Process for preparing snuff composition
A method for the preparation of a nicotine-cellulose combination, the method comprising simultaneous loading of the nicotine on the cellulose and agglomeration of the particles so as to obtain a suitably loaded combination with a mean particle size that is suitable for use e.g. in snuff compositions packed in pouches of gauze or other materials with opening. The invention further relates to the use of such a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.
1. A method for the preparation of a nicotine-cellulose combination, the method comprising
i) dissolving a nicotine in an alcohol to form a nicotine solution, and
ii) mixing the nicotine solution with a cellulose having a mean particle size of less than about 180 μm in a high-shear mixer for at the most 1 hour/kg cellulose employed under conditions suitable to simultaneously load the nicotine into voids or pores of the cellulose and agglomerate the particles to obtain a nicotine-cellulose combination having a mean particle size of from about 200 μm to about 500 μm and with a load of nicotine of at least 5% v/v.
2. A method according to claim 1 , wherein the temperature in the mixer is at the most about 30-40° C.
3. A method according to claim 1 , wherein at the most 10% of the nicotine-cellulose combination obtained has a particle size of 200 μm or less.
4. A method according to claim 1 , further comprising drying the mixture resulting from step ii) by means of vacuum drying at the most at room temperature.
5. A method according to claim 1 , wherein the alcohol is ethanol in a concentration of at least 98%.
6. A method according to claim 5 , wherein the ethanol is in a concentration of at least 99%.
7. A method according to claim 3 , wherein at the most 5% of the nicotine-cellulose combination obtained has a particle size of 200 μm or less.