Crosslinked silane coating for medical devices
View Patent ↗Coatings are provided in which surfaces may be activated by covalently bonding a combination of silane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
1. A composition comprising crosslinked silane derivatives linked to a surface of a medical device having at least two functional terminals comprising an epoxide group and a sulfhydryl group.
2. The composition of claim 1 wherein the sulfhydral group comprises 2%-20% of the functional terminals.
3. The composition of claim 1 wherein the surface comprises a metal.
4. The composition of claim 3 wherein the surface is selected from a group comprising stainless steel, cobalt alloys, cobalt chromium alloys, and nitinol alloys.
5. The composition of claim 1 wherein the surface comprises a glass.
6. The composition of claim 1 wherein the medical device is a stent.
7. The composition of claim 1 wherein the sulfhydryl group is oxidized to form sulfonic acid which serves as an in situ catalyst for ring opening polymerization of lactone monomers and dimers to form a first polymer layer.
8. A composition for coating a surface prepared by a method comprising the steps of: activating the surface of a medical device to create a linkage; applying a silane derivative having a sulfhydryl group and a epoxide group to the activated surface; and
oxidizing the sulfhydrl group to form sulfonic acid.
9. The composition prepared by the method of claim 8 further comprising the step of converting the epoxide group to a difunctional initiator.
10. The composition prepared by the method of claim 9 wherein the epoxide group is converted to a difunctional group by reacting the epoxide group with a diol or a diamine
11. The composition prepared by the method of claim 10 further comprising the step of introducing a lactone dimer.
12. The composition prepared by the method of claim 10 further comprising the step of introducing a lactone monomer.
13. The composition prepared by the method of claim 10 further comprising the step of introducing a combination of lactone monomers and dimers.
14. The composition prepared by the method of claim 8 wherein the surface is metallic.
15. The composition prepared by the method of claim 8 wherein the surface is a silicon based surface.
16. The composition prepared by the method of claim 11 wherein the lactone dimer is selected from a group comprising a lactide, a glycolide, and a dioxane.
17. The composition prepared by the method of claim 12 wherein the lactone monomer is selected from a group comprising a phosphate cyclic monomer and caprolactone.