Phospholipid copolymers
View Patent ↗The present disclosure provides copolymers including a first monomer including at least one phospholipid possessing at least one hydroxyl group and a second monomer including a cyclic monomer. Compositions, medical devices, and coatings including such copolymers are also provided.
1. A copolymer comprising:
at least one phospholipid possessing at least one hydroxyl group of the following formula:
wherein R 1 is an alcohol possessing at least one hydroxyl group, R 3 is an alkyl group having from about 1 carbon atom to about 10 carbon atoms, w is a number from about 1 to about 10, x is a number from about 250 to about 750, y is a number from about 1 to about 10, and z is a number from about 250 to about 750, and
at least one cyclic monomer.
2. The copolymer of claim 1 , wherein the at least one cyclic monomer is selected from the group consisting of trimethylene carbonate, caprolactone, valerolactone, 1,4-dioxane-2-one, 1,5-dioxepan-2-one, glycolide, lactide, and combinations thereof.
3. The copolymer of claim 1 , wherein the copolymer possesses the phospholipid in an amount from about 5 percent by weight to about 95 percent by weight of the copolymer, and the cyclic monomer in an amount from about 5 percent by weight to about 95 percent by weight of the copolymer.
4. The copolymer of claim 1 , further comprising at least one additional monomer selected from the group consisting of polyethylene glycol, polypropylene glycol, polyethylene glycol-polypropylene glycol copolymers, vinyl monomers, silicones, and combinations thereof.
5. A medical device comprising the copolymer of claim 1 .
6. The medical device of claim 5 , wherein the copolymer comprises a coating on at least a portion of the medical device.
7. The medical device of claim 5 , wherein the medical device is selected from the group consisting of sutures, surgical meshes, anti-adhesion devices, contact lenses, intraocular lenses, staples, clips, buttresses, lapbands, catheters, bandages, stents, grafts, stent/grafts, knotless wound closures, sealants, adhesives, tissue scaffolds, pins, screws, orthopedic hardware, spacers, and pacemakers.