Methods of treatment using single doses of oritavancin
View Patent ↗Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against a wide range of bacteria. Methods for the treatment, prophylaxis and prevention of bacterial infection and disease in animals, including humans, using a single dose of oritavancin over the course of therapy, are described.
1. A method of treating a complicated skin and skin structure infection (cSSSI) in a subject, comprising administering a single dose of a therapeutically effective amount of a pharmaceutical composition comprising oritavancin, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent, over a course of therapy to a subject having cSSSI, wherein the single dose comprises at least 1200 mg oritavancin, or a pharmaceutically acceptable salt thereof, thereby treating cSSSI in the subject.
2. The method of claim 1 , wherein the single dose comprises between 1200 mg to 1800 mg oritavancin, or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein said administering is via intravenous administration or oral administration.
4. The method of claim 1 , wherein the bacteria causing cSSSI a is one or more bacteria selected from the group consisting of a gram-positive bacteria, Staphylococcus aureus , methicillin-resistant Staphylococcus aureus , vancomycin-resistant Staphylococcus aureus , vancomycin-intermediate Staphylococcus aureus , vancomycin hetero-intermediate Staphylococcus aureus, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus, Streptococcus intermedius, Streptococcus constellatus, Streptococcus dysgalactiae, Streptococcus dysgalactiae subsp. equisimilis, Enterococcus faecalis , vancomycin-resistant Enterococcus faecalis, Enterococcus faecium , and vancomycin-resistant Enterococcus faecium.