HEATING OF POLYMERS AND OTHER MATERIALS USING RADIATION FOR DRUG DELIVERY AND OTHER APPLICATIONS
The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using infrared or near-infrared radiation. Such systems and methods may be useful, for example in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation-sensitive material to radiation such as infrared or near-infrared radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna may be used to focus infrared or near- infrared radiation on an article. For instance, the receive antenna may focus infrared or near-infrared radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
1 . An article comprising a radiation-sensitive polymer and a releasable species releasable upon application of infrared and/or near-infrared radiation to at least a portion of the radiation-sensitive polymer.
2 . The article of claim 1 , wherein the radiation-sensitive polymer can be heated by at least about 0.5° C., in the absence of water, by directing infrared or near-infrared radiation at the radiation-sensitive polymer having a transmit power level of no more than about 1 kW/m 2 .
3 . (canceled)
4 . The article of claim 1 , wherein the article at least partially defines an enclosure containing the releasable species.
5 . The article of claim 4 , wherein the enclosure contains an aqueous solution containing the releasable species.
6 . The article of claim 4 , wherein the enclosure contains a controlled release formulation containing the releasable species.
7 . The article of claim 4 , wherein the enclosure is a particle.
8 . The article of claim 4 , wherein the enclosure is isolated, at least in part, by a heat-sensitive material in thermal communication with the radiation-sensitive polymer.
9 . The article of claim 8 , wherein the heat-sensitive material comprises a gel.
10 - 13 . (canceled)
14 . The article of claim 4 , wherein the enclosure contains a sensor, and the sensor is able to determine an analyte that is able to permeate the heat-sensitive material.
15 . The article of claim 1 , wherein the article further comprises a heat-sensitive material in thermal communication with the radiation-sensitive polymer.
16 . The article of claim 1 , wherein the article exhibits an increase of at least about 10% in the release of releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of the infrared and/or near-infrared radiation.
17 . The article of claim 1 , wherein heating the radiation-sensitive polymer by at least about 0.5° C. causes the article to exhibit an increase of at least about 10% in the release of the releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of heating.
18 . The article of claim 1 , wherein the article further contains a receive antenna.
19 - 23 . (canceled)
24 . An article comprising a releasable species and a radiation-sensitive material, sensitive to infrared and/or near-infrared radiation, wherein, when the radiation-sensitive material is heated by at least about 0.5° C., release of the releasable species from the article increases by at least about 10%, relative to the amount of release of the releasable species from the article in the absence of heating of the radiation-sensitive material.
25 - 26 . (canceled)
27 . The article of claim 24 , wherein the radiation-sensitive material can be heated by at least about 0.5° C., in the absence of water, by directing infrared and/or near-infrared at the radiation-sensitive material having a transmit power level of no more than about 1 kW/m 2 .
28 . (canceled)
29 . The article of claim 24 , wherein the article at least partially defines an enclosure containing the releasable species.
30 . The article of claim 29 , wherein the enclosure is isolated, at least in part, by a heat-sensitive material in thermal communication with the radiation-sensitive material.
31 - 32 . (canceled)
33 . The article of claim 24 , wherein the article further comprises a heat-sensitive material in thermal communication with the radiation-sensitive material.
34 . The article of claim 24 , wherein the article exhibits an increase of at least about 10% in the release of releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of heating.
35 - 53 . (canceled)
54 . An article, comprising:
a membrane having a first permeability when infrared and/or near-infrared radiation is applied to the membrane, and a second permeability in the absence of the infrared and/or near-infrared radiation.
55 - 62 . (canceled)