IP Library Granted Patent US 8,575,308
Granted Patent B2
US 8,575,308 · App. 13/053,996 · Granted Nov 5, 2013

Method for cancer immunotherapy

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Quick Facts
Patent No.
US 8,575,308
App. No.
13/053,996
Granted
Nov 5, 2013
Kind
B2
Abstract

A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R 1 is a hydrogen atom or the like; R 2 is a hydroxy group or the like; R 3 is a hydrogen atom, alkyl group, amino group or the like; R 4 is a hydrogen atom, alkyl group, carboxy group or the like; m is 1 or 2; and n is an integer of 0 to 2, with the proviso that when n is 0, R 3 is a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof, and its use in cancer immunotherapy.

Claims (19)

1. A method for treating cancer, the method comprising:

administering to a subject in need thereof who is positive for HLA-A24 and positive for WT1 protein a therapeutically effective amount of a compound of formula (1) or a pharmaceutically acceptable salt thereof;

wherein formula (1) is:

wherein X is a tyrosine residue or a methionine residue; each of Y and Z is independently selected from the group consisting of a single bond and a divalent peptide group consisting of 1-10 amino acid residues,

R 1 is hydrogen or alkyl,

R 2 is hydroxyl, amino, alkylamino or dialkylamino,

R 3 is hydrogen, alkyl, amino, alkylamino, dialkylamino or substituted or unsubstituted alkylcarbonylamino,

R 4 is hydrogen, alkyl, carboxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl or a group of formula (2):

wherein:

W is an amino acid residue,

m is 1 or 2, and

n is an integer of 0-2,

with the proviso that when n is 0, then R 3 is hydrogen or alkyl.

2. The method of claim 1 that comprises administering a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen.

3. The method of claim 1 that comprises administering a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R 3 is amino, alkylcarbonylamino or substituted alkylcarbonylamino.

4. The method of claim 1 that comprises administering a compound of formula (1) or a pharmaceutically acceptable salt thereof

wherein the compound is:

5. The method of claim 1 that comprises administering a compound of formula (1) or a pharmaceutically acceptable salt thereof wherein the compound is:

6. The method of claim 1 , wherein cancer cells of the subject express WT1 protein.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 4, 2025
From: SUMITOMO PHARMA CO., LTD.
To: INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC.
Reel/Frame 072160/0981 →
CHANGE OF NAME Recorded Jun 10, 2022
From: SUMITOMO DAINIPPON PHARMA CO., LTD.
To: SUMITOMO PHARMA CO., LTD.
Reel/Frame 060161/0046 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 25, 2016
From: CHUGAI SEIYAKU KABUSHIKI KAISHA
To: SUMITOMO DAINIPPON PHARMA CO., LTD.
Reel/Frame 038364/0495 →
CHANGE OF NAME Recorded Oct 10, 2014
From: DAINIPPON SUMITOMO PHARMA CO., LTD.
To: SUMITOMO DAINIPPON PHARMA CO., LTD.
Reel/Frame 033969/0194 →