Melanoma antigen peptide and uses thereof
View Patent ↗The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.
1. A melanoma antigen peptide having an amino acid sequence that is less than 50 amino acids in length and comprising SEQ ID NO:2:
TX 2 NDECWPX 9
(SEQ ID NO: 2)
wherein X 2 is leucine, methionine, valine, isoleucine or glutamine and X 9 is alanine, valine or leucine.
2. A melanoma antigen peptide according to claim 1 , wherein said melanoma antigen peptide is MELOE-1 having the sequence SEQ ID NO: 4.
3. A melanoma antigen peptide according to claim 1 , wherein said melanoma antigen peptide is selected in the group consisting of peptides having the sequence SEQ ID NO: 6 to SEQ ID NO: 20.
4. A MHC/peptide multimer comprising a melanoma antigen peptide according to claim 3 .
5. An immunising composition comprising
at least one melanoma antigen peptide according to claim 1 .