IP Library › Granted Patent US 8,153,140
Granted Patent B2
US 8,153,140 · App. 13/089,924 · Granted Apr 10, 2012

Chimeric MSP-based malaria vaccine

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Quick Facts
Patent No.
US 8,153,140
App. No.
13/089,924
Granted
Apr 10, 2012
Kind
B2
Abstract

The invention provides an immunogenic composition comprising MSP-8 linked to an antigen. Methods of using the composition to induce an immune response in an animal are also provided.

Claims (7)

1. A method of inducing an immune response in an animal, the method comprising

administering to the animal an effective amount of a composition comprising a chimeric protein, wherein said chimeric protein comprises Plasmodium merozoite surface protein-8 (MSP-8) linked to MSP-1 19 .

2. The composition of claim 1 , wherein said MSP-1 19 is covalently linked to said MSP-8.

3. The composition of claim 1 , wherein said MSP-8 and said MSP-1 19 are P. falciparum or P. vivax sequences.

4. The composition of claim 1 , further comprising a pharmaceutically acceptable carrier.

5. The composition of claim 1 , further comprising an adjuvant.

6. The composition of claim 2 , wherein MSP-1 19 is covalently linked to MSP-8 to form a fusion protein comprising the sequence of SEQ ID No. 23.

Assignments (2)
MERGER Recorded Jan 14, 2015
From: PHILADELPHIA HEALTH & EDUCATION CORPORATION
To: DREXEL UNIVERSITY
Reel/Frame 034764/0236 →
CONFIRMATORY LICENSE Recorded Oct 19, 2012
From: DREXEL UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029156/0357 →