Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device

1. A device for delivering a treatment medium to an eye, comprising:

a first body portion and a second body portion;

wherein the first body portion is configured and arranged to be removably secured within a natural opening comprising a single punctum of the eye; and

wherein the second body portion comprises a coating that is applied to an end segment of the first portion, which coating is configured or arranged so the treatment medium is controllably released therefrom to the eye;

and wherein the delivery device is configured and arranged such that when at least a part of the first body portion is removably inserted into the punctum, the device occludes or plugs the punctum.

2. The device of claim 1 , wherein the treatment medium comprises a prostaglandin.

3. The device of claim 2 , wherein the first body portion includes a plug type member, one end of which is configured and arranged so as to be removably secured within the punctum.

4. The device of claim 3 , wherein the first body portion includes an end which is configured and arranged so as to form a structure to which is applied the coating from which the treatment medium is controllably released.

5. The device of claim 4 , wherein the first body portion comprises a lumen or an open compartment located within the first body portion.

6. The device of claim 5 , wherein the treatment medium is delivered in a controllable manner over a predetermined time period directly to the eye.

7. The device of claim 1 , wherein the treatment medium is retained in proximity to the external surface of the eye and is prevented from leaving the treatment site via the blocked punctum.

8. The device of claim 1 , wherein the treatment medium is selected from the group consisting of thrombin inhibitors; antithrombogenic agents; thrombolytic agents; fibrinolytic agents; vasospasm inhibitors; calcium channel blockers; vasodilators; antihypertensive agents; antimicrobial agents; inhibitors of surface glycoprotein receptors; antiplatelet agents; antimitotics; microtubule inhibitors; anti-secretory agents; active inhibitors; remodeling inhibitors; antisense nucleotides; anti-metabolites; antiproliferatives; anticancer chemotherapeutic agents; anti-inflammatories; non-steroidal anti-inflammatories; antiallergenics; antiproliferative agents; decongestants; miotics and anticholinesterase; antineoplastics; immunological drugs; hormonal agents; immunosuppressive agents; growth hormone antagonists; growth factors; inhibitors of angiogenesis; dopamine agonists; radiotherapeutic agents; peptides; proteins; enzymes; extracellular matrix components; ACE inhibitors; free radical scavengers; chelators; antioxidants; anti-polymerases; photodynamic therapy agents; gene therapy agents; prostaglandins; antiprostaglandins; prostaglandin precursors and combinations thereof.

9. The device of claim 1 , wherein the first body portion comprises a first end that is configured to facilitate insertion of the first body portion into the punctum.

10. The device of claim 1 , wherein the first body portion comprises a second end that is configured to form a support for the second body portion.

11. The device of claim 1 , wherein the first body portion extends along a longitudinal axis.

12. A method for treating an eye, comprising:

providing a delivery device according to claim 1 ; and

inserting the first portion of the delivery device into a punctum of the eye such that the first portion is retained by a single lacrimal canaliculus of the eye and the second portion of the delivery device is adjacent to an external surface of the eye.