Parathyroid hormone receptor activation and stem and progenitor cell expansion
The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells.
1. A method for treating a subject having or at risk of having leukemia, the method comprising:
administering to the subject a PTH, a PTH analogue, or a PTH/PTHrP receptor agonist in an amount effective to increase the amount of normal hematopoietic stem and progenitor cells; and
decreasing the amount of leukemic or pre-leukemic cells, thereby treating a subject having or at risk of having leukemia.
2. The method of claim 1 , wherein the leukemia is chronic.
3. The method of claim 2 , wherein the chronic leukemia is chronic myeloid, chronic myelogenous or chronic granulocytic leukemia.
4. The method of claim 1 , wherein the leukemia is acute.
5. The method of claim 4 , wherein the acute leukemia is acute lymphoblastic leukemia or acute nonlymphoblastic leukemia.