Alpha 1-antitrypsin compositions and methods of making and using same
View Patent ↗The present invention relates to compositions comprising alpha 1-antitrypsin linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of alpha 1-antitrypsin-related diseases, disorders, and conditions.
1. An isolated fusion protein comprising a recombinant alpha 1-antitrypsin and a first extended recombinant polypeptide (XTEN), wherein said fusion protein is selected from the group consisting of the fusion peptide comprising the amino acid sequence of SEQ ID NO: 699, the fusion peptide comprising the amino acid sequence of SEQ ID NO: 701, the fusion peptide comprising the amino acid sequence of SEQ ID NO: 703, and the fusion peptide comprising the amino acid sequence of SEQ ID NO: 705.
2. A pharmaceutical composition, comprising the isolated fusion protein of claim 1 and a pharmaceutically acceptable carrier.
3. The isolated fusion protein of claim 1 , comprising the amino acid sequence of SEQ ID NO: 699.
4. The isolated fusion protein of claim 1 , comprising the amino acid sequence of SEQ ID NO: 701.
5. The isolated fusion protein of claim 1 , comprising the amino acid sequence of SEQ ID NO: 703.
6. The isolated fusion protein of claim 1 , comprising the amino acid sequence of SEQ ID NO: 705.