Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy
View Patent ↗This invention relates to the use of the phytocannabinoid cannabidivarin (CBDV) and combinations of the phytocannabinoid CBDV with tetrahydrocannabivarin (THCV) and cannabidiol (CBD) in the treatment of epilepsy. The invention further relates to the use of the phytocannabinoid CBDV in combination with standard anti-epileptic drugs (SAEDs). Preferably the SAED is one of ethosuximide, valproate or phenobarbital.
1. A method for the treatment of epileptic seizures, which comprises administering to a subject in need thereof a therapeutically effective amount of pure cannabidivarin (CBDV) as the only active cannabinoid.
2. The method of claim 1 , wherein the type of epileptic seizure to be treated is a generalised seizure or a temporal lobe seizure.
3. The method of claim 1 , wherein the CBDV is synthetic CBDV.
4. The method of claim 1 , wherein the CBDV is in an isolated form.
5. The method of claim 1 , wherein the CBDV is used in combination with a standard anti-epileptic drug.
6. The method of claim 5 , wherein the standard anti-epileptic drug has a mechanism of action which acts via sodium or calcium channels, or enhances GABAergic inhibition.
7. The method of claim 6 , wherein the standard anti-epileptic drug that enhances GABAergic inhibition is phenobarbital.
8. The method of claim 6 , wherein the standard anti-epileptic drug having a mechanism of action which acts via sodium or calcium channels either:
modifies low-threshold or transient neuronal calcium currents; or
reduces high-frequency neuronal firing and sodium-dependent action potentials and may additionally enhance GABA effects.
9. The method of claim 8 , wherein the standard anti-epileptic drug that modifies low-threshold or transient neuronal calcium currents is ethosuximide or the standard anti-epileptic drug that reduces high-frequency neuronal firing and sodium-dependent action potentials and may additionally enhance GABA effects is valproate.