Implantable medical device having enhanced endothelial migration features and methods of making the same
View Patent ↗An implantable medical device having enhanced endothelial migration features, generally comprises: a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, and the trailing edge including a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.
1. An implantable medical device having enhanced endothelial migration features, comprising:
a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a generally curvilinear cross-section, and the trailing edge including a generally curvilinear cross-section, wherein the leading edge connects to a first edge and the trailing edge connects to a third edge, and the height of the leading edge is above the height of the connecting points of the leading edge and the first edge and above the height of the connecting points of the trailing edge and the third edge; whereby blood flow over the leading edge generates a continuous and increased shear stress at the leading edge and the third surface region without an eddy region in the leading edge:
wherein the leading edge joins the first edge at an angle As, wherein the angle As is less than 90 degrees.
2. The implantable medical device of claim 1 , wherein the shear stress generated at the leading edge is between about 5 and 25 dynes/cm 2 and the migration rate of cells is increased to a rate of 25 μm/hr across the leading edge.
3. The implantable medical device of claim 1 , wherein the leading edge includes a radius of curvature Rs, wherein Rs is between about 1 nm to about 75 mm.
4. The implantable medical device of claim 3 , wherein the leading edge is concave into the structural member.
5. The implantable medical device of claim 4 , wherein the leading edge joins the third surface region at an angle At, wherein the angle At is greater than 90 degrees.
6. The implantable medical device of claim 5 , wherein the length of the third surface region is less than the length of the leading edge.
7. The implantable medical device of claim 6 , wherein the first edge joins a second edge and the second edge joins the third edge, whereby the third edge joins the trailing edge to form a substantially hexagonal cross-section configuration of the structural member.
8. The implantable medical device of claim 7 , wherein the trailing edge includes a radius of curvature Rr, wherein Rr is between about 1 nm to about 75 mm.
9. The implantable medical device of claim 8 , wherein the trailing edge joins the third edge at an angle Ar, wherein the angle Ar is less than 90 degrees.
10. The implantable medical device of claim 9 , wherein the trailing edge joins the third surface region at an angle Aq, wherein the angle Aq is greater than 90 degrees.
11. The implantable medical device of claim 10 , wherein the length of the third surface region is less than the length of the trailing edge.
12. The implantable medical device of claim 11 , wherein the leading edge and the trailing edge each include a plurality of geometric physiologically functional features including a focal adhesion point for affinity binding of endothelial cells.
13. The implantable medical device of claim 11 , wherein the leading edge and the trailing edge each include a plurality of grooves disposed thereon.
14. A method of forming an implantable medical device having enhanced endothelial migration features, comprising:
forming a structural member including a leading edge and a trailing edge interconnected by a fourth face including a third surface region,
forming the leading edge to include a generally curvilinear cross-section, wherein the leading edge connects to a first edge and the trailing edge connects to a third edge, and the height of the leading edge is above the height of the connecting points of the leading edge and the first edge and above the height of the connecting points of the trailing edge and the third edge;
joining the leading edge to the first edge at an angle As, wherein the angle As is less than 90 degrees;
and forming the trailing edge to include a generally curvilinear cross-section, whereby blood flow over the leading edge generates a continuous and increased shear stress at the leading edge and the third surface region without an eddy region in the leading edge.
15. The method of claim 14 , further comprising forming the leading edge to include a radius of curvature Rs, wherein Rs is between about 1 nm to about 75 mm.
16. The method of claim 15 , further comprising forming the leading edge to be concave into the structural member.
17. The method of claim 16 , further comprising joining the leading edge to the third surface region at an angle At, wherein the angle At is greater than 90 degrees.
18. The method of claim 17 , further comprising joining the first edge to a second edge and joining the second edge to the third edge, whereby the third edge joins the trailing edge to form a substantially hexagonal cross-section configuration of the structural member.
19. The method of claim 18 , wherein the trailing edge includes a radius of curvature Rr, wherein Rr is between about 1 nm to about 75 mm.
20. The method of claim 19 , further comprising joining the trailing edge to the third edge at an angle Ar, wherein the angle Ar is less than 90 degrees.