Therapeutic compounds

1. A compound of formula I:

wherein:

either X and Y are both N and Z is C, or X and Z are both N and Y is C;

L 1 is selected from —(C≡C)(C═O)NH—, —(C≡C)(CH 2 ) 2 NH—, —(C≡C) 2 —, —(C≡C)—, —(C≡C)(CHOH)—, —(C≡C)(CH 2 )NH(C═O)—, or —(C≡C)(CH 2 )NH(C═O)—;

a is 1 or 2;

b is 0 or 1;

c is 0 or 1;

d is 0, 1, 2, 3, 4, 5 or 6;

L 2 is —O(CR a R b ) d — or —(NR c )(C═O) b —;

L 3 is a direct bond, —C≡C— or —(HC═CH) e (CR a R b ) d (NR c ) c —;

e is 0 or 1;

R 1 is hydrogen, hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro, N(R x ) 2 , SO 2 R x , Si(R x ) 3 or a ring which is: C 6-10 aryl, C 3-10 cycloalkyl, azetidinyl, a 5 or 6 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O, and S, not more than one heteroatom of which is O or S, a 6 membered heteroaromatic ring containing 1, 2 or 3 N atoms or a 7-15 membered unsaturated, partially saturated or saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; optionally substituted by one, two or three groups independently selected from L 4 -R d ;

R 2 is selected from hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1- alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro, N(R x ) 2 or a ring which is: C 6-10 aryl, C 3-10 cycloalkyl, azetidinyl, a 5 or 6 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S, a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms or a 7-15 membered unsaturated, partially saturated or saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of which rings being optionally substituted by one, two or three groups independently selected from R e ;

R 3 is selected from hydrogen, hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1- alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro, N(R x ) 2 or a ring which is: C 6-10 aryl, C 6-10 arylC 1-6 alkyl, C 3-10 cycloalkyl, azetidinyl, a 5 or 6 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S, a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms or a 7-15 membered unsaturated, partially saturated or saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of which rings being optionally substituted by one, two or three groups independently selected hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl and hydroxyC 1-6 alkyl;

R 4 is selected from hydrogen, hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1- alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro, N(R x ) 2 or a ring which is: C 6-10 aryl, C 6-10 arylC 1-6 alkyl, C 3-10 cycloalkyl, azetidinyl, a 5 or 6 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S, a 6 membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms or a 7-15 membered unsaturated, partially saturated or saturated heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of which rings being optionally substituted by one, two or three groups independently selected from L 5 -R f ;

R 5 is hydrogen, hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1- alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro or N(R x ) 2 ;

L 4 is a direct bond, —(CR a R b ) d (C═O) b (NR c ) c (C═O) b (O) g (CR a R b ) d (NR c ) c — or —(NR c ) c (SO 2 ) f (NR c ) c (CR a R b ) d ;

L 5 is a direct bond or —(C═O) b (NR c ) c (C═O) b (CR a R b ) d —;

f is 0 or 1;

g is 0 or 1;

each of R a and R b is independently hydrogen, hydroxy, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkoxy or haloC 1-6 alkoxy;

R c is hydrogen or C 1-6 alkyl;

R d is hydroxy, oxo, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1-6 alkoxy, amino, (C 1-6 alkyl)amino, di(C 1-6 alkyl)amino or a ring which is: C 6-10 aryl, C 3-10 cycloalkyl, azetidinyl, a 5, 6 or 7 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O, and S, not more than one heteroatom of which is O or S or a 6 membered heteroaromatic ring containing 1, 2 or 3 N atoms; any of which rings being optionally substituted by one, two or three groups independently selected from hydroxy, oxo, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1- alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro, amino, (C 1-6 alkyl)amino and di(C 1-6 alkyl)amino;

R e is hydroxy, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkoxycarbonyl, carboxy, or SO 2 R x ;

R f is hydroxy, oxo, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1-6 alkoxy or a ring which is: C 6-10 aryl, C 3-10 cycloalkyl, azetidinyl, a 5, 6 or 7 membered saturated or partially saturated heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a 5 membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O, and S, not more than one heteroatom of which is O or S or a 6 membered heteroaromatic ring containing 1, 2 or 3 N atoms; any of which rings being optionally substituted by one, two or three groups independently selected from hydroxy, oxo, cyano, halogen, C 1-6 alkyl, C 2-10 alkenyl, haloC 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxy, haloC 1- alkoxy, C 1-6 alkoxycarbonyl, carboxy, nitro, amino, (C 1-6 alkyl)amino and di(C 1-6 alkyl)amino;

each of R x and R y is independently hydrogen or C 1-6 alkyl;

or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof.

2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof in association with a pharmaceutically acceptable carrier.

3. A compound of claim 1 , or a pharmaceutically acceptable salt, stereoisomer, tautomer thereof and an anti-cancer agent for simultaneous, separate or sequential administration.

4. A compound of claim 1 , or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, for use in therapy.

5. A compound of claim 1 , or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, for use in the treatment of one or more conditions ameliorated by inhibition of one or more of the kinases selected from PDK1, FGFR3, NTRK3, RP-S6K, WEE1 and MARK.

6. A method of treating one or more conditions ameliorated by inhibition of one or more of the kinases selected from PDK1, FGFR3, NTRK3, RP-S6K, WEE1 and MARK, which method comprises administration to a patient in need thereof of an effective amount of a compound of claim 1 or a composition comprising a compound of claim 1 .

7. A compound which is selected from:

6-bromo-4-methoxypyrazolo[1,5-a]pyridine;

2-amino-6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile;

methyl 6-bromo-4-methoxy-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate;

3-iodo-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-Chloro-4-methoxy-6-(4-methyl-3-thienyl)pyrazolo[1,5-a]pyridine;

3-Chloro-4-methoxy-N-4-pyridinylpyrazolo[1,5-a]pyridin-6-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;

4-methoxy-6-phenylpyrazolo[1,5-a]pyridine-3-carbonitrile;

6-bromo-3-iodo-4-methoxypyrazolo[1,5-a]pyridine;

tert-Butyl ((2E)-3-(3-chloro-4-methoxypyrazolo[1,5-a]pyridine-6-yl)-2-propen-1-yl)carbamate;

(2E)-3-(3-Chloro-4-methoxypyrazolo[1,5-a]pyridine-6-yl)-2-propen-1-amine;

3-Chloro-6-ethyl-4-methoxypyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile;

3-bromo-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)-N-(2-furylmethyl)benzamide;

3-chloro-4-methoxy-6-[4-(morpholin-4-ylcarbonyl)phenyl]pyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-6-(6-morpholin-4-ylpyridin-3-yl)pyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]pyrazolo[1,5-a]pyridine;

5-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)-N,N-dimethylpyridin-2-amine;

3-chloro-6-(3-furyl)-4-methoxypyrazolo[1,5-a]pyridine;

N-[4-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)phenyl]morpholine-4-carboxamide;

3-chloro-4-methoxy-6-[4-(2-oxa-5-azabicyclo[2.2.1]hept-5-ylcarbonyl)phenyl]pyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-6-{4-[(4-methoxypiperidin-1-yl)carbonyl]phenyl}pyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-6-(4-pyridin-4-ylphenyl)pyrazolo[1,5-a]pyridine;

4-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)-N-phenylbenzamide;

4-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)-N-(2-methoxyethyl)benzamide;

5-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)pyridin-2-amine;

5-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)pyridin-2-ol;

3-iodo-4-methoxy-2-methyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-1-phenylpyrazolo[1,5-a]pyridin-6-amine;

3-chloro-4-methoxy-6-(4-morpholinyl)pyrazolo[1,5-a]pyridine;

3-chloro-6((E)-2-cyclopropylvinyl)-4-methoxypyrazolo[1,5-a]pyridine;

3-chloro-4-methoxy-6((1E)-3-methoxyvinyl)-4-methoxypyrazolo[1,5-a]pyridine;

3-chloro-6-(4-fluorobenzyl)-4-methoxypyrazolo[1,5-a]pyridine;

5-(2-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)ethyl)-2,2-dimethyl-1,3-dioxan-5-ol;

5-(3-chloro-4-methoxypyrazolo[1,5-a]pyridin-6-yl)pyrimidin-2-amine;

3-chloro-4-methoxy-6-(4-methyl-3-thienyl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(pyridin-3-ylethynyl)pyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{4-[3-(cyclopropylethynyl)-4-methoxypyrazolo[1,5-a]pyridin-6-yl]-1H-pyrazol-1-yl}-2-fluoropropan-1-ol;

4-methoxy-3-[(5-methyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(5-methyl-1-pyridin-2-yl-1H-pyrazol-4-yl)ethynyl]pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(3-methyl-1-pyridin-2-yl-1H-pyrazol-4-yl)ethynyl]pyrazolo[1,5-a]pyridine;

3-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(5-ethyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(5-cyclopropyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-{[5-methyl-1-(2-thienyl)-1H-pyrazol-4-yl]ethynyl}pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-{[1-methyl-2-(2-thienyl)-1H-imidazol-5-yl]ethynyl}pyrazolo[1,5-a]pyridine;

3-methoxy-N-(4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-yl)benzenesulfonamide;

N-(4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-yl)-N′-phenylurea;

pyridin-3-ylmethyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}azetidine-1-carboxylate;

6-bromo-3-(cyclopropylethynyl)-4-methoxypyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(trimethylsilyl)ethynyl]pyrazolo[1,5-a]pyridine;

3-ethynyl-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-[(4-methoxyphenyl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3,6-bis(cyclopropylethynyl)-4-methoxypyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-4-methoxy-6-phenylpyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-4-methoxy-6-(1H-pyrazol-5-yl)pyrazolo[1,5-a]pyridine;

3-(4-methoxy-6-phenylpyrazolo[1,5-a]pyridine-3-yl)prop-2-yn-1-ol;

3-(4-methoxy-6-phenylpyrazolo[1,5-a]pyridine-3-yl)prop-2-ynamide;

4-methoxy-3-[(4-methoxyphenyl)ethynyl]-6-phenylpyrazolo[1,5-a]pyridine;

4-methoxy-6-phenyl-3-(pyridine-3-ylethynyl)pyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-4-methoxy-6-pyridin-4-ylpyrazolo[1,5-a]pyridine;

4-methoxy-3-[(1-methyl-1H-imidazol-5-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

N-(3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}phenyl)acetamide;

3-(cyclopropylethynyl)-4-methoxy-6-pyridin-3-ylpyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-4-methoxy-6-pyrimidin-5-ylpyrazolo[1,5-a]pyridine;

N-{4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]but-3-yn-1-yl}methanesulfonamide;

tert-butyl 3-{3-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]prop-2-yn-1-yl}pyrrolidine-1-carboxylate;

tert-butyl 2-{3-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]prop-2-yn-1-yl}pyrrolidine-1-carboxylate;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(pyridine-4-ylethynyl)pyrazolo[1,5-a]pyridine;

5-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}pyridine-2-amine;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}pyridine-2-amine;

tert-butyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}azetidine-1-carboxylate;

tert-butyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}pyrrolidine-1-carboxylate;

tert-butyl 4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}piperidine-1-carboxylate;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(6-pyrrolidin-1-ylpyridin-3-yl)ethynyl]pyrazolo[1,5-a]pyridine;

1-(3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}phenyl)ethanone;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}phenol;

3-[(3,5-dimethyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(3,5-dimethylisoxazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}-N,N-dimethyl-1H-imidazole-1-sulfonamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(1-methyl-1H-pyrazol-4-yl)ethynyl]pyrazolo[1,5-a]pyridine;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}pyridine-2-carboxamide;

4-methoxy-3-[(6-methoxypyridin-3-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

5-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}pyridine-2-ol;

3-[(2-chloropyridin-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-[(1-methyl-1H-imidazol-4-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(6-fluoropyridin-3-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

5-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-yl]ethynyl}-1,3-thiazol-2-amine;

N-(4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-yl)acetamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(1,3-thiazol-2-ylethynyl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-[(5-methylisoxazol-4-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-(1H-imidazol-4-ylethynyl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(1,3,5-trimethyl-1H-pyrazol-4-yl)ethynyl]pyrazolo[1,5-a]pyridine;

tert-butyl 4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1H-pyrazole-1-carboxylate;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-ylethynyl)pyrazolo[1,5-a]pyridine;

3-[(1-benzyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-(azetidin-3-ylethynyl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-[(2-methyl-1H-imidazol-4-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(pyrrolidin-3-ylethynyl)pyrazolo[1,5-a]pyridine;

methyl 4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1H-pyrrole-2-carboxylate;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}imidazo[1,2-a]pyridine;

3,3′-buta-1,3-diyne-1,4-diylbis[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine];

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1-methyl-1H-pyrazol-3-amine;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}imidazo[1,2-a]pyrazine;

3-[(5-tert-butyl-1,3,4-thiadiazol-2-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)ethynyl]pyrazolo[1,5-a]pyridine;

3-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine;

3-[(5-ethyl-1,3,4-thiadiazol-2-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

tert-butyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate;

N-(5-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1,3-thiazol-2-yl)acetamide;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-6-methylimidazo[1,2-a]pyridine;

4-methoxy-3-[(1-methyl-2-phenyl-1H-imidazol-5-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(2-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(4-chlorophenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-7-methylimidazo[1,2-a]pyridine;

3-{[1-(4-tert-butylphenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(2-chlorophenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-8-methylimidazo[1,2-a]pyridine;

3-[(1,2-dimethyl-1H-imidazol-5-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(1-phenyl-1H-pyrazol-4-yl)ethynyl]pyrazolo[1,5-a]pyridine;

3-[(1,5-dimethyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[5-methyl-1-(3-methylphenyl)-1H-pyrazol-4-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[1-(3-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(5-methyl-1-pyridin-3-yl-1H-pyrazol-4-yl)ethynyl]pyrazolo[1,5-a]pyridine;

3-{[1-(3-chlorophenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(3-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[1-(2-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(4,5-dimethyl-1,3-thiazol-2-yl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(2,6-dimethylphenyl)-5-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(2-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-[(3-methyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(5-tert-butyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(5-isopropyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(5-cyclobutyl-1-phenyl-1H-pyrazol-4-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-{[5-methyl-1-(3-thienyl)-1H-pyrazol-4-yl]ethynyl}pyrazolo[1,5-a]pyridine;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1′,5-dimethyl-1′H-1,4′-bipyrazole;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(3-pyrrolidin-3-ylprop-1-yn-1-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(5-pyridin-3-yl-1,3,4-thiadiazol-2-yl)ethynyl]pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-{[1-methyl-2-(3-thienyl)-1H-imidazol-5-yl]ethynyl}pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[2-(2-methoxyethyl)-1-methyl-1H-imidazol-5-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(2-isopropyl-1-methyl-1H-imidazol-5-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(2-cyclobutyl-1-methyl-1H-imidazol-5-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-{[1-methyl-2-(tetrahydrofuran-3-yl)-1H-imidazol-5-yl]ethynyl}pyrazolo[1,5-a]pyridine;

3-{[2-(3-furyl)-1-methyl-1H-imidazol-5-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[(2-cyclopentyl-1-methyl-1H-imidazol-5-yl)ethynyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[2-(fluoromethyl)-1-methyl-1H-imidazol-5-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[1-methyl-2-(5-methylisoxazol-3-yl)-1H-imidazol-5-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{[2-(2-furyl)-1-methyl-1H-imidazol-5-yl]ethynyl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[(1-methyl-2-pyridin-2-yl-1H-imidazol-5-yl)ethynyl]pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[1-methyl-2-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-3-{[1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1H-imidazol-5-yl]ethynyl}-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

methyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}azetidine-1-carboxylate;

benzyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}azetidine-1-carboxylate;

pyridin-2-ylmethyl 3-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}azetidine-1-carboxylate;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1,5-naphthyridine;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}-1,8-naphthyridine;

4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}quinazoline;

N-(4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-yl)-2-methylbenzenesulfonamide;

N-(4-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethynyl}pyridin-2-yl)benzenesulfonamide;

3-(2,7-diazaspiro[3.5]non-2-ylmethyl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}pyridin-3-amine;

3-(2,6-diazaspiro[3.3]hept-2-ylmethyl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-2-pyrrolidin-1-ylethanamine;

2-(1H-imidazol-4-yl)-N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}ethanamine;

1-cyclopropyl-N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}methanamine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-2-(1,3-thiazol-2-yl)ethanamine;

2-({[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}amino)-6-methylbenzoic acid;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-3-(trifluoromethyl)pyridin-4-amine;

3-bromo-N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}pyridin-4-amine;

5-({[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}amino)pyridine-2-carbonitrile;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-1,3,5-trimethyl-1H-pyrazol-4-amine;

2-chloro-N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}pyridin-4-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}imidazo[1,2-a]pyridin-3-amine;

N-[3-({[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}amino)phenyl]acetamide;

5-({[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}amino)pyridin-2-ol;

6-methoxy-N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo yl]methyl}pyridin-3-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}pyrazin-2-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}pyridazin-3-amine;

3-({[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}amino)pyridin-2-ol;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}benzene-1,4-diamine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-1H-indazol-5-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-1H-benzimidazol-5-amine;

5-({[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}amino)-1,3-dihydro-2H-benzimidazol-2-one;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-1H-indol-6-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-4-methylpyridin-3-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-2-methylpyridin-3-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}pyrimidin-5-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-6-methylpyridin-3-amine;

N-{[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}-1,2,3-thiadiazol-5-amine;

N-benzyl-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-morpholin-4-ylpyrazolo[1,5-a]pyridine;

3-(2,7-diazaspiro[3.5]non-2-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-(2,6-diazaspiro[3.5]non-2-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(2-pyridin-2-ylethyl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(2-pyridin-3-ylethyl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(2-pyridin-4-ylethyl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(pyridin-2-ylmethyl)pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-pyridin-3-ylpyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-[(1-methyl-1H-pyrazol-4-yl)methyl]pyrazolo[1,5-a]pyridin-3-amine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-pyridin-4-ylpyrazolo[1,5-a]pyridin-3-amine;

N′-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-N,N-dimethylpropane-1,3-diamine;

3-(5-bromo-1-benzothien-2-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-{1-[2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-1H-1,2,3-triazol-4-yl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-Methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(1H-pyrazol-4-yl)-pyrazolo[1,5-a]pyridine;

4-Methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(1-pyridin-2-ylmethyl-1H-pyrazol-4-yl)-pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-[1-(2-morpholin-4-ylethyl)-1H-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyridine;

3-{1-[2-(3,5-dimethylisoxazol-4-yl)ethyl]-1H-1,2,3-triazol-4-yl}-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-[1-(2-fluoropyridin-3-yl)-1H-1,2,3-triazol-4-yl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]benzonitrile;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(4-pyridin-4-ylphenyl)pyrazolo[1,5-a]pyridine;

5-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-1H-indazole;

N-{4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]benzyl}acetamide;

N-benzyl-4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]benzamide;

4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]benzamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(4-pyridin-2-ylphenyl)pyrazolo[1,5-a]pyridine;

N-(2-furylmethyl)-4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]benzamide;

1-ethyl-3-{2-methoxy-4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]phenyl}urea;

2-fluoro-4-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-N-phenylbenzamide;

N-benzyl-2-methoxy-5-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(4-pyridin-3-ylphenyl)pyrazolo[1,5-a]pyridine;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-pyridin-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-(2,3-dimethylpyridin-4-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-[4-(acetylamino)phenyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-[2-(1,3-thiazol-2-yl)ethyl]pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-N-methyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-(cyclopropylmethyl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-[3-(dimethylamino)propyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(pyridin-2-ylmethyl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(2-pyridin-2-ylethyl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-(2-pyridin-4-ylethyl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-pyridin-3-ylpyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-N-[3-(trifluoromethyl)pyridin-4-yl]pyrazolo[1,5-a]pyridine-3-carboxamide;

N-(1-benzylpyrrolidin-3-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-[1-(hydroxymethyl)cyclopentyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-[5-(ethylsulfonyl)-2-hydroxyphenyl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-(4-aminopyridin-2-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-N-(6-methoxyquinolin-4-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-methoxy-N,6-bis(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-imidazo[1,2-a]pyridin-3-yl-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

N-[5-(aminocarbonyl)-1-ethyl-1H-pyrazol-4-yl]-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide;

4-(benzyloxy)-3-bromo-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

3-bromo-6-(1-methyl-1H-pyrazol-4-yl)-4-(piperidin-3-ylmethoxy)pyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-6-(1-methyl-1H-pyrazol-4-yl)-4-(pyridin-3-ylmethoxy)pyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-6-(1-methyl-1H-pyrazol-4-yl)-4-(pyridin-2-ylmethoxy)pyrazolo[1,5-a]pyridine;

tert-butyl 3-({[3-bromo-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy}methyl)piperidine-1-carboxylate;

6-(1-methyl-1H-pyrazol-4-yl)-4-(pyridin-2-ylmethoxy)pyrazolo[1,5-a]pyridine;

4-(benzyloxy)-3-(cyclopropylethynyl)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

6-(1-methyl-1H-pyrazol-4-yl)-4-(pyridin-4-ylmethoxy)pyrazolo[1,5-a]pyridine;

3-(cyclopropylethynyl)-6-(1-methyl-1H-pyrazol-4-yl)-4-(pyridin-4-ylmethoxy)pyrazolo[1,5-a]pyridine;

tert-butyl 3-({[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy}methyl)piperidine-1-carboxylate;

3-bromo-6-(1-methyl-1H-pyrazol-4-yl)-4-{[1-(methylsulfonyl)piperidin-3-yl]methoxy}pyrazolo[1,5-a]pyridine;

3-[(1-methyl-1H-imidazol-5-yl)ethynyl]-6-(1-methyl-1H-pyrazol-4-yl)-4-(pyridin-3-ylmethoxy)pyrazolo[1,5-a]pyridine;

tert-butyl [6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]carbamate;

4-{2-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]ethyl}pyridin-2-amine;

1-[4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-2-[1-(trifluoroacetyl)azetidin-3-yl]ethanone;

3-ethyl-4-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine;

5-(benzyloxy)-7-phenylimidazo[1,2-a]pyridine;

5-(benzyloxy)-3-iodo-7-phenylimidazo[1,2-a]pyridine;

3-iodo-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-(pyridin-3-ylethynyl)imidazo[1,2-a]pyridine;

3-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)prop-2-ynamide;

3-(cyclopropylethynyl)-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

3-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)prop-2-yn-1-amine;

3-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)prop-2-yn-1-ol;

5-(benzyloxy)-3-(cyclopropylethynyl)-7-phenylimidazo[1,2-a]pyridine;

3-(cyclopropylethynyl)-5-methoxy-7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine;

3-(3-cyclopentylprop-1-yn-1-yl)-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

(2S)-4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)but-3-yn-2-ol;

(2R)-4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)but-3-yn-2-ol;

5-methoxy-3-[(4-methoxyphenyl)ethynyl]-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-{[4-(trifluoromethyl)phenyl]ethynyl}imidazo[1,2-a]pyridine;

3-[(4-chlorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-(3-thienylethynyl)imidazo[1,2-a]pyridine;

4-[(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)ethynyl]benzonitrile;

3-[(4-fluorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-(phenylethynyl)imidazo[1,2-a]pyridine;

5-methoxy-3-[(2-methylphenyl)ethynyl]-7-phenylimidazo[1,2-a]pyridine;

3-[(2-chlorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

3-[(2-fluorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

3-[(3-chlorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

3-[(3-fluorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-3-[(3-methylphenyl)ethynyl]-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-(pyridin-2-ylethynyl)imidazo[1,2-a]pyridine;

5-methoxy-3-[(1-methyl-1H-imidazol-5-yl)ethynyl]-7-phenylimidazo[1,2-a]pyridine;

(1R)-3-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)-1-phenylprop-2-yn-1-ol;

(1S)-3-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)-1-phenylprop-2-yn-1-ol;

5-methoxy-7-phenyl-3-(2-thienylethynyl)imidazo[1,2-a]pyridine;

5-methoxy-3-[(2-methoxyphenyl)ethynyl]-7-phenylimidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-(pyridin-4-ylethynyl)imidazo[1,2-a]pyridine;

3-[(2,4-difluorophenyl)ethynyl]-5-methoxy-7-phenylimidazo[1,2-a]pyridine;

1-[3-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)prop-2-yn-1-yl]urea;

3-[(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)ethynyl]aniline;

N-{3-[(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)ethynyl]phenyl}methanesulfonamide;

N-[(1S,2R)-2-aminocyclohexyl]-4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide;

methyl 4-[5-(benzyloxy)-7-phenylimidazo[1,2-a]pyridin-3-yl]benzoate;

methyl 4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)benzoate;

5-methoxy-7-phenyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine;

5-methoxy-3-(1-methyl-1H-pyrazol-4-yl)-7-phenylimidazo[1,2-a]pyridine;

4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)benzamide;

5-methoxy-7-phenyl-3-(3-thienyl)imidazo[1,2-a]pyridine;

5-methoxy-7-phenyl-3-(2-thienyl)imidazo[1,2-a]pyridine;

2-[4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)-1H-pyrazol-1-yl]acetamide;

methyl 4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxylate;

4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxylic acid;

N-[(1S,2R)-2-aminocyclohexyl]-4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide;

4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide;

5-methoxy-7-phenyl-3-(1H-pyrrol-3-yl)imidazo[1,2-a]pyridine;

4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide;

N-[(1S,2S)-2-aminocyclohexyl]-4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide;

N-(2-aminoethyl)-4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide;

5-methoxy-7-phenyl-3-[5-(piperazin-1-ylcarbonyl)-3-thienyl]imidazo[1,2-a]pyridine;

4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)-N-[3-(2-oxopyrrolidin-1-yl)propyl]thiophene-2-carboxamide;

3-isothiazol-4-yl-5-methoxy-7-phenylimidazo[1,2-a]pyridine; or

4-(5-methoxy-7-phenylimidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2-carboxamide;

and pharmaceutically acceptable salts, stereoisomers and tautomers thereof.