Glue composition for lung volume reduction
View Patent ↗The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
1. A method of reducing lung volume in a lung of a subject in need thereof, comprising:
administering an effective amount of a glue composition to a localized region of damaged lung tissue of the subject, wherein the glue composition comprises a polyvinylalcohol polymer and a cross-linker, such that the polymer and cross-linker form a hydrogel in the lung, thereby reducing lung volume in the lung of the subject.
2. The method of claim 1 , wherein said lung tissue comprises epithelial lining fluid.
3. The method of claim 1 , wherein said administering delivers said glue composition to a deep lung region.
4. The method of claim 1 , wherein said method is performed with prior identification of said damaged lung tissue.
5. The method of claim 1 , wherein said glue composition further comprises a sclerosing agent that damages epithelial cells within lung tissue.
6. The method of claim 5 , wherein said sclerosing agent is at least one compound selected from doxycycline, bleomycin, minocycline, doxorubicin, cisplatin+cytarabine, mitoxantrone, Corynebacterium Parvum , streptokinase, and urokinase.
7. The method of claim 1 , wherein said glue composition is less than 10 microns.
8. The method of claim 1 , wherein said glue composition is less than 5 microns.
9. The method of claim 1 , wherein said glue composition is less than 1 micron.
10. The method of claim 1 , wherein said administering is carried out via inhalation.
11. The method of claim 10 , wherein said inhalation is carried out via the mouth.
12. The method of claim 1 , wherein said administering is carried out via trans-thoracic administration.
13. The method of claim 1 , wherein said administering is carried out by placing a bronchoscope in a bronchi of a deep lung region.
14. The method of claim 13 , further comprising placing a catheter through said bronchoscope to reach a subsegmental bronchi.
15. The method of claim 14 , wherein said catheter comprises an expandable balloon-like structure.
16. The method of claim 1 , wherein said subject is suffering from a pulmonary condition.
17. The method of claim 16 , wherein said pulmonary condition is emphysema or chronic obstructive pulmonary disease.
18. A method of reducing lung volume in a lung of a subject in need thereof comprising:
providing a glue composition comprising a cross-linkable moiety and a polyvinylalcohol;
administering said glue composition to a localized region of the lung tissue of the subject; and
cross-linking said cross-linkable moiety and said polyvinylalcohol to form a hydrogel, thereby reducing lung volume.
19. The method of claim 18 , wherein said glue composition further comprises a sclerosing agent that damages epithelial cells within lung tissue.
20. The method of claim 19 , wherein said sclerosing agent is at least one compound selected from doxycycline, bleomycin, minocycline, doxorubicin, cisplatin+cytarabine, mitoxantrone, Corynebacterium Parvum , streptokinase, and urokinase.