Ophthalmic compositions with biguanide and PEG-glycerol esters

1. An ophthalmic composition comprising:

0.5 ppm to 1.3 ppm of poly(hexamethylene biguanide); and

0.01 wt. % to 0.3 wt. % of glycereth-18-ethylhexanoate.

2. The composition of claim 1 further comprising hyaluronic acid present from 0.005 wt. % to 0.1 wt. %.

3. The composition of claim 1 further comprising

α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl) ammonium chloride, which is present from

0.5 ppm to 3 ppm.

4. The composition of claim 1 further comprising 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula II

wherein R 1 is R or —(CH 2 ) n —NHC(O)R, wherein R is a C 8 -C 10 alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R 2 and R 3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R 4 is a C 2 -C 8 alkylene optionally substituted with hydroxyl.

5. The composition of claim 4 wherein the surfactant of general formula II is where R 1 is R; R 2 and R 3 are each methyl; and R 4 is a C 2 -C 4 alkylene.

6. The composition of claim 1 further comprising dexpanthenol, sorbitol, glycolic acid, 2-amino-2-methyl-1,3-propanediol or any mixture thereof.

7. The composition of claim 1 further comprising propylene glycol, hydroxypropyl guar or myristamidopropyl dimethylamine.

8. The composition of claim 1 further comprising hydroxypropylmethyl cellulose.

9. An aqueous contact lens care solution composition comprising:

0.8 ppm to 1.3 ppm of poly(hexamethylene biguanide);

0.5 ppm to 2 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride; and

0.01 wt. % to 0.2 wt. % of glycereth-18-ethylhexanoate.

10. The contact lens care solution of claim 9 further comprising a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof.

11. A method of cleaning and disinfecting a contact lens, the method comprising soaking the contact lens in an aqueous solution for at least two hours, the solution comprising:

0.8 ppm to 1.3 ppm of poly(hexamethylene biguanide); and

0.01 wt. % to 0.2 wt. % of glycereth-18-ethylhexanoate.

12. The method of claim 11 further comprising inserting the cleaned and disinfected contact lens into the eye without rinsing the lens after soaking.

13. The method of claim 11 wherein the solution further comprises 0.5 ppm to 2 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride.