IP Library › Granted Patent US 8,637,466
Granted Patent B2
US 8,637,466 · App. 13/058,320 · Granted Jan 28, 2014

Multi-arm polymeric alkanoate conjugates

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Quick Facts
Patent No.
US 8,637,466
App. No.
13/058,320
Granted
Jan 28, 2014
Kind
B2
Abstract

Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.

Claims (3)

1. A multi-armed polymer conjugate having the structure:

where n ranges from about 40 to about 300.

2. The multi-armed polymer conjugate of claim 1 , wherein the weight average molecular weight of the conjugate is about 20,000 daltons.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 28571, FRAME 0141 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036866/0700 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
GRANT OF SECURITY INTEREST Recorded Jul 17, 2012
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 028571/0141 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 25, 2011
From: KOZLOWSKI, ANTONI; MCMANUS, SAMUEL P.; RIGGS-SAUTHIER, JENNIFER; SHEN, XIAOMING; ZHANG, WEN
To: NEKTAR THERAPEUTICS
Reel/Frame 026338/0530 →