POLYMER FOR FILLER FOR PREPROCESSING COLUMN
It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column. The present invention relates to a polymer obtained by introducing an anion exchanging group to a glycidyl group in a polymer obtained by polymerizing the compound represented by the following general formula [1]: and the compound represented by the following general formula [2]: a filler (column) for measuring an acidic group binding perfluoro compound at terminal which comprises said polymer; a method for measuring said perfluoro compound by using said column; a filler (column) for measuring a drug which comprises the above-described polymer; and a method for measuring a drug by using said column.
1 . A polymer obtained by introducing an anion exchanging group to a glycidyl group of a polymer obtained by polymerizing a compound represented by the following general formula [1]:
(wherein each of R 1 and R 2 independently represents a hydrogen atom, a linear alkyl group having 1 to 3 carbon atoms or a halogen atom, Bz represents benzene ring), and a compound represented by the following general formula [2]:
(wherein R 9 represents a hydrogen atom, a linear alkyl group having 1 to 3 carbon atoms or a halogen atom, R 10 represents a linear alkylene group having 1 to 3 carbon atoms, each of R 11 and R 12 independently represents a hydrogen atom or a linear alkyl group having 1 to 6 carbon atoms).
2 . The polymer according to claim 1 , wherein the anion exchanging group is a tertiary amino group.
3 . The polymer according to claim 1 , wherein the anion exchanging group is a morpholino group or a diethylamino group.
4 . The polymer according to claim 1 , wherein the compound represented by the general formula [1] is divinylbenzene.
5 . The polymer according to claim 1 , wherein the compound represented by the general formula [2] is the compound represented by the following general formula [2′]:
6 . A filler for measuring a perfluoro compound having an acidic group at terminal, comprising the polymer according to claim 1 .
7 . The filler according to claim 6 , wherein the acidic group at terminal of the perfluoro compound is a carboxyl group or a sulfo group.
8 . A preprocessing column for measuring a perfluoro compound having the acidic group at terminal which is filled with the filler according to claim 6 .
9 . A measuring method for measuring a perfluoro compound having an acidic group at terminal, characterized in using the column according to claim 8 .
10 . A measuring method for a perfluoro compound comprising a step for adsorbing said perfluoro compound by passing the sample containing said perfluoro compound having an acidic group at terminal to the column according to claim 8 ; a step for eluting said perfluoro compound by eluate; and a step for measuring the obtained perfluoro compound.
11 . The polymer according to claim 1 , wherein the anion exchanging group is an ammonium group represented by the following general formula [3]:
(wherein each of R 3 represents independently a linear alkyl group having 1 to 3 carbon atoms, R 4 represents a linear alkyl group having 1 to 6 carbon atoms).
12 . The polymer according to claim 11 , wherein R 3 represents a methyl group and R 4 represents an ethyl group in the general formula [3].
13 . The polymer according to claim 11 , wherein said polymer is obtained by introducing the ammonium group represented by the general formula [3] to the glycidyl group in the polymer obtained by polymerizing monomers containing the compound represented by the general formula [1] and the compound represented by the general formula [2] and further the compound represented by the following general formula [4]:
(wherein each of three R 15 represents independently a linear alkylene group having 1 to 3 carbon atoms, each of three R 16 independently represents a hydrogen atom, a linear alkyl group having 1 to 3 carbon atoms or a halogen atom).
14 . The polymer according to claim 13 , wherein R 15 in the general formula [4] is a methylene group and R 16 is a hydrogen atom.
15 . The polymer according to claim 11 , wherein the compound represented by the general formula [1] is divinylbenzene.
16 . The polymer according to claim 11 , wherein the compound represented by the general formula [2] is the compound represented by the following general formula [2′]:
17 . A filler for measuring drugs which comprises the polymer according to claim 11 .
18 . A preprocessing column filled with the filler according to claim 17 .
19 . A measuring method of a drug characterized in using the column according to claim 18 .
20 . A measuring method of a drug comprising a step for adsorbing said drug by passing the sample containing said drug to the column according to claim 18 ; a step for eluting said drug by eluate; and a step for measuring the eluted drug.