Processes for producing monoammonium adipate and conversion of monoammonium adipate to adipic acid
View Patent ↗A process for making MAA from a clarified DAA-containing fermentation broth includes (a) distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAA, at least some DAA, and at least about 20 wt. % water; (b) cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a DAA-containing liquid portion in contact with a MAA-containing solid portion that is substantially free of DAA; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
1. A process for obtaining monoammonium adipate (MAA) from an aqueous clarified diammonium adipate (DAA)-containing fermentation broth comprising:
(a) providing an aqueous clarified diammonium adipate (DAA)-containing fermentation broth;
(b) distilling the broth to form an overhead that comprises water and ammonia, and a liquid bottoms that comprises MAA, at least some DAA, and at least 20 wt. % water;
(c) cooling, evaporating or evaporative cooling the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAA-containing liquid portion and a MAA-containing solid portion that is substantially free of DAA;
(d) separating the solid portion from the liquid portion; and
(e) recovering the solid portion.
2. The process of claim 1 , wherein the solid portion is substantially free of adipamic acid, adipamide and adipimide.
3. The process of claim 1 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
4. A process for obtaining adipic acid (AA) from a clarified DAA-containing fermentation broth, comprising:
(a) providing a clarified DAA-containing fermentation broth;
(b) distilling the broth to form a first overhead that comprises water and ammonia, and a first liquid bottoms that comprises MAA, at least some DAA, and at least 20 wt. % water;
(c) cooling, evaporating or evaporative cooling the first bottoms, and optionally adding an antisolvent to the first bottoms, to attain a temperature and composition sufficient to cause the first bottoms to separate into a DAA-containing first liquid portion and a MAA-containing first solid portion that is substantially free of DAA;
(d) separating the first solid portion from the first liquid portion;
(e) recovering the first solid portion;
(f) dissolving the first solid portion in water to produce an aqueous MAA solution;
(g) distilling the aqueous MAA solution at a temperature and pressure sufficient to form a second overhead that comprises water and ammonia, and a second bottoms that comprises a major portion of AA, a minor portion of MAA, and water;
(h) cooling, evaporating or evaporative cooling the second bottoms to cause the second bottoms to separate into a second liquid portion and a second solid portion that consists essentially of AA and is substantially free of MAA;
(i) separating the second solid portion from the second liquid portion; and
(j) recovering the second solid portion.
5. The process of claim 4 , wherein the first and second solid portions are substantially free of adipamic acid, adipamide and adipamide.
6. The process of claim 4 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
7. A process for obtaining MAA from an aqueous clarified MAA-containing fermentation broth comprising:
(a) providing an aqueous clarified MAA-containing fermentation broth;
(b) optionally adding an additional amount of at least one of MAA, DAA, AA, NH 3 , and NH 4 + , to the broth depending on pH of the broth;
(c) distilling the broth to form an overhead that comprises water and optionally ammonia and a liquid bottoms that comprises MAA, at least some DAA, and at least 20 wt. % water;
(d) cooling, evaporating or evaporative cooling the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAA-containing liquid portion and a MAA-containing solid portion that is substantially free of DAA;
(e) separating the solid portion from the liquid portion; and
(f) recovering the solid portion.
8. The process of claim 7 , wherein the solid portion are substantially free of adipamic acid, adipamide and adipimide.
9. The process of claim 7 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
10. A process for obtaining AA from a clarified MAA-containing fermentation broth comprising:
(a) providing a clarified MAA-containing fermentation broth;
(b) optionally adding an additional amount of at least one of MAA, DAA, AA, NH 3 , and NH 4 + , to the broth depending on pH of the broth;
(c) distilling the broth to form an first overhead that comprises water and, optionally, ammonia and a first liquid bottoms that comprises MAA, at least some DAA, and at least 20 wt. % water;
(d) cooling, evaporating or evaporative cooling the first bottoms, and optionally adding an antisolvent to the first bottoms, to attain a temperature and composition sufficient to cause the first bottoms to separate into a DAA-containing first liquid portion and a MAA-containing first solid portion that is substantially free of DAA;
(e) separating the first solid portion from the first liquid portion;
(f) dissolving the first solid portion in water to produce an aqueous MAA solution;
(g) distilling the aqueous MAA solution at a temperature and pressure sufficient to form a second overhead that comprises water and ammonia, and a second bottoms that comprises a major portion of AA, a minor portion of MAA, and water;
(h) cooling, evaporating or evaporative cooling the second bottoms to cause the second bottoms to separate into a second liquid portion and a second solid portion that consists essentially of AA and is substantially free of MAA;
(i) separating the second solid portion from the second liquid portion; and
(j) recovering the second solid portion.
11. The process of claim 10 , wherein the first and second solid portions are substantially free of adipamic acid, adipamide, and adipimide.
12. The process of claim 10 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
13. A process for obtaining mono-X adipate (MXA) from a clarified DAA-containing fermentation broth comprising:
(a) providing a clarified DAA-containing fermentation broth;
(b) distilling the broth to form an overhead that comprises water and ammonia, and a liquid bottoms that comprises MXA, where X is at least one of NH 4 + , Na + and K + , at least some di-Y adipate (DYA), where DYA includes DAA and at least one of disodium adipate (DNaA) and dipotassium adipate (DKA), and at least 20 wt. % water;
(c) cooling, evaporating or evaporative cooling the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DYA-containing liquid portion and a MXA-containing solid portion that is substantially free of DYA;
(d) separating the solid portion from the liquid portion; and
(e) recovering the solid portion.
14. The process of claim 13 , wherein the first and second solid portions are substantially free of adipamic acid, adipamide, and adipimide.
15. The process of claim 13 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
16. A process for obtaining MXA from a clarified MXA-containing broth, where X is at least one of NR 4 + , Na + and K + comprising:
(a) providing a clarified MXA-containing broth;
(b) optionally adding an additional amount of at least one of AA, NH 3 , NH 4 + , Na + , and K + to the broth to maintain the pH of the broth below 6 ;
(c) distilling the broth to form an overhead that includes water and optionally ammonia, and a liquid bottoms that includes MXA, at least some DYA, where DYA includes at least one of DAA, DNaA and DKA, and at least 20 wt. % water;
(d) cooling, evaporating or evaporative cooling the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DYA-containing liquid portion and a MXA-containing solid portion that is substantially free of DYA;
(e) separating the solid portion from the liquid portion; and
(f) recovering the solid portion.
17. The process of claim 16 , wherein the first and second solid portions are substantially free of adipamic acid, adipamide, and adipimide.
18. The process of claim 16 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
19. A process for obtaining magnesium adipate from a clarified DAA-containing fermentation broth comprising:
(a) providing a clarified DAA-containing fermentation broth;
(b) distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MgA, at least some DAS and MgA and at least 20 wt. % water;
(c) cooling, evaporating or evaporative cooling the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a DAA and MgA -containing liquid portion and an MgA-containing solid portion that is substantially free of DAA;
(d) separating the solid portion from the liquid portion; and
(e) recovering the solid portion.
20. The process of claim 19 , wherein the first and second solid portions are substantially free of adipamic acid, adipamide, and adipimide.
21. The process of claim 19 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.
22. A process for obtaining MgA from a clarified MAA-containing fermentation broth comprising:
(a) providing a clarified MAA-containing fermentation broth;
(b) optionally adding an additional amount of at least one of AA, NH 3 , NH 4 + and Mg +2 to the broth depending on pH of the broth;
(c) distilling the broth to form an overhead that comprises water and optionally ammonia and a liquid bottoms that comprises MgA, at least some MAA, and at least 20 wt. % water;
(d) cooling, evaporating or evaporative cooling the bottoms, and optionally adding an antisolvent to the bottoms, to attain a temperature and composition sufficient to cause the bottoms to separate into a MAA-containing liquid portion and a MgA-containing solid portion that is substantially free of MAA;
(e) separating the solid portion from the liquid portion; and
(f) recovering the solid portion.
23. The process of claim 22 , wherein the first and second solid portions are substantially free of adipamic acid, adipamide, and adipimide.
24. The process of claim 22 , wherein the antisolvent is selected from the group consisting of an alcohol, a ketone, and an ether.