical incision, wherein said step of contacting said tissue with said biomedical device comprises closing said opening, said wound or said surgical incision.
22. The method of claim 20 , further comprising a step of actuating or sensing said tissue in contact with said biomedical device.
23. The method of claim 20 , wherein said flexible or stretchable electronic circuit comprises an array of light emitting diodes for generating electromagnetic radiation, and said method further comprises a step of exposing said tissue to said electromagnetic radiation.
24. The method of claim 20 , wherein said biomedical device further comprises one or more pharmaceutical compositions, wherein said pharmaceutical compositions are at least partially encapsulated or otherwise incorporated into said barrier layer; said method further comprising a step of thermally, optically or electrically actuating said barrier layer to release said one or more pharmaceutical compositions to said biological environment.
25. The method of claim 24 , further comprising a step of actuating one or more of said inorganic semiconductor elements to change a permeability of, degrade or melt at least a portion of said barrier layer, thereby releasing at least a portion of said one or more pharmaceutical compositions to said biological environment.
26. A method of performing therapy on a wound of a tissue, the method comprising the steps of:
providing said tissue having said wound;
contacting said wound with a biomedical device, said biomedical device comprising:
a suture having an external surface;
a flexible or stretchable array of light emitting diodes supported by said external surface of said suture, said flexible or stretchable array of light emitting diodes comprising a plurality of inorganic light emitting diodes each having an average thickness less than or equal to 100 μm, wherein said external surface of the suture is in conformal and physical contact with at least a portion of the flexible or stretchable electronic circuit; and
a barrier layer at least partially encapsulating said flexible or stretchable electronic circuit, wherein said barrier layer prevents water from said biological environment from contacting at least a portion of said inorganic light emitting diodes; and
exposing said wound with electromagnetic radiation generated by said flexible or stretchable array of light emitting diodes.