ELASTOMERIC ARTICLE HAVING A BROAD SPECTRUM ANTIMICROBIAL AGENT AND METHOD OF MAKING
A method for impregnating a polymer with a bioactive material includes preparing a bioactive metal solution having a bioactive metal, a first solvent in which the bioactive metal is insoluble and a second solvent in which the bioactive metal is slightly soluble. The method also includes soaking the polymer in the bioactive metal solution. Another method for impregnating a polymer with a bioactive material includes soaking the polymer in a swelling solvent followed by soaking the polymer in a bioactive metal solution having the bioactive metal and a solvent in which the bioactive metal is slightly soluble. A bioactive metal-impregnated polymer is prepared by soaking a polymer in a saturated bioactive metal solution comprising a bioactive metal, a swelling solvent in which the bioactive metal is insoluble, and a second solvent in which the bioactive metal is slightly soluble.
1 . A method for impregnating a polymer with a bioactive metal at a concentration between about 0.10% and about 15% by weight, the method comprising:
preparing a bioactive metal solution comprising:
a bioactive metal;
a first solvent in which the bioactive metal is insoluble; and
a second solvent in which the bioactive metal is slightly soluble; and
soaking the polymer in the bioactive metal solution.
2 . The method of claim 1 , wherein the bioactive metal is a source of silver (I) ions.
3 . The method of claim 2 , wherein the bioactive metal is selected from the group consisting of silver nitrate, silver sulfadiazine, silver sulfathiazole, silver chloride and combinations thereof.
4 . The method of claim 1 , wherein the polymer is polyisoprene.
5 . The method of claim 1 , wherein the bioactive metal solution contains between about 0.005 and about 0.5 grams of bioactive metal for every 1 gram of polymer.
6 . The method of claim 5 , wherein the polymer is impregnated with a targeted amount of the bioactive metal after the polymer is soaked in the bioactive metal solution for between about 10 minutes and about 3 hours.
7 . The method of claim 1 , further comprising:
soaking the polymer in an antimicrobial solution.
8 . The method of claim 7 , wherein a component of the antimicrobial solution is selected from the group consisting of rifampin, clindamycin, minocycline, chlorhexidine, sulfadiazine, erythromycin, norfloxacin, tobramycin, miconazole, quaternary ammonium salts and combinations thereof.
9 . The method of claim 7 , wherein the polymer is soaked in the bioactive metal solution and the antimicrobial solution at the same time.
10 . A method for rapidly impregnating a polymer with between about 0.10% and about 15% of a bioactive metal by weight, the method comprising:
preparing a bioactive metal solution comprising:
the bioactive metal;
a solvent mixture in which the bioactive metal is slightly soluble; and
soaking the polymer in the bioactive metal solution, for between about 10 minutes and about 3 hours.
11 . A method for rapidly impregnating a polymer with between about 0.10% and about 15% of a bioactive metal by weight, the method comprising:
soaking the polymer in a swelling solvent for between about 5 minutes and about 1 hour;
soaking the polymer in a bioactive metal solution comprising:
the bioactive metal; and
a solvent in which the bioactive metal is slightly soluble.
12 . The method of claim 11 wherein the polymer is polyisoprene and wherein the bioactive metal is selected from the group consisting of silver nitrate, silver sulfadiazine, silver sulfathiazole, silver chloride and combinations thereof.
13 . The method of claim 11 , wherein the solvent of the bioactive metal solution is the same as the swelling solvent.
14 . The method of claim 11 , further comprising soaking the swellable polymer in an antimicrobial solution containing a component selected from the group consisting of rifampin, clindamycin, minocycline, chlorhexidine, sulfadiazine, erythromycin, norfloxacin, tobramycin, miconazole, quaternary ammonium salts and combinations thereof.
15 . The method of claim 14 , wherein the swellable polymer is soaked in the saturated silver salt solution and the antimicrobial solution at the same time.
16 . A bioactive metal-impregnated polymer, wherein a polymer is soaked in a saturated bioactive metal solution comprising a bioactive metal, a swelling solvent in which the bioactive metal is insoluble, and a second solvent in which the bioactive metal is slightly soluble.
17 . The bioactive metal-impregnated polymer of claim 16 , wherein the bioactive metal is selected from the group consisting of silver nitrate, silver sulfadiazine, silver sulfathiazole, silver chloride and combinations thereof.
18 . The bioactive metal-impregnated polymer of claim 16 , wherein the polymer is polyisoprene.
19 . The bioactive metal-impregnated polymer of claim 16 , wherein the bioactive metal solution contains between about 0.005 and about 0.5 grams of bioactive metal for every 1 gram of polymer.
20 . The bioactive metal-impregnated polymer of claim 16 , further comprising:
an antimicrobial agent selected from the group consisting of rifampin, clindamycin, minocycline, chlorhexidine, sulfadiazine, erythromycin, norfloxacin, tobramycin, miconazole, quaternary ammonium salts and combinations thereof.