IP Library Granted Patent US 8,679,348
Granted Patent B2
US 8,679,348 · App. 13/083,915 · Granted Mar 25, 2014

Filtration system for preparation of fluids for medical applications

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Quick Facts
Patent No.
US 8,679,348
App. No.
13/083,915
Granted
Mar 25, 2014
Kind
B2
Abstract

Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment which provides multiple benefits and liabilities to overcome, as discussed herein. Mechanisms for preparing pure water for infusion or medicaments are described such as elimination of chlorine and colloidal aluminum. Also various control mechanisms to help avoid contamination are describe.

Claims (62)

1. A method of providing a treatment fluid, comprising:

providing a water purification plant with a replaceable component having first and second filter stages, each stage being sufficient to purify the water to the same target level of purity and thereby the stages being redundant;

providing a breakthrough water quality sensor between the first and second stages;

receiving a command to produce a batch of purified water;

determining whether the replaceable component is expired responsive to a data carrier affixed to the replaceable component;

responsively to a result of the determining, pumping unpurified water through the first stage and then through the second stage into a batch container if the replaceable component is determined to be unexpired and preventing pumping if the replaceable component is expired;

conditioned on detecting a breakthrough of contamination responsively to the water quality sensor, continuing the pumping to flow a predetermined amount of water into the batch container while the second stage provides the target level of purity and thereafter preventing the pump from flowing water through the replaceable component until the replaceable component is replaced; and

after replacing the replaceable component, repeating the determining and pumping using a new replaceable component,

wherein the first filter stage has a substantially larger capacity than the second stage.

2. The method of claim 1 , wherein the water quality sensor is a conductivity cell.

3. The method of claim 1 , wherein the first filter stage includes a separate deionization filter with separate cation and anion beds.

4. The method of claim 1 , wherein the first filter stage includes a separate deionization filter with separate cation and anion beds, and the second filter stage includes a mixed cation-anion bed.

5. A method of providing a treatment fluid, comprising:

providing a water purification system having a replaceable component, the replaceable component including first and second redundant filter stages, each filter stage being sufficient alone to purify water passing therethrough to a same target level of purity, a water quality sensor being arranged between the first and second filter stages;

responsive to a command to produce a batch of purified water, determining whether the replaceable component is expired based on information contained in a data carrier affixed to the replaceable component;

when it is determined that the replaceable component is expired, preventing pumping of water through the replaceable component;

when it is determined that the replaceable component is not expired, pumping water through the replaceable component, including the at least a first and second redundant filter stages thereof, into a batch container; and

when, during said pumping, a breakthrough of contamination is detected by said water quality sensor, continuing the pumping to flow a predetermined amount of water into the batch container, the target level of purity of the water during the continuing the pumping being provided by the second redundant filter stage alone; and

after said continuing the pumping, preventing subsequent pumping of water through the replaceable component,

wherein the first filter stage has a substantially larger capacity than the second stage.

6. The method of claim 5 , wherein said preventing subsequent pumping includes updating the data carrier of the replaceable component to indicate that the replaceable component is expired.

7. The method of claim 5 , further comprising:

replacing the replaceable component with a new replaceable component; and

repeating the determining and the pumping with the new replaceable component.

8. The method of claim 5 , wherein the pumping through the replaceable component is such that the water flows through the first filter stage and then the second filter stage.

9. The method of claim 5 , wherein the water quality sensor is a conductivity cell.

10. The method of claim 5 , wherein the first filter stage includes a separate deionization filter with separate cation and anion beds, and the second filter stage includes a mixed cation-anion bed.

11. The method of claim 1 , further comprising performing a medical treatment within a predefined period of time after producing the batch of purified water.

12. The method of claim 5 , further comprising performing a medical treatment within a predefined period of time after producing the batch of purified water.

13. A method of providing a treatment fluid, comprising:

providing a water purification plant with a replaceable component having first and second filter stages, each stage being sufficient to purify the water to the same target level of purity and thereby the stages being redundant;

providing a breakthrough water quality sensor between the first and second stages;

receiving a command to produce a batch of purified water;

determining whether the replaceable component is expired responsive to a data carrier affixed to the replaceable component;

responsively to a result of the determining, pumping unpurified water through the first stage and then through the second stage into a batch container if the replaceable component is determined to be unexpired and preventing pumping if the replaceable component is expired;

conditioned on detecting a breakthrough of contamination responsively to the water quality sensor, continuing the pumping to flow a predetermined amount of water into the batch container while the second stage provides the target level of purity and thereafter preventing the pump from flowing water through the replaceable component until the replaceable component is replaced; and

after replacing the replaceable component, repeating the determining and pumping using a new replaceable component,

wherein the replaceable component is configured as a single unit such that the first and second stages are replaced simultaneously and the method further includes replacing the replaceable component responsively to, and upon, the detection of the breakthrough of contamination and responsively to, and upon, the completion of the flowing of the predetermined amount of water.

14. A method of providing a treatment fluid, comprising:

providing a water purification system having a replaceable component, the replaceable component including first and second redundant filter stages, each filter stage being sufficient alone to purify water passing therethrough to a same target level of purity, a water quality sensor being arranged between the first and second filter stages;

responsive to a command to produce a batch of purified water, determining whether the replaceable component is expired based on information contained in a data carrier affixed to the replaceable component;

when it is determined that the replaceable component is expired, preventing pumping of water through the replaceable component;

when it is determined that the replaceable component is not expired, pumping water through the replaceable component, including the at least a first and second redundant filter stages thereof, into a batch container; and

when, during said pumping, a breakthrough of contamination is detected by said water quality sensor, continuing the pumping to flow a predetermined amount of water into the batch container, the target level of purity of the water during the continuing the pumping being provided by the second redundant filter stage alone; and

after said continuing the pumping, preventing subsequent pumping of water through the replaceable component,

wherein the replaceable component is configured as a single unit such that the first and second stages are replaced simultaneously and the method further includes replacing the replaceable component responsively to, and upon, the detection of the breakthrough of contamination and responsively to, and upon, the completion of the flowing of the predetermined amount of water.

15. The method of claim 1 , wherein the replaceable component is configured as a single unit such that the first and second stages are replaced simultaneously and the method further includes replacing the replaceable component responsively to, and upon, the detection of the breakthrough of contamination and responsively to, and upon, the completion of the flowing of the predetermined amount of water.

16. The method of claim 5 , wherein the replaceable component is configured as a single unit such that the first and second stages are replaced simultaneously and the method further includes replacing the replaceable component responsively to, and upon, the detection of the breakthrough of contamination and responsively to, and upon, the completion of the flowing of the predetermined amount of water.

17. The method of claim 15 , further comprising performing a medical treatment within a predefined period of time after producing the batch of purified water.

18. The method of claim 16 , further comprising performing a medical treatment within a predefined period of time after producing the batch of purified water.

19. The method of claim 13 , wherein the water quality sensor is a conductivity cell.

20. The method of claim 13 , wherein the first filter stage includes a separate deionization filter with separate cation and anion beds.

21. The method of claim 13 , wherein the first filter stage includes a separate deionization filter with separate cation and anion beds, and the second filter stage includes a mixed cation-anion bed.

22. The method of claim 13 , further comprising performing a medical treatment within a predefined period of time after producing the batch of purified water.

23. The method of claim 14 , wherein said preventing subsequent pumping includes updating the data carrier of the replaceable component to indicate that the replaceable component is expired.

24. The method of claim 14 , further comprising:

replacing the replaceable component with a new replaceable component; and

repeating the determining and the pumping with the new replaceable component.

25. The method of claim 14 , wherein the pumping through the replaceable component is such that the water flows through the first filter stage and then the second filter stage.

26. The method of claim 14 , wherein the water quality sensor is a conductivity cell.

27. The method of claim 14 , wherein the first filter stage includes a separate deionization filter with separate cation and anion beds, and the second filter stage includes a mixed cation-anion bed.

28. The method of claim 14 , further comprising performing a medical treatment within a predefined period of time after producing the batch of purified water.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Feb 21, 2019
From: CAPITAL ONE, NATIONAL ASSOCIATION (AS SUCCESSOR BY MERGER TO HEALTHCARE FINANCIAL SOLUTIONS, LLC)
To: NXSTAGE MEDICAL, INC.
Reel/Frame 048407/0865 →
ASSIGNMENT OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Nov 16, 2015
From: GENERAL ELECTRIC CAPITAL CORPORATION, AS RETIRING AGENT
To: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS SUCCESSOR AGENT
Reel/Frame 037112/0376 →
SECURITY INTEREST Recorded Jun 10, 2014
From: NXSTAGE MEDICAL, INC.
To: GENERAL ELECTRIC CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 033123/0836 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2012
From: BURBANK, JEFFREY H.; GREEN, BRIAN C.; TREU, DENNIS M.; MCDOWELL, CHRISTOPHER S.; GOETZ, FRIEDERICHS
To: NXSTAGE MEDICAL, INC.
Reel/Frame 027740/0432 →