Methods of administering pirfenidone therapy
View Patent ↗The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
1. A method of administering pirfenidone and fluvoxamine concurrently to a patient in need thereof comprising administering a therapeutically effective amount of fluvoxamine to the patient and administering a therapeutically effective amount of pirfenidone to the patient, wherein the amount of the pirfenidone is about 801 mg/day.
2. The method of claim 1 wherein the pirfenidone is administered three times per day.
3. The method of claim 2 wherein the patient has idiopathic pulmonary fibrosis (IPF).
4. The method of claim 3 wherein the pirfenidone is administered to the patient with food.
5. The method of claim 1 further comprising discontinuing co-administration of fluvoxamine and administering a therapeutically effective amount of pirfenidone.
6. A method of providing pirfenidone therapy to a patient in need thereof comprising titrating the dosage of pirfenidone administered to the patient downward from a dose of about 2400 mg/day, while co-administering fluvoxamine, wherein the dose of pirfenidone is reduced by about 1600 mg/day.
7. The method of claim 6 wherein about 800 mg/day of pirfenidone is administered to the patient.
8. The method of claim 6 wherein the pirfenidone is administered three times per day.
9. The method of claim 8 wherein the patient has idiopathic pulmonary fibrosis (IPF).
10. The method of claim 9 wherein the pirfenidone is administered to the patient with food.
11. The method of claim 6 further comprising discontinuing co-administration of fluvoxamine and administering about 2400 mg/day of pirfenidone.