CaSR agonists
By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.
1. A glutamic acid derivative of formula (I) or a pharmaceutically acceptable thereof:
wherein R 1 and R 3 -R 5 are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a hydroxyl group, a nitro group, —NH 2 , an optionally substituted alkyl group having 1 to 6 carbon atoms, and an optionally substituted alkoxy group having 1 to 6 carbon atoms;
R 2 is selected from the group consisting of a nitro group, a sulfonic acid group,
R 6 is a hydroxyl group;
R 7 is a hydrogen atom or an optionally substituted alkyl group having 1 to 6 carbon atoms; and
X is a methylene group or an oxygen atom.
2. A pharmaceutical composition comprising a glutamic acid derivative of formula (I) or a pharmaceutically acceptable salt thereof:
wherein R 1 and R 3 -R 5 are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a hydroxyl group, —NH 2 , an optionally substituted alkyl group having 1 to 6 carbon atoms, and an optionally substituted alkoxy group having 1 to 6 carbon atoms;
R 2 is selected from the group consisting of a sulfonic acid group,
R 6 and R 7 are each independently a hydrogen atom or an optionally substituted alkyl group having 1 to 6 carbon atoms; and
X is a methylene group or an oxygen atom,
and excluding a compound wherein X is a methylene group, R 2 is
3. A pharmaceutical composition comprising the glutamic acid derivative or pharmaceutically acceptable salt thereof according to claim 1 and a pharmaceutically acceptable carrier.
4. The glutamic acid derivative or pharmaceutically acceptable salt thereof of claim 1 , wherein X is methylene.
5. The glutamic acid derivative or pharmaceutically acceptable salt thereof of claim 2 , wherein X is methylene.