Synthetic arginine substituted peptides and their use
View Patent ↗The present invention relates to new arginine substituted peptides designed based on the sequence of human lactoferrin and to use thereof, in particular for treatment and/or prevention of infections, inflammations, tumors, pain, wounds and/or scars.
1. An isolated peptide according to formula (I′)
wherein amino acid X1 is Gln or Lys, and amino acid X2 is Asn or Ala;
the bond α is an amide bond between the 6-amino group in Lys and the carboxyl group in Ser;
n is an integer from 3 to 6;
R1 is either no amino acid or the peptide sequence Ala-Thr-Lys-CysM;
R2 is either no amino acid or the peptide sequence Pro-Pro-Val-Ser-CysM-Ile-Lys-Arg;
CysM is acetamidomethyl-cysteine;
wherein a free COOH at a carboxy terminal end optionally has been transformed into CONH 2 ;
wherein a free NH 2 group at an amino terminal end optionally has been transformed into the amide CH 3 CONH; and
wherein the peptide is selected from the group of peptides consisting of the peptides:
2. An isolated peptide according to claim 1 , which is the peptide
3. A pharmaceutical composition comprising a peptide according to claim 1 .
4. A pharmaceutical composition according to claim 3 , formulated for systemic administration, parenteral administration, local administration or topical administration.