IP Library › Granted Patent US 8,258,315
Granted Patent B2
US 8,258,315 · App. 13/079,376 · Granted Sep 4, 2012

Process for forming amorphous atorvastatin

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Quick Facts
Patent No.
US 8,258,315
App. No.
13/079,376
Granted
Sep 4, 2012
Kind
B2
Abstract

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

Claims (5)

1. A process for forming amorphous atorvastatin comprising:

(a) dissolving atorvastatin in a water solvent containing an alkalizing agent selected from the group consisting of: an alkali metal salt; an alkali metal hydroxide; and alkaline earth metal salt; an alkaline earth metal hydroxide; an amino acid; and a volatile base; and

(b) lyophilizing the solution to afford said amorphous atorvastatin.

2. The process of claim 1 wherein volatile base is selected from the group consisting of: ammonium hydroxide; a tetraalkylammonium hydroxide; a secondary amine; a tertiary amine; an aryl amine; and ammonium bicarbonate.

3. The process of claim 1 wherein the alkali metal hydroxide is sodium hydroxide.

Assignments (2)
CHANGE OF NAME Recorded Oct 31, 2022
From: UPJOHN US 1 LLC
To: VIATRIS SPECIALTY LLC.
Reel/Frame 061808/0420 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2020
From: PFIZER INC.
To: UPJOHN US 1 LLC
Reel/Frame 054293/0154 →